DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP009683

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_318742.4	Gene:	AgaP_AGAP009683 / 1279073	VectorBaseID:	AGAP009683	Length:	679	Species:	Anopheles gambiae

Alignment Length:	898	Identity:	174/898 - (19%)
Similarity:	281/898 - (31%)	Gaps:	341/898 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 GQTVELMCRSRGGNPPAQ-----LIWYKN------------GSQIRMAYRTSG------RLSENI 341
            |:.:.|.|..   :.|::     ::|:|:            |..::.|...|.      |...|.
Mosquito    11 GRKISLPCPL---SAPSRDKVYMVLWFKDDAGIPLYSFDVRGKPLQQARHWSAPEIFGPRAHFNT 72

  Fly   342 YTFTAEAGDNKAR------FRCEASNVMSQNPLKAEVELSVLFAPTHVTV------------MGP 388
            .|..|.......|      :||......||.. .....||::..|.|..|            :||
Mosquito    73 DTDPATLDIQDVRRHDEGVYRCRVDFRTSQTQ-SFRYNLSIIILPEHPVVLSQWGQQLNSSKLGP 136

  Fly   389 TEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSL 453
            .|.  ||.:.|||......|...:||::.|         .:|..:            .|.|...:
Mosquito   137 KEE--GDDIVLTCRVVGGRPQPSVKWLING---------ILVDEQ------------YEHNSGDV 178

  Fly   454 VVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWY 518
            :           ||       .:|:|                  ::|:
Mosquito   179 I-----------EN-------RLLWP------------------AIQR----------------- 190

  Fly   519 KNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIR 583
                                       ||..:.:.|:|:|:....|...|..|.:|..|.:|||.
Mosquito   191 ---------------------------SDLNSIFTCQATNTLLVEPKESSFVLDLHLKPLSVKIM 228

  Fly   584 IEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPI----EGINNTSKPGLWGGTVSTLEFRVNV 644
            .....|.......|.|:|..|.|.|.::|:|....:    |.:|||::        |.|.| |..
Mosquito   229 NPQTPLVADRRYEISCESVGSRPNAIITWYKGKRQLRRAKEILNNTTR--------SELSF-VPT 284

  Fly   645 TQEMNGQVYTCQSANEALQRSAHE-AVSLDVLYRPKFVPPPSSTAVG--------VEGESLQVSL 700
            |:: :|:..||::.|..:.....| :..::|:|     ||..|..:|        .||:.:....
Mosquito   285 TED-DGKQITCRAENPNVTGLFLETSWKIEVVY-----PPIVSLRLGSTLSADDIKEGDDVYFEC 343

  Fly   701 QTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITV 765
            ..:|||......|..||..|..:...|:.....||...::.|:.:|.|||||.|::|
Mosquito   344 HVQANPPWRKLHWLHDGVMITHNATARVIRSNQSLVLQKVTRNSSGNYSCSAINAEG-------- 400

  Fly   766 VVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHI 830

Mosquito   401 ----------------------------------------------------------------- 400

  Fly   831 KDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPK 895
                 |.|.|               .:.|.||:|| :..|..::...:...|..::||.....|.
Mosquito   401 -----ETVSN---------------QLALRVKYAP-VCATDRIIIVGAFRSESLQIPCEVHADPP 444

  Fly   896 P-QFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELG------ 953
            | ||.|:.:.....:....:..|:...|..|.|      ..|:..|||...|..:||:|
Mosquito   445 PRQFNWKFNNSGETLKIGKERYVKNGSISLLNY------IPVSDQDYGTLTCWGQNEVGTQDWPC 503

  Fly   954 --EAVETVRLEI------------TSQPDPPL---------SLNILNVTHDTVTLAWTPGFDGGL 995
              :.|...:..:            :|||...|         :.:|.|.|..:|.:...||:||||
Mosquito   504 FFQVVLAAKFSLMLTLFLHARDCSSSQPFTTLHTGLPSAVKNCSINNQTQHSVEVQCLPGYDGGL 568

  Fly   996 KASY----------RVRYRMAD-REQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSY 1049
            ...:          ||||.:.: .|.|..::.|.|  .:..||            :::::|..:.
Mosquito   569 PQIFILEVISSRTGRVRYNVTNPDEPYFLVESLEN--LIHYGG------------AYDDIGDDNP 619

  Fly  1050 LPDLARA----------ETKEAPPPSHPASSLGGGPPTTSQTPLGGTSGMLLV 1092
            |..:..|          ..|:....|...:..||..|.|..|..|.:...|||
Mosquito   620 LKAIIYAVNQKGRSQGIVVKDFYLESAVENRAGGIRPITPFTAAGASFSHLLV 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	19/104 (18%)
		Ig	300..361	CDD:299845	16/89 (18%)
		Ig	380..454	CDD:299845	18/85 (21%)
		IG_like	490..573	CDD:214653	9/82 (11%)
		Ig	501..560	CDD:299845	5/58 (9%)
		Ig	584..666	CDD:299845	22/85 (26%)
		IG_like	585..666	CDD:214653	22/84 (26%)
		I-set	678..767	CDD:254352	25/96 (26%)
		IGc2	692..757	CDD:197706	20/64 (31%)
		Ig	788..849	CDD:143165	3/60 (5%)
		Ig	885..960	CDD:143165	20/83 (24%)
		FN3	967..1051	CDD:238020	23/103 (22%)
AgaP_AGAP009683	XP_318742.4	V-set	3..112	CDD:284989	19/104 (18%)
		IG_like	3..96	CDD:214653	16/87 (18%)
		Ig	140..203	CDD:299845	21/163 (13%)
		Ig	241..314	CDD:299845	22/82 (27%)
		IG_like	241..314	CDD:214653	22/82 (27%)
		IG_like	334..405	CDD:214653	23/148 (16%)
		IGc2	335..400	CDD:197706	20/64 (31%)
		ig	429..501	CDD:278476	20/77 (26%)
		IG_like	431..498	CDD:214653	19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810