DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP010184

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_319362.3	Gene:	AgaP_AGAP010184 / 1279605	VectorBaseID:	AGAP010184	Length:	771	Species:	Anopheles gambiae

Alignment Length:	671	Identity:	172/671 - (25%)
Similarity:	269/671 - (40%)	Gaps:	111/671 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 SVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATE 562
            |...|.|.......:..:.|.:|.:.|:|......:.||.:         :...|.|.|.|...:
Mosquito    18 STAVLECAVDSKPKVPNVRWTRNGRIISSSHSHPIQRVSVQ---------DAGNYACAADNGLGK 73

  Fly   563 IPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSK 627
            |. .|..||.|.:|| .|.|..:..|.......||.|:.:|:.||..:.|:|:|.|
Mosquito    74 IG-EQIITLDVLYAP-IVVIESKTWEAEERSTVTIRCNVTSNPPPVSIEWFKEGSP--------- 127

  Fly   628 PGLWGGTVSTLEFRVNVTQEMNGQVYTCQSAN-------EALQRSAHEAVSLDVLYRP-KFVPPP 684
            ...:.|.:  |:.| :|..|..|: |.|::.|       :.::|..:..|:|.|.:|| :....|
Mosquito   128 DFRYAGDI--LQLR-DVKAEHAGR-YVCRAVNMMKPYNGKIVERVGNSTVALLVRHRPGQAYINP 188

  Fly   685 SSTAVGVEGESLQVSLQTRANPT--PV-TYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAG 746
            |...|.| |..  |:|...|||.  || .::|.||... .|.....|.|.|......|.|....|
Mosquito   189 SKPIVHV-GNG--VTLTCSANPPGWPVPQFRWFKDAVG-EQQTPKTILAQGTQYVIPRAHLGSEG 249

  Fly   747 IYSCSASNSQGG---ATLNITVVVEYGTTIKSVSENIVVNPGE-DAMLSCTVEGKPLTEEHVKWE 807
            .|.|.|.|..|.   ||:|:. |.:....|..:.:::....|: |...:|..:|||  ...|:|.
Mosquito   250 SYHCHAVNEMGSGPMATINLE-VHQPPQFIGKMQQHMTKRIGDTDFSATCHAKGKP--RPMVRWL 311

  Fly   808 RVGYDMTVKT--------------------STTFANGTSYLHIKDAKREDVGNFRCVADNRVDNP 852
            :.|.|:|...                    ||....|.:..|.......|.|.:.|:.:|.| :.
Mosquito   312 KDGRDITTDANMYRISTNNNDGLSGMVTVQSTLLFQGKARPHKNQLLPSDRGTYTCLFENEV-ST 375

  Fly   853 TNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWR--QDKKDLPINRTYKY 915
            .|..:.|.::..|.:.....  :.|....|...:.||.|..|||:|.|:  .:...|.::....|
Mosquito   376 ANASMNLRIEHGPIVLHQYN--KVAYEINENAAVMCRVQAYPKPEFQWQLGTNTAALSMSADEHY 438

  Fly   916 EVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQ----PDPPLSLNIL 976
            |:.....::..|.|.|.:::|...|||.|.|    .:|.::||:|..|..|    |:.|.:|.:.
Mosquito   439 EINTTTDNNDIYTSVLRINRVKHEDYGDYTC----RVGNSIETIRAPIRLQPKGPPEKPTNLGVA 499

  Fly   977 NVTHDTVTLAWTPGFDGGL-KASYRVRYR---MADREQYKYIDGL-------------PNSHKLT 1024
            :|..:.|:|.|.||||||: ...:.|.||   :...:|.|...|:             ......:
Mosquito   500 DVGSNYVSLVWDPGFDGGITNTKFFVSYRKVAIPHHDQVKEDCGIVQQVSSEWMEYDCQRDVPCS 564

  Fly  1025 IGGLRMNTLYLFSVMSWNELGQSSYLPDLA-RAETKEAPPPSHPASSLGGGPPTTSQTPLGGTSG 1088
            :..|.....|:|.|.:.|..|.|....::| ..:..:.|.|.|.     |..|.|.|  ||
Mosquito   565 VTPLDQYQSYVFKVKAINSKGNSEPSNEVATTTKISKIPVPLHV-----GFDPDTKQ--LG---- 618

  Fly  1089 MLLVGVGAGIVVVLLNVFVIG 1109
               :.:||..:.::..|..||
Mosquito   619 ---LNIGATCLALIAVVETIG 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	17/74 (23%)
		Ig	501..560	CDD:299845	12/58 (21%)
		Ig	584..666	CDD:299845	21/88 (24%)
		IG_like	585..666	CDD:214653	21/87 (24%)
		I-set	678..767	CDD:254352	31/95 (33%)
		IGc2	692..757	CDD:197706	22/67 (33%)
		Ig	788..849	CDD:143165	17/80 (21%)
		Ig	885..960	CDD:143165	23/76 (30%)
		FN3	967..1051	CDD:238020	26/100 (26%)
AgaP_AGAP010184	XP_319362.3	IG_like	11..83	CDD:214653	17/74 (23%)
		IGc2	17..72	CDD:197706	13/62 (21%)
		IG_like	93..164	CDD:214653	20/83 (24%)
		IGc2	102..155	CDD:197706	18/65 (28%)
		Ig_2	186..271	CDD:290606	30/89 (34%)
		IG_like	188..271	CDD:214653	30/87 (34%)
		I-set	275..382	CDD:254352	22/109 (20%)
		Ig	297..381	CDD:143165	19/86 (22%)
		IG_like	403..485	CDD:214653	26/85 (31%)
		Ig	409..483	CDD:143165	24/77 (31%)
		FN3	490..597	CDD:238020	27/106 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810