DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and TOLL6

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_320172.2	Gene:	TOLL6 / 1280328	VectorBaseID:	AGAP012387	Length:	1459	Species:	Anopheles gambiae

Alignment Length:	1103	Identity:	192/1103 - (17%)
Similarity:	314/1103 - (28%)	Gaps:	415/1103 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 SNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINV---LYPPAPPL---------ISGYMEGQ 492
            ::|:.:.||..|       |:|......::|.:..|:   .:...|.|         ||...:|.
Mosquito   497 NSISVIEEPGFR-------GMNNLYGLRLISNNIENITRKAFKDLPSLQILNVARNKISYIEKGA 554

  Fly   493 IIPAGSVQKLLCVSSGGNPLA----------TLTWYK-NDKRINSV--------IRAADKSVSAE 538
            ..||.|||   .:...||.|:          .|.|.. :|.::...        ::..|...: |
Mosquito   555 FEPAVSVQ---AIRLDGNLLSDIDGLFTSMPNLVWLNISDNKLEHFDYSHIPPHLQWLDLHRN-E 615

  Fly   539 ITILAN--VSDNQAQYR-CEAS-NSATEI-PLFQSTTLSVHFAPETVKIRIEPEELRPGMEATII 598
            :|.|.|  ..|||...: .:|| |..|.: |.....::...|..:.:.:.:||.
Mosquito   616 LTELTNRYGLDNQLHLQTLDASFNRLTRVTPATIPNSIEFLFLNDNLIVHVEPH----------- 669

  Fly   599 CDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQE-----------MNGQV 652
            |.:..:                   |.::..|:...:::|:.:....|.           :.|..
Mosquito   670 CFTHKT-------------------NLTRVDLYANQLTSLDIKALRLQPVPEDKQIPEFYIGGNP 715

  Fly   653 YTCQSANEALQRSAH------------EAVSLDVLYRPK--FVP--------------------- 682
            :.|....:.||:..|            |.|...::|..:  ::|
Mosquito   716 FVCDCNIDWLQKINHVTSRQYPTINDIETVYCKLMYNRERSYIPLIEAEPKHFLCSYNTHCFALC 780

  Fly   683 --------------PPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGG 733
                          |.:.........|..:...:.|..|.:......|.|.:..||::.:...|.
Mosquito   781 HCCEFDACDCEMTCPNNCACYHDNSWSTNIVECSAAGYTDIPNNIPMDTTEVYIDGNNLVELSGH 845

  Fly   734 SLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVN------PGEDAMLSC 792
            |.    :.|.:..:...:.||.:  |..|.|.:.....||..:..|.:..      ...:::...
Mosquito   846 SF----IGRKNLRVLYANHSNIE--AIYNTTFIGLRRLTILHLENNAIRKLYGHEFSALESLREL 904

  Fly   793 TVEGKPLT--EEHV-----KWERVGYDMTVKTS--------------TTFANG------------ 824
            .::|..:.  |:|.     |.|.:..|....||              ...||.
Mosquito   905 YLQGNRIAYIEDHTFAELRKLEVLRLDGNRITSFEVWQLSANPYLVEIALANNLWTCDCGFVNKL 969

  Fly   825 TSYLHIKDAKREDVGNFRCVADNRV----DNPTN---RDILLIVKFAPEIAKTPTLLRAA----- 877
            .|||.....|..|.....|..:|..    ||.|.   |:.:..:....||.....||..|
Mosquito   970 RSYLQSNADKIVDANEISCSYNNATSILRDNGTKCTFREGMSSIVHRQEIEDMLPLLLVATCAFV 1034

  Fly   878 ---------------------SGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTY----KYEV 917
                                 ||.       |...|:    |:...||     :|.|    .|.:
Mosquito  1035 GFFGLIFGIFCYRKELKVWVHSGL-------CYKSGT----FVNEYDK-----DRLYDAYITYSL 1083

  Fly   918 EERKIDSLTYESTLIVDKVAPADYGAYECVARNELG----------EAVETVRLEITSQPDPPLS 972
            ::....|....|||      ..|.|...|:...:|.          ||||:.:..
Mosquito  1084 QDEHFVSQILTSTL------ENDIGFRLCLHYRDLNANAYLADTIVEAVESSKRA---------- 1132

  Fly   973 LNILNVTHDTVTLAWTP-GFDGGLKASYRVRYRM--------------ADREQYKYIDGLPNSHK 1022
              ||.::...:...||. .|.|.:....:.|.::              ||...|
Mosquito  1133 --ILVLSKSFLYNEWTRFEFKGAIHEVLKRRRKLIIILYGDLPQRDLDADMRLY----------- 1184

  Fly  1023 LTIGGLRMNT--------------LYLFSVMSWNELGQSSYLPDLARAETKEAPPPSHPASSLGG 1073
                 ||.||              :.|..|...|.|.:.|.:...|.| ..:...|..| |:||
Mosquito  1185 -----LRTNTCIEWDDKKFWQKLRIALPHVKKSNCLNKRSAINIYATA-GNDYNTPGRP-STLG- 1241

  Fly  1074 GPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNT 1138
              |:.:.|.|.|........:|........|...:..|.:...:...
Mosquito  1242 --PSVASTRLDGPQHHSYATIGPNCPRNCDNYDTVSNCKYNTTQHHQ------------------ 1286

  Fly  1139 PNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPS---------SY 1194
                                       .|..|:..|:...:.......|...||         :|
Mosquito  1287 ---------------------------THHERRTTADFGRKATDGRQHEYAVPSNCLLDTTHETY 1324

  Fly  1195 NDTVT------GETLSSVSEKSE-SYSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQKDGT 1252
            |.|.|      |||....|..|: |.|:.||........:  .:|:.:..:||...|     :|.
Mosquito  1325 NTTATSCERIAGETFECTSTSSKFSTSSRGSGSDSGSHSI--SSAAQHDFQGSHRSP-----NGC 1382

  Fly  1253 LPVIYPNNVVNACTL--------PHP-RHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDG 1306
            .|     |::::.|.        ||| .|:|||..                    |..|.|:|
Mosquito  1383 AP-----NLLSSTTSTTNFSYQHPHPHHHHNGSGR--------------------SKPPGPEG 1420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845	4/13 (31%)
		IG_like	490..573	CDD:214653	25/106 (24%)
		Ig	501..560	CDD:299845	17/81 (21%)
		Ig	584..666	CDD:299845	11/92 (12%)
		IG_like	585..666	CDD:214653	11/91 (12%)
		I-set	678..767	CDD:254352	17/125 (14%)
		IGc2	692..757	CDD:197706	12/64 (19%)
		Ig	788..849	CDD:143165	17/93 (18%)
		Ig	885..960	CDD:143165	20/88 (23%)
		FN3	967..1051	CDD:238020	19/112 (17%)
TOLL6	XP_320172.2	LRR_RI	94..355	CDD:238064
		leucine-rich repeat	119..142	CDD:275380
		LRR_8	<162..207	CDD:290566
		leucine-rich repeat	173..196	CDD:275380
		LRR_8	247..305	CDD:290566
		leucine-rich repeat	247..270	CDD:275380
		leucine-rich repeat	271..294	CDD:275380
		LRR_8	293..354	CDD:290566
		leucine-rich repeat	295..319	CDD:275380
		LRR_RI	298..549	CDD:238064	11/58 (19%)
		leucine-rich repeat	320..343	CDD:275380
		leucine-rich repeat	344..369	CDD:275380
		LRR_8	369..428	CDD:290566
		leucine-rich repeat	370..393	CDD:275380
		leucine-rich repeat	394..417	CDD:275380
		LRR_8	417..476	CDD:290566
		leucine-rich repeat	418..441	CDD:275380
		leucine-rich repeat	442..465	CDD:275380
		leucine-rich repeat	466..488	CDD:275380
		leucine-rich repeat	489..512	CDD:275380	5/21 (24%)
		LRR_8	512..571	CDD:290566	14/61 (23%)
		leucine-rich repeat	513..534	CDD:275380	2/20 (10%)
		leucine-rich repeat	537..560	CDD:275380	6/22 (27%)
		LRR_8	560..616	CDD:290566	10/59 (17%)
		leucine-rich repeat	561..583	CDD:275380	5/24 (21%)
		LRR_8	630..687	CDD:290566	11/86 (13%)
		leucine-rich repeat	631..676	CDD:275380	9/74 (12%)
		leucine-rich repeat	829..852	CDD:275380	6/26 (23%)
		LRR_8	851..911	CDD:290566	9/61 (15%)
		LRR_RI	<852..962	CDD:238064	18/111 (16%)
		leucine-rich repeat	853..876	CDD:275380	5/24 (21%)
		leucine-rich repeat	877..900	CDD:275380	3/22 (14%)
		LRR_8	900..958	CDD:290566	10/57 (18%)
		leucine-rich repeat	901..924	CDD:275380	3/22 (14%)
		TIR	1075..1208	CDD:214587	29/166 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910