DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP008655

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_314755.4	Gene:	AgaP_AGAP008655 / 1275506	VectorBaseID:	AGAP008655	Length:	408	Species:	Anopheles gambiae

Alignment Length:	455	Identity:	97/455 - (21%)
Similarity:	173/455 - (38%)	Gaps:	86/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   535 VSAEITILA---NVSDNQAQ---YRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGM 593
            :||:...||   |::..|.:   :.|..:|    :..:::.|.|.|..|:...|:.:.:.:
Mosquito    12 LSAQPEFLAPLDNLTVTQGRDVSFTCVVNN----LGQYRTLTTSTHVYPQVAWIKSDSKAI---- 68

  Fly   594 EATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSA 658
             ..|.....:.||  :||...:|      :||     |       :..::..|..:...|.||..
Mosquito    69 -LAIHTHMVALNP--RLSVTHNG------HNT-----W-------KLHISHVQLNDSGSYMCQVN 112

  Fly   659 NEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQD 723
            .:.::   |:..:|:............|..:..:.:.|::....:.||...:.:        |..
Mosquito   113 TDPMR---HQVSALNESEGKTSTASSLSAGLVCKIQCLKMCTHKKNNPHHQSPR--------PNS 166

  Fly   724 GDHRIFADGGSLNFTRLHRDDAGIYSCSA------SNSQGG-----ATLNITVVVEYGTTI---K 774
            |..           ..:.|:::.:..|.|      |:...|     ||......|.|..:.   .
Mosquito   167 GQR-----------FNVSRNESVLGCCFAFLSAFPSHQPNGPAQHEATRTPVYAVPYALSCINEP 220

  Fly   775 SVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERV-GYDMTVKTS------TTFANGTSYLHIKD 832
            :..|..|.|.|.:..|.|...|.|  |..|:|.|. |.|:.|:|.      ..|..| ..|.:..
Mosquito   221 NTLEGGVANEGGNVQLVCQATGVP--EPAVQWRRENGKDIVVRTEGREKQVVKFVEG-ERLVLNQ 282

  Fly   833 AKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQ 897
            .:|.|:|.:.|:|.|.|....::...:.|.|.|.:.....|:  |:.......|.|..:..|.|.
Mosquito   283 VQRTDMGGYLCIASNGVPPSVSKRFDVQVNFPPNVKAGNQLV--AAPVESHVLLQCIVEAFPTPL 345

  Fly   898 FIWRQDKKD-LPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRL 961
            ..|.  |.| :.:....||.:.|.|:::.|::..|.|..:...|:|.|.|.:.|.||::...:||
Mosquito   346 NGWH--KHDGMKLYEGEKYTISEEKLNAYTWQLNLTVKNLHKGDFGPYICSSINALGKSDARIRL 408

Fly 962 961
Mosquito 409 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	9/43 (21%)
		Ig	501..560	CDD:299845	8/30 (27%)
		Ig	584..666	CDD:299845	13/81 (16%)
		IG_like	585..666	CDD:214653	13/80 (16%)
		I-set	678..767	CDD:254352	13/99 (13%)
		IGc2	692..757	CDD:197706	9/70 (13%)
		Ig	788..849	CDD:143165	21/67 (31%)
		Ig	885..960	CDD:143165	21/75 (28%)
		FN3	967..1051	CDD:238020
AgaP_AGAP008655	XP_314755.4	I-set	16..134	CDD:254352	26/149 (17%)
		Ig	25..111	CDD:299845	20/114 (18%)
		IG_like	227..311	CDD:214653	25/86 (29%)
		IGc2	230..299	CDD:197706	22/71 (31%)
		Ig	314..408	CDD:299845	24/97 (25%)
		IG_like	332..408	CDD:214653	21/77 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910