DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and PXDNL

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_653252.4	Gene:	PXDNL / 137902	HGNCID:	26359	Length:	1463	Species:	Homo sapiens

Alignment Length:	761	Identity:	158/761 - (20%)
Similarity:	263/761 - (34%)	Gaps:	247/761 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 TCQARHKALS--PDMPMRATVQLSVLYP-----PGPPYIEGYSAGETLRRGQTVELMCRSRGGNP 314
            |.:..|..|.  |.:|.:.|| |.:.:.     ||       ||.:.|:...|:.|
Human    34 TVRCMHLMLDHIPQVPQQTTV-LDLRFNRIREIPG-------SAFKKLKNLNTLLL--------- 81

  Fly   315 PAQLIWYKNGSQIRMAYRTSGRLSEN---IYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSV 376
                    |.:.||...|.:....||   :|.:..|.            :.:.:...|..:.|..
Human    82 --------NNNHIRKISRNAFEGLENLLYLYLYKNEI------------HALDKQTFKGLISLEH 126

  Fly   377 LFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSN 441
            |:...:...|...|. .||::.|......:|..::|                   |.|.:   ||
Human   127 LYIHFNQLEMLQPET-FGDLLRLERLFLHNNKLSKI-------------------PAGSF---SN 168

  Fly   442 ITAVVEPNKRSLVVIC----------------HGLNM---------QLTENVVSTHTINVLYPPA 481
            :.::......|..::|                ||...         :|....|::.|:.. :...
Human   169 LDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEE-FNCQ 232

  Fly   482 PPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKN--------DKRIN------SVIRAAD 532
            .|.|:...:...:|:|:.....| .:.|||...:.|..|        |.|:|      .:||...
Human   233 SPRITFEPQDVEVPSGNTVYFTC-RAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTR 296

  Fly   533 KSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPE--ELRPGMEA 595
            :|             :|..|:|.|.|||.|... ||..|.....|......|:|:  |:..|...
Human   297 ES-------------DQGVYQCMARNSAGEAKT-QSAMLRYSSLPAKPSFVIQPQDTEVLIGTST 347

  Fly   596 TIICDSSSSNPPAKLSWWKD-GIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSAN 659
            |:.| .::.:|...::|.:| |:.::|..:.:       |.|.| :..|:||..:|: :||.:.|
Human   348 TLEC-MATGHPHPLITWTRDNGLELDGSRHVA-------TSSGL-YLQNITQRDHGR-FTCHANN 402

  Fly   660 EALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDG 724
            .  ..:...|.::.|...|:|...|....| :|..:::...:...||.||.. |||.|..:|.:|
Human   403 S--HGTVQAAANIIVQAPPQFTVTPKDQVV-LEEHAVEWLCEADGNPPPVIV-WTKTGGQLPVEG 463

  Fly   725 DHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAM 789
            .|.:.: .|:|...|..:.|.|.|.|.|.:|.|               :|.||..:.|.|...|:
Human   464 QHTVLS-SGTLRIDRAAQHDQGQYECQAVSSLG---------------VKKVSVQLTVKPKALAV 512

  Fly   790 LSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTN 854
            .:                ::..|.:|:
Human   513 FT----------------QLPQDTSVE-------------------------------------- 523

  Fly   855 RDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEE 919
                                     .|:...:.|.|||.|:|...|  :|:.:.|..:.|:.|::
Human   524 -------------------------VGKNINISCHAQGEPQPIITW--NKEGVQITESGKFHVDD 561

  Fly   920 RKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITS 965
                    |.||.:......|.|.|||||||..|.||..:.|.:|:
Human   562 --------EGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTA 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	8/23 (35%)
		Ig	197..279	CDD:299845	8/23 (35%)
		IG_like	296..376	CDD:214653	13/82 (16%)
		Ig	300..361	CDD:299845	10/63 (16%)
		Ig	380..454	CDD:299845	12/73 (16%)
		IG_like	490..573	CDD:214653	25/96 (26%)
		Ig	501..560	CDD:299845	17/72 (24%)
		Ig	584..666	CDD:299845	21/84 (25%)
		IG_like	585..666	CDD:214653	20/83 (24%)
		I-set	678..767	CDD:254352	26/88 (30%)
		IGc2	692..757	CDD:197706	21/64 (33%)
		Ig	788..849	CDD:143165	3/60 (5%)
		Ig	885..960	CDD:143165	26/74 (35%)
		FN3	967..1051	CDD:238020
PXDNL	NP_653252.4	LRR 1	51..72		7/28 (25%)
		leucine-rich repeat	52..85	CDD:275378	11/57 (19%)
		LRR_8	53..134	CDD:316378	21/117 (18%)
		LRR 2	75..96		6/37 (16%)
		leucine-rich repeat	86..123	CDD:275378	8/48 (17%)
		LRR 3	99..120		3/32 (9%)
		LRR_8	123..182	CDD:316378	14/81 (17%)
		LRR 4	123..144		4/21 (19%)
		leucine-rich repeat	124..147	CDD:275378	6/23 (26%)
		LRR 5	147..168		5/42 (12%)
		leucine-rich repeat	148..171	CDD:275378	7/44 (16%)
		leucine-rich repeat	172..184	CDD:275378	1/11 (9%)
		LRRCT	180..232	CDD:214507	6/52 (12%)
		Ig_3	234..309	CDD:316449	20/88 (23%)
		Ig_3	329..402	CDD:316449	20/82 (24%)
		Ig	432..505	CDD:325142	25/89 (28%)
		Ig	528..596	CDD:325142	26/77 (34%)
		peroxidasin_like	851..1286	CDD:188658
		VWC	1400..1450	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910