DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP009596

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_318623.4	Gene:	AgaP_AGAP009596 / 1278969	VectorBaseID:	AGAP009596	Length:	658	Species:	Anopheles gambiae

Alignment Length:	831	Identity:	161/831 - (19%)
Similarity:	284/831 - (34%)	Gaps:	298/831 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 PYIEGYSAGETLRRGQTVELMCRSRGGNPPAQ---LIWYKNGSQIRM-AYRTSGRLSENIYTFTA 346
            |:.:.:|....  .|::|||.|...  .|.:|   ::|:|:.:.|.: :.....::|.....::|
Mosquito     6 PFADVFSVEGV--EGRSVELHCPIT--VPLSQVYMVLWFKDNAGIPLYSVDVRDKISRQPAHWSA 66

  Fly   347 -EAGDNKARFRCEASNVM---------SQNPLKAEVE------------LSVLFAP--------- 380
             |...::|:|..:.|...         .|...:..::            |||:..|
Mosquito    67 PEVFGSRAKFNIDKSPASLLIKNLKRHDQGVYRCRIDFRTIQTQTYRYNLSVIVLPEQPVVLDRW 131

  Fly   381 -THV--TVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNI 442
             .|:  |.:||.|.  ||.|.:||..:...|..|::|::.|         .||..:
Mosquito   132 GRHLNGTKLGPKEE--GDDVVITCRVSGGRPQPEVRWLING---------VIVDDQ--------- 176

  Fly   443 TAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSS 507
               .|.|...::           ||       .:|:|                  ::|:
Mosquito   177 ---YEQNSGDVI-----------EN-------RLLWP------------------TIQR------ 196

  Fly   508 GGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLS 572
                                                  ||..|.:.|:..|:....|...|..|.
Mosquito   197 --------------------------------------SDLNAIFTCQTMNTKLVEPKETSYVLD 223

  Fly   573 VHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPI-----EGINNTSKPGLWG 632
            :|..|.|:|:...|..|.......|:|.|:.|.|.|.::|:|....:     |.:::.:
Mosquito   224 MHLKPLTIKVINPPATLVADKRYEIVCQSTGSRPNAIITWYKGKRQMRRTRDETVDHNT------ 282

  Fly   633 GTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSST-AVG------ 690
             |.|||.|.  .|.|.:|:..||::.|..:     ..:.|:..::...|.||..| .:|
Mosquito   283 -TTSTLSFA--PTTEDDGKTLTCRAENPNV-----NGLFLETDWKMNVVYPPMVTIQLGPTLVVD 339

  Fly   691 --VEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSAS 753
              .||:.:......||||.....:|..:...:..:|..||...|.||...::.:..||.|:|||.
Mosquito   340 DIKEGDDVYFECHVRANPDWKRLQWFHNDVLLQYNGSARIIQSGQSLVLQKVTKQSAGYYACSAI 404

  Fly   754 NSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTS 818
            |::|                ::||:                      ::|::.:|
Mosquito   405 NAEG----------------ETVSD----------------------QQHLRVKR---------- 421

  Fly   819 TTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGER 883
                                              .||:.:||                .:...|.
Mosquito   422 ----------------------------------NNRNAILI----------------GASRNEN 436

  Fly   884 GRLPCRAQGSPKPQ-FIWR--QDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYE 945
            ..:||.....|..: |.||  ...:.||:: .::| ..:..|..|.|.      .|...|:|...
Mosquito   437 VEIPCHIFADPPARSFHWRFNNSAEILPVD-AHRY-TSQGNISILNYA------PVTDQDFGTLT 493

  Fly   946 CVARNELGEAVE--TVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGL----------KAS 998
            |.|.||:|...:  |.:|.:...|.|..:.::.|.|.....:..|||:||||          |.:
Mosquito   494 CWAVNEVGPQSQPCTFQLVLADLPSPVSNCSLPNRTQQFAEIQCTPGYDGGLPQVFVLELVSKRT 558

  Fly   999 YRVRYRMADREQYKYIDGLPNSHKLT-IGGLRMNTLYLFSVMSWNELGQSS 1048
            ...|:..:::.:..::  |....||: :..|..|:|... |.:.|:.|:|:
Mosquito   559 GTRRFNFSNKNEPFFV--LDRLEKLSALMTLENNSLSCV-VYAINQKGRST 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	18/105 (17%)
		Ig	300..361	CDD:299845	15/65 (23%)
		Ig	380..454	CDD:299845	19/85 (22%)
		IG_like	490..573	CDD:214653	9/82 (11%)
		Ig	501..560	CDD:299845	5/58 (9%)
		Ig	584..666	CDD:299845	22/86 (26%)
		IG_like	585..666	CDD:214653	22/85 (26%)
		I-set	678..767	CDD:254352	26/97 (27%)
		IGc2	692..757	CDD:197706	20/64 (31%)
		Ig	788..849	CDD:143165	2/60 (3%)
		Ig	885..960	CDD:143165	21/79 (27%)
		FN3	967..1051	CDD:238020	23/93 (25%)
AgaP_AGAP009596	XP_318623.4	V-set	12..118	CDD:284989	19/109 (17%)
		IG_like	12..101	CDD:214653	18/92 (20%)
		Ig	146..209	CDD:299845	22/163 (13%)
		Ig	234..308	CDD:299845	22/82 (27%)
		IG_like	247..310	CDD:214653	20/76 (26%)
		IGc2	343..408	CDD:197706	20/64 (31%)
		IG_like	431..508	CDD:214653	21/84 (25%)
		ig	431..504	CDD:278476	21/80 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810