DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and igcm-1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_508166.1	Gene:	igcm-1 / 180433	WormBaseID:	WBGene00018215	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	1224	Identity:	262/1224 - (21%)
Similarity:	429/1224 - (35%)	Gaps:	353/1224 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 IEIKGYSHNSKVEVRE-----------NQDLQLKCIVANAKP------AAQIVWYR-GNVEYKPE 223
            :::...:.:|.|.::|           |:.:.:.|:|   ||      ..:|.|.| .|.:.:..
Worm    15 VQLTNSADSSDVFLKEPSSEPYFLQEGNEGIVIPCVV---KPEYFDRQKYEINWARYNNGQLRMI 76

  Fly   224 KREDTVEESTAKRF-------TTTSSLKLKP---------------GPDDDYTEYTCQARHKALS 266
            .:.|.:......||       |...||::..               |.||...:|:
Worm    77 TKNDKLLAKKHSRFILENDSATGNYSLRITEVEKNSVEGTYHCNVIGTDDSDVQYS--------- 132

  Fly   267 PDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMA- 330
                  |...:.||.|||.|.| ..:..|::..|..:...|.|.||:|.....|......|..:
Worm   133 ------ALATVVVLVPPGDPII-STTPSESVIEGDFMTAKCVSVGGSPQPTFTWTLPNDTIASSA 190

  Fly   331 -YRTSGR--LSENIYTFTAEAGDNKARFRCEASN---VMSQNPLKAEVELSVLFAPTHVTVMGPT 389
             :.|..|  .:|::..|...:.|:....:|:.:|   :..:.......:|:||:.|  |..:.||
Worm   191 IFTTQFRDGATESLLHFRVTSSDDGKSVQCDVTNRAMLGGETKQVKSSQLNVLYKP--VVFVTPT 253

  Fly   390 E------ARVGDIVPLTCTTAPSNPPA---EIKWMVGGRQ-------VRNATSKTIVSPEGGWTT 438
            |      ...|::|.|||.:| |||||   |.|.:..|.:       :|..:|   :|.:....:
Worm   254 ENLTHLSVEEGELVNLTCNSA-SNPPAHSYEWKHIASGERYQGKIWPIRVDSS---MSGDFECRS 314

  Fly   439 TSNI---TAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQ 500
            |:.:   |||::      :|:.|...:.:.|::......::
Worm   315 TNELGEGTAVLK------MVVQHIPRINVPESISPNEMEDI------------------------ 349

  Fly   501 KLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASN------- 558
            .:||..|....:..:.|         |.....|...:.:||.:........|.|.|:|
Worm   350 DILCEVSAVPEVIDIKW---------VGPNGFKQNGSRLTITSISKAQSGNYTCMATNFLTVYGH 405

  Fly   559 SATEIPLFQSTTL-SVHFAPETVKIRIEPEELRPGMEATIICDS-SSSNPPAKLSWWKDGIPIEG 621
            |.::..:...||: .|...|...:|....:.:..|....::|.: .:.||.|..:|   ..|..|
Worm   406 SGSQQRMGTGTTIVDVKRKPGQAQIVSARQNVDVGETIKLMCQAEDAGNPSASYTW---ASPSSG 467

  Fly   622 INNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSS 686
                ...||.|.|..:.|.| |.....|| ||:|::.|: |.......|.:.|:.:.:...|.::
Worm   468 ----GIFGLEGHTEKSFEVR-NAQLSDNG-VYSCKAYND-LGEGKIGTVMITVIEKARISSPLAT 525

  Fly   687 TAVGVEGESLQV-SLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSC 750
            ..:...||..:: ..:.:..|:|| .||.|||..:.|                       .||:.
Worm   526 ERIFTSGEQGKILECEAQGYPSPV-IKWLKDGRPVKQ-----------------------SIYAS 566

  Fly   751 SASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTV 815
            ||                                        |.|.|.|.|:..       ..||
Worm   567 SA----------------------------------------TSESKCLPEDFC-------TQTV 584

  Fly   816 KTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRD----ILLIVKFAPEI--AKTPTLL 874
            .::.|.|.        ..|..|.|||.|||||..|. |::|    .::.|...|..  .|.|...
Worm   585 ASTLTLAG--------PLKWSDKGNFTCVADNGSDK-TDKDSSSWTIVRVLHKPVFLNRKFPEKS 640

  Fly   875 RAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVE--ERKIDSLTYESTLIVDKVA 937
            .||:..|.:..:.|:....|:|:|.|.....::..|..:.:...  ..|.|.  ||..|.::.|.
Worm   641 LAAADIGSQAIIRCKVSARPEPEFHWMFRDSEISENERHSFHTVGITGKPDE--YEQLLQIESVQ 703

  Fly   938 PADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVR 1002
            .:|||.|.|.|.|..|.....:.|..||.|..||.|..|:.|.::|.|.|.|.||||...:|.:.
Worm   704 ESDYGEYVCRATNGNGGDHVVIELRKTSPPALPLDLQKLSATSNSVLLGWVPQFDGGADQTYVLE 768

  Fly  1003 YRMADR-------------------EQYKYIDG-LPNSHKLTIGGLRMNTLYLFSVMSWNELGQS 1047
            .|..|.                   :|.:.||| |.:.:.....||...:.|...:.:.:|.|:|
Worm   769 TRKIDPFTGEIDGNAPVSKLNINAVQQDQEIDGTLVSKNIFNFTGLTPLSTYNLRIQAVSEKGES 833

  Fly  1048 SYLPDLARAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVV---------VLL 1103
            .:.|.|. |.|::....::..|                .|.::|......|.|         .||
Worm   834 EFTPVLI-ASTEDVVEDANMMS----------------PSRLVLDSSEQKINVEPKLPSDACTLL 881

  Fly  1104 NVFVIG-----CCLHKRN---------EKRLK-----RGLELMPAELTEDSSN---------TPN 1140
            .||:.|     .|....|         |.|.:     .||:..|...|..|.:         .|.
Worm   882 YVFLDGIWRTSTCHTSSNPIGNIIPGREYRARFCTTANGLKCSPVSKTISSGSGSVWKTNVFFPF 946

  Fly  1141 LVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATI-----------EMYAPSSY 1194
            |..|.|.||...|.||                ..:|.:.| ||:.:           |:..|:.|
Worm   947 LFFIFIGLAICVFFLV----------------CCKTRSNP-KTSKLSPIILTSLPGDELKRPADY 994

  Fly  1195 ND------TVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVEGSDM 1242
            .:      .:|....:.:|:....     |::|..::.....:...||.|.:::
Worm   995 EEPKHATFAITENETNHLSQHDAK-----STKPPGLNMEYDVSTDCYLQENTEV 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	23/132 (17%)
		Ig	197..279	CDD:299845	19/110 (17%)
		IG_like	296..376	CDD:214653	16/86 (19%)
		Ig	300..361	CDD:299845	14/64 (22%)
		Ig	380..454	CDD:299845	26/92 (28%)
		IG_like	490..573	CDD:214653	15/90 (17%)
		Ig	501..560	CDD:299845	12/65 (18%)
		Ig	584..666	CDD:299845	22/82 (27%)
		IG_like	585..666	CDD:214653	22/81 (27%)
		I-set	678..767	CDD:254352	16/89 (18%)
		IGc2	692..757	CDD:197706	15/65 (23%)
		Ig	788..849	CDD:143165	19/60 (32%)
		Ig	885..960	CDD:143165	20/76 (26%)
		FN3	967..1051	CDD:238020	28/103 (27%)
igcm-1	NP_508166.1	Ig	45..119	CDD:299845	14/76 (18%)
		Ig	146..226	CDD:299845	18/80 (23%)
		Ig_3	245..316	CDD:290638	22/76 (29%)
		IG_like	258..329	CDD:214653	21/80 (26%)
		IG_like	338..398	CDD:214653	12/92 (13%)
		IGc2	347..398	CDD:197706	11/83 (13%)
		Ig_2	429..513	CDD:290606	24/93 (26%)
		IG_like	437..513	CDD:214653	23/85 (27%)
		Ig	537..615	CDD:143165	34/157 (22%)
		IG_like	644..728	CDD:214653	21/85 (25%)
		IGc2	646..719	CDD:197706	20/74 (27%)
		FN3	733..843	CDD:238020	31/110 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910