DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP010222

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_554133.3	Gene:	AgaP_AGAP010222 / 1279645	VectorBaseID:	AGAP010222	Length:	370	Species:	Anopheles gambiae

Alignment Length:	374	Identity:	92/374 - (24%)
Similarity:	147/374 - (39%)	Gaps:	108/374 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   659 NEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQV----SLQTRANPTPVTYK--WTK-D 716
            ::|::.:....:..|:   |||..|..:..|.|..|::..    :||        |||  |.: |
Mosquito    32 DDAIEETNSYILDKDL---PKFGEPIQNLTVPVGREAVLTCVINNLQ--------TYKVAWLRVD 85

  Fly   717 GTTIPQDGDHRIFADGGSLNFTRLHR--------------------DDAGIYSCSAS----NSQG 757
            ..||.....|.|         |:.||                    .|.|.|.|..:    .:|.
Mosquito    86 TQTILTIQTHVI---------TKNHRMTIAHVEGRAWVLRIRDVKESDKGWYMCQVNTDPMRNQI 141

  Fly   758 GATLNITV---VVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYD------- 812
            | .||:.|   :::|.|     |.::||..|.:..|.|...|.|...  :.|.|.|.:
Mosquito   142 G-YLNVVVPPNILDYPT-----STDMVVREGSNVTLKCAASGSPTPS--IIWRREGNEPISAGGR 198

  Fly   813 -------MTVK-TSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAK 869
                   ||.. .|:||:       |....|..:|.:.|:|.|.:....::.::|||.|.|.|..
Mosquito   199 TGVYWVVMTTSLNSSTFS-------ISRVNRLHMGAYLCIASNGIPPSVSKRVMLIVHFPPMIWI 256

  Fly   870 TPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQD-------------KKD-LPINR-------TY 913
            ...|:.||  .|:|..|.|:::..|:....|.::             |.| |.||.       |.
Mosquito   257 QDQLVGAA--LGQRLTLECQSEAYPRSINYWMKNDTIITQVQTNNKHKHDQLTINNERCNIISTG 319

  Fly   914 K-YEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRL 961
            | :|...::|:|......|.:..:..||:|.|:||.:|.|||...::::
Mosquito   320 KHFEPSIKEINSYKVVMKLTIKDINIADFGTYKCVVKNSLGETDGSIKV 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845	1/6 (17%)
		IG_like	585..666	CDD:214653	1/6 (17%)
		I-set	678..767	CDD:254352	30/122 (25%)
		IGc2	692..757	CDD:197706	19/95 (20%)
		Ig	788..849	CDD:143165	18/75 (24%)
		Ig	885..960	CDD:143165	25/96 (26%)
		FN3	967..1051	CDD:238020
AgaP_AGAP010222	XP_554133.3	IG_like	55..148	CDD:214653	25/110 (23%)
		Ig	55..146	CDD:299845	24/108 (22%)
		IG_like	158..248	CDD:214653	23/98 (23%)
		IGc2	165..234	CDD:197706	18/77 (23%)
		IG_like	263..369	CDD:214653	29/108 (27%)
		Ig	269..367	CDD:143165	25/97 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910