DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP001674

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_321421.5	Gene:	AgaP_AGAP001674 / 1281499	VectorBaseID:	AGAP001674	Length:	811	Species:	Anopheles gambiae

Alignment Length:	1006	Identity:	208/1006 - (20%)
Similarity:	352/1006 - (34%)	Gaps:	310/1006 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 PAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSVLFA 379
            ||:::|                          .|.|:.|...|:.:...||:.:|    |.:.|.
Mosquito     2 PARIVW--------------------------AAIDHDAELPCDITAPSSQDGVK----LVLWFK 36

  Fly   380 PTHVTVMGPTEARVGDIVPLTC---TTAPSNPPAEIKWMVGGR------QVRNATSKTIVSPEGG 435
            .:....:...::|.|  ||::.   :|..::....:.:.||..      |:||     |.:.:||
Mosquito    37 DSTGIPLYSLDSRSG--VPISAAQHSTIANDLGQRLFFSVGATPKEARLQIRN-----IKTSDGG 94

  Fly   436 WTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTIN--VLYPPAPPLISGYMEGQIIP--A 496
                              |..|   .:....:....:.:|  :..||..|.|.. .:|:.|.  |
Mosquito    95 ------------------VYRC---RVDYFNSPTRNYRVNLTLAVPPEEPRIFD-AQGKEISTVA 137

  Fly   497 GSVQK-----LLCVSSGGNPLATLTWYKNDKRINSVIR-AADKSVSAEIT--ILANVSDN--QAQ 551
            |..::     |.|..|||.|...:||:::...|:|... :|.:..||.:.  .::.|:.:  .::
Mosquito   138 GPFREGHELFLSCQVSGGRPPPRVTWWRDGVEISSTSHPSAVEGTSAMVNQLFISTVTRDFFGSK 202

  Fly   552 YRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE-LRPGMEATIICDSSSSNPPAKLSWWKD 615
            .:|.|:.|.....:.:...:.||..|..||| |.|.| |..|....|.|::..|.|.||:.|..|
Mosquito   203 LQCRAAGSKLVPAVSKEVAIQVHLKPLRVKI-ISPNELLTAGRPVPIRCEAWGSFPAAKIVWLLD 266

  Fly   616 GIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQ-RSAHEAVSLDVLYRPK 679
            |.|:...:.|.........:::....:.||.|.:|...||:::|.... .|..:...:.|.|.|.
Mosquito   267 GEPLRSADITVHTDSNDANLTSSILTLRVTAENDGAELTCRASNPWFSGGSIEDKRIISVAYEPV 331

  Fly   680 FV-----PPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTR 739
            ..     ..||......|||::.:..:..|.|...::.|.|:...:..:       :|.:|..|:
Mosquito   332 VSVHLSNEDPSRVITRAEGENVTLKCRADARPPVTSFSWYKNNMRMSGE-------NGETLYLTQ 389

  Fly   740 LHRDDAGIYSCSASNSQGGA-TLNITVVVEYGTTIKSVSENIVVNPGEDAM----LSCTVEGKPL 799
            |.|:.||.|:|:|||::|.. :.::|:.:::....|..:|...|  |...|    :.|.||..|.
Mosquito   390 LERESAGSYACAASNTEGETRSSSLTLKIQFAPRCKPGTEQTSV--GSLNMHSLHVKCEVEADPP 452

  Fly   800 TEEHVKWERVGYDMT-----VKTSTTFANG----TSYLHIKDAKREDVGNFRCVADNRVDNPTNR 855
            ......|.   |:.|     |..|...::|    .:||...|:   ::....|.|.|.|...|
Mosquito   453 DGVRFSWT---YNNTRNVSPVLNSRISSHGLVSTMTYLPQSDS---ELVTLACWAINNVGRQT-- 509

  Fly   856 DILLIVKFAP-EIAKTP--------TLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINR 911
             :..::...| :|..||        |:|......|..|.|
Mosquito   510 -VPCLIHILPAKIPDTPRNCELHNDTVLEVVCSAGSDGGL------------------------- 548

  Fly   912 TYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNIL 976
                      :.|...|   :|..|||..|                  .|:.|..| |....|.:
Mosquito   549 ----------MQSFLLE---VVGGVAPPAY------------------NLDYTRGP-PTEFDNEI 581

  Fly   977 NVTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSW 1041
            :..:|..|||          ..:|::.::   .|:|.       |.|..|  |...|.:::|
Mosquito   582 STMNDQATLA----------PLFRIQEQI---PQFKL-------HSLEPG--RDYQLLVYAV--- 621

  Fly  1042 NELGQSS--YLPDLARAETKEAPP-----------------------PSHPASSL-----GGGPP 1076
            |..|:|.  ::.|..|..:...||                       .|.|.:.:     |.|..
Mosquito   622 NAKGKSDPPFVIDKVRVGSALVPPYARKSLQRDRVAQRSRMCSWFAVKSDPVTQMLSHRYGTGNR 686

  Fly  1077 TTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIG---CCLHKRNEKRLKRGLELMPAELTEDSSNT 1138
            ...|:.:     ::...|.|.:.|::.::.|.|   .|       |||:.....|.|:
Mosquito   687 CMRQSQM-----VMFAAVAAAVGVIIASIIVAGFVAIC-------RLKQQKPPEPQEV------- 732

  Fly  1139 PNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETL 1203
                                           ||::     :||:|....|||.....|......|
Mosquito   733 -------------------------------RKRM-----RPARTDVPSMYAEDDVFDDEYQRQL 761

  Fly  1204 ------SSVSEKSESYSNEG---SSQPEYID 1225
                  :|.:.:|..|.:||   .|||...|
Mosquito   762 DVRCSRASSTIRSSRYVSEGFVQYSQPSLND 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	11/60 (18%)
		Ig	300..361	CDD:299845	7/45 (16%)
		Ig	380..454	CDD:299845	13/82 (16%)
		IG_like	490..573	CDD:214653	21/94 (22%)
		Ig	501..560	CDD:299845	16/68 (24%)
		Ig	584..666	CDD:299845	23/83 (28%)
		IG_like	585..666	CDD:214653	22/82 (27%)
		I-set	678..767	CDD:254352	24/94 (26%)
		IGc2	692..757	CDD:197706	19/64 (30%)
		Ig	788..849	CDD:143165	17/73 (23%)
		Ig	885..960	CDD:143165	8/74 (11%)
		FN3	967..1051	CDD:238020	19/85 (22%)
AgaP_AGAP001674	XP_321421.5	Ig	6..115	CDD:299845	26/166 (16%)
		Ig	142..207	CDD:299845	15/64 (23%)
		Ig	234..315	CDD:299845	23/80 (29%)
		IG_like	342..412	CDD:214653	21/76 (28%)
		Ig_2	349..418	CDD:290606	21/75 (28%)
		Ig	439..503	CDD:299845	15/69 (22%)
		FN3	<602..629	CDD:238020	11/38 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810