DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP001239

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_321915.5	Gene:	AgaP_AGAP001239 / 1281931	VectorBaseID:	AGAP001239	Length:	299	Species:	Anopheles gambiae

Alignment Length:	291	Identity:	71/291 - (24%)
Similarity:	117/291 - (40%)	Gaps:	41/291 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LRLLAVIVLASAPVPSHAQQ---QKF--RTTPHDLQVLEGAEAMMRCEVANVAG-AVQWTKDG-- 108
            :.|..|:.:.|..|.|:.:|   |.:  .:|..::....|..|::.|.|.|:.. ||.|.:..
Mosquito     7 ITLFPVLNIISGEVQSYWEQPFAQPYFDNSTKREVTATVGQSALLHCRVRNLGDRAVSWIRKRDL 71

  Fly   109 --FALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVG-PARLNSAIRANAKLTV 170
              ..:|. .......|:..|.......:.|||::....|...|:|||. ..:::.|.|.|   .|
Mosquito    72 HILTVGI-LTYTNDQRFQSLHTEGSDEWTLRITSPQPRDSGTYECQVSTEPKISQAFRLN---VV 132

  Fly   171 ISPPASIEIKGYSHNSKVEVRENQDLQLKCI-VANAKPAAQIVWYRGN--VEYKPEKREDTVEES 232
            :|   ..:|.|   ||::.::...|:.|.|: :.:..|.:.|.||:|.  |.|........:.|
Mosquito   133 VS---KAKILG---NSELFIKSGSDINLTCVALQSPAPPSFIYWYKGGRVVNYSQRGGISVLTE- 190

  Fly   233 TAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIE--GYSAGE 295
               |.|.||.|.:......|...|||       ||.....|:|.:.|:....|..::  ..||..
Mosquito   191 ---RQTKTSKLVIARAMPSDSGNYTC-------SPSSSDSASVVVHVINGEQPAAMQHGNSSANS 245

  Fly   296 TLRRGQTVELMCRSRGGNPPAQLIWYKNGSQ 326
            .|...::..    .||..|..:.:.|..||:
Mosquito   246 VLINNRSFS----HRGHGPLDRWLAYLGGSK 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	23/104 (22%)
		Ig	76..155	CDD:299845	20/84 (24%)
		IG_like	186..279	CDD:214653	25/95 (26%)
		Ig	197..279	CDD:299845	23/84 (27%)
		IG_like	296..376	CDD:214653	7/31 (23%)
		Ig	300..361	CDD:299845	6/27 (22%)
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
AgaP_AGAP001239	XP_321915.5	V-set	37..132	CDD:284989	23/98 (23%)
		IG_like	39..131	CDD:214653	22/95 (23%)
		IG_like	147..>213	CDD:214653	18/69 (26%)
		Ig	152..>213	CDD:143165	17/64 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910