DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and Il1rap

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001152790.1	Gene:	Il1rap / 16180	MGIID:	104975	Length:	685	Species:	Mus musculus

Alignment Length:	688	Identity:	133/688 - (19%)
Similarity:	218/688 - (31%)	Gaps:	223/688 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 LTWYKNDKRINSVIR--AADKSVSAEITILANV---SDNQAQYRCEASNSATEIPLFQSTTLSVH 574
            |.||........:::  |:::.....:..:..:   .|..|:.:|         |||:      |
Mouse     3 LLWYLMSLSFYGILQSHASERCDDWGLDTMRQIQVFEDEPARIKC---------PLFE------H 52

  Fly   575 FAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWW---KDGIPIEGIN--------NTSKP 628
            |.....                    |::.:....|.|:   :|....|.||        :..|.
Mouse    53 FLKYNY--------------------STAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKD 97

  Fly   629 GLWGGTVSTLEFRVNVTQEMNGQVYTCQSAN-----------EALQRSA--HEAVSLDV--LYRP 678
            .||        ||..:..:...  |||...|           |.:|:.:  :.|:...|  :|..
Mouse    98 VLW--------FRPTLLNDTGN--YTCMLRNTTYCSKVAFPLEVVQKDSCFNSAMRFPVHKMYIE 152

  Fly   679 KFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRD 743
            ..:  ...|...|:|     ...:...|:...||    |.|...| .|.:..:|.:|:|......
Mouse   153 HGI--HKITCPNVDG-----YFPSSVKPSVTWYK----GCTEIVD-FHNVLPEGMNLSFFIPLVS 205

  Fly   744 DAGIYSCSASNSQGGATLNITVVVEYGTTIK--------------SVSENIVV--NPGEDAMLSC 792
            :.|.|:|..:..:.|...::|..|    |:|              |.::.:|.  .|||:.::.|
Mouse   206 NNGNYTCVVTYPENGRLFHLTRTV----TVKVVGSPKDALPPQIYSPNDRVVYEKEPGEELVIPC 266

  Fly   793 TVEGKPLTEEH--VKW-------ERVGYDMTVKTSTTFAN-----GTSYLHIKDAKREDV-GNFR 842
            .|....:.:.|  |.|       :.|..|:|:..|.::::     .|..|.||....||: .|:.
Mouse   267 KVYFSFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSIKKVTPEDLRRNYV 331

  Fly   843 CVADNRVDN------------PTNRDILLIVKFAPEIAKTPTLL--------------RAASGTG 881
            |.|.|....            |....:.|...|...:.....|:              ||..||.
Mouse   332 CHARNTKGEAEQAAKVKQKVIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTD 396

  Fly   882 ERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYEC 946
            |.                 ..|.|:..|..:|...|||.:...||....|      ..::|...|
Mouse   397 ET-----------------ILDGKEYDIYVSYARNVEEEEFVLLTLRGVL------ENEFGYKLC 438

  Fly   947 V-ARNEL--GEAVETV--------RLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYR 1000
            : .|:.|  |..||.|        |:.:...||        .||..::::.   .|..|:.....
Mouse   439 IFDRDSLPGGNTVEAVFDFIQRSRRMIVVLSPD--------YVTEKSISML---EFKLGVMCQNS 492

  Fly  1001 -------VRYR---------MADREQYKYID--GLPNSH------KLTIGGLRMNTLYLFSVMSW 1041
                   |.||         |..:|...::.  |..:.|      |.....|.:.:|...|  .|
Mouse   493 IATKLIVVEYRPLEQPHPGIMQLKESVSFVSWKGEKSKHSGSKFWKALRLALPLRSLSASS--GW 555

  Fly  1042 NELGQSS---YLPDLARAETKEAPPPSHPASSLGGGPP 1076
            ||...|.   .|..:.|....:.||....:..:.|..|
Mouse   556 NESCSSQSDISLDHVQRRSRLKEPPELRSSERVSGAEP 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	10/62 (16%)
		Ig	501..560	CDD:299845	7/49 (14%)
		Ig	584..666	CDD:299845	18/103 (17%)
		IG_like	585..666	CDD:214653	18/102 (18%)
		I-set	678..767	CDD:254352	18/88 (20%)
		IGc2	692..757	CDD:197706	14/64 (22%)
		Ig	788..849	CDD:143165	19/75 (25%)
		Ig	885..960	CDD:143165	18/85 (21%)
		FN3	967..1051	CDD:238020	21/110 (19%)
Il1rap	NP_001152790.1	Ig1_IL1R_like	25..132	CDD:409584	25/151 (17%)
		Ig strand B	43..47	CDD:409584	1/3 (33%)
		Ig strand C	67..71	CDD:409584	1/3 (33%)
		Ig strand E	97..101	CDD:409584	2/11 (18%)
		Ig strand F	111..116	CDD:409584	3/6 (50%)
		Ig strand G	124..127	CDD:409584	0/2 (0%)
		Ig	145..235	CDD:416386	23/105 (22%)
		Ig strand A	145..150	CDD:409353	1/4 (25%)
		Ig strand A	145..150	CDD:409353	1/4 (25%)
		Ig strand B	156..160	CDD:409353	0/3 (0%)
		Ig strand B	156..160	CDD:409353	0/3 (0%)
		Ig strand C	174..179	CDD:409353	0/4 (0%)
		Ig strand C	174..179	CDD:409353	0/4 (0%)
		Ig strand C'	182..184	CDD:409353	1/1 (100%)
		Ig strand C'	182..184	CDD:409353	1/1 (100%)
		Ig strand D	189..193	CDD:409353	0/3 (0%)
		Ig strand D	189..193	CDD:409353	0/3 (0%)
		Ig strand E	195..200	CDD:409353	1/4 (25%)
		Ig strand E	195..200	CDD:409353	1/4 (25%)
		Ig strand F	209..218	CDD:409353	2/8 (25%)
		Ig strand F	209..218	CDD:409353	2/8 (25%)
		Ig strand G	221..234	CDD:409353	4/16 (25%)
		Ig strand G	221..234	CDD:409353	4/16 (25%)
		Ig3_IL1RAP	243..349	CDD:409525	24/105 (23%)
		Ig strand B	262..266	CDD:409525	0/3 (0%)
		Ig strand C	279..283	CDD:409525	1/3 (33%)
		Ig strand E	314..318	CDD:409525	1/3 (33%)
		Ig strand F	329..334	CDD:409525	2/4 (50%)
		Ig strand G	341..344	CDD:409525	0/2 (0%)
		TIR	404..547	CDD:214587	32/159 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910