DRSC/TRiP Functional Genomics Resources

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Protein Alignment sns and AgaP_AGAP003656

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:XP_313432.5 Gene:AgaP_AGAP003656 / 1274328 VectorBaseID:AGAP003656 Length:4085 Species:Anopheles gambiae


Alignment Length:1410 Identity:309/1410 - (21%)
Similarity:487/1410 - (34%) Gaps:384/1410 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 LQVLE-GAEAMMRCEVANVAGA----VQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISN 140
            ::::| |.:....|...:|...    ||||:....|..||...|              ..|.|:|
Mosquito  2311 IKIVEIGEDFRADCTAHHVVSQSPIDVQWTRKNGRLPDSAYTDG--------------GTLVITN 2361

  Fly   141 ASINDDADYQCQVG--------PARLNSAIRANAKLTV-ISPPASIEIKGYSHNSKVEVRENQDL 196
            ..|.|...|.|:..        ...:|.:.:.:||.|| :|.|.            ::..|:...
Mosquito  2362 IQIKDGGLYVCKASSGTEVVYKQVTINVSKQGSAKPTVLLSQPF------------IDQDEHLSA 2414

  Fly   197 QLKCIVANAKPAAQIVWYRGN--VEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQ 259
            ::.| .|...|...|.|.|.:  :.|      ..|.|....||   |:|:     ..|...|.|.
Mosquito  2415 EVLC-TATGYPTPTITWERVDQPLPY------HAVTERGLLRF---SALR-----QQDAGTYRCV 2464

  Fly   260 ARHKALSPDMPMRATVQLSV--LYPPGPP----YIEGYSAGETLRRGQTVELMCRSRGGNPPAQL 318
            ||:.....|..:...|:.:|  ..||..|    .:|...:....:.|:.:.|:||.   :|.||:
Mosquito  2465 ARNDVGESDTLLTVYVRPAVGPTLPPSYPTEMERVEISPSSFDGQPGEVIRLICRC---SPTAQV 2526

  Fly   319 IWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEA------------------SNVMSQ 365
            :|.|.|.:   ...::..:...:......:.:|..|:.|.|                  :||:..
Mosquito  2527 VWSKLGER---QLPSNADVRNEMLIIEHASQENTGRYSCTAYFPNGRTKTSTVDVVIADNNVLPP 2588

  Fly   366 --------NPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVR 422
                    |||.          ..:|.:.|..       ..|:| .|...|...:||.:.|:   
Mosquito  2589 SNKVAPRVNPLN----------KNYVVLQGAD-------FSLSC-EATGTPYPTVKWTLSGK--- 2632

  Fly   423 NATSKTIVSPEGGWTTTSNITAV--VEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLI 485
              |.::.|...|      |:..:  .:|:... |.||...|   .|.:...:|:..:.....|::
Mosquito  2633 --TFESNVQQSG------NVLRIFNAQPSNGG-VYICVASN---EEGMDRAYTVVEIDRREKPVL 2685

  Fly   486 SGY-MEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKR---------INSVIRAADKSVSAEIT 540
            ..| .|.|.|..|...:|.|.:|.|.|..::||.:.|:.         ...||...|.|:     
Mosquito  2686 EIYPSEPQTIKVGESVRLSCRASAGVPYPSITWVRKDRMPLSSRFTNDAEGVITLRDASL----- 2745

  Fly   541 ILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE---LRPGMEATIICDSS 602
                  ::..:|.|.|.|:|....|  |||:.|...|   .||::|.|   :....|.||.|  |
Mosquito  2746 ------EDAGEYECRADNAAGSAIL--STTIEVLQPP---IIRLQPSESHKITENDEFTIHC--S 2797

  Fly   603 SSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQ-EMN-GQVYTCQSANEALQRS 665
            ::..||.:...   :|..|   .|:..|...|....|..:.:.| |:| ...|.|.:.|.|.:.|
Mosquito  2798 ATGKPAPMVTL---LPPPG---ASRSHLRQQTEGLREVTLYLHQAELNDAGTYECTAKNAAGEDS 2856

  Fly   666 AHEAVSLD---------------VLYRPKFVPP-----PSS-----TAVGVEGES--LQVSLQTR 703
            .:.::.:|               ..|.|..:||     |||     |...:.||.  |..:.:.|
Mosquito  2857 QYLSLQVDPKRGDVGPHDDDDRPPSYYPPRLPPTRPPGPSSQPIAYTYKAILGEQAHLMCNEEFR 2921

  Fly   704 ANPTPVTYKWTK-DGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVV 767
            :..|    :|.: ||..:|.....|    ||:|.......|.||:|.|....|.......:.::|
Mosquito  2922 STRT----EWRRSDGRPLPYGSIVR----GGNLTIESTGHDAAGMYDCVTFPSPSQPVTIVRIMV 2978

  Fly   768 EYGTTIK---SVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLH 829
            |..:..|   |....:.|.||:...:.|.|......|  |||.|  .|......|..|.| :||.
Mosquito  2979 EVISLPKISFSPQMPMTVRPGDAVDILCNVTSDVAYE--VKWHR--KDNLPLPPTVQAYG-NYLR 3038

  Fly   830 IKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCR-AQGS 893
            ......||.|.:.|...|:. ..|.:...::|.  .:.|...:|....:..|...||.|: ..|:
Mosquito  3039 FSSIAPEDAGRYYCHVRNQF-GETEKAAEVVVN--SKHAFVTSLRYHQASLGAAIRLDCKLPAGA 3100

  Fly   894 P--KPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAV 956
            |  ..::.|.:.::.||  .|.:.....|::.....|         |.|.|.|:|......|..|
Mosquito  3101 PYVNVRYNWNRLERTLP--PTARIVANGRELHLFNLE---------PEDAGTYQCGMSYPDGTVV 3154

  Fly   957 -ETVRLEITSQPDPPLSLNILNVTHDTVTL----------AWTPG----FDGGLKASYRVRYRMA 1006
             :::.|..|....||.|...|:|.....:|          ...||    .|....|...|..:  
Mosquito  3155 YDSIVLTFTCANLPPTSAYYLSVFIPPESLPVLQLEPSRSMVRPGESLVVDCSSSAGTGVPIK-- 3217

  Fly  1007 DREQYKYIDGLP---NSH----KLTIGGLRMNTLYLFSVMSWNELGQ---------------SSY 1049
                ::..||.|   |.|    :|.|...|.:....::.:.:.|.|.               |..
Mosquito  3218 ----WEKSDGTPLPYNIHQEGNRLYIQNAREDDSGTYTCVCFTEDGLRYVSDFQLEVEENTISDV 3278

  Fly  1050 LP-DLARAETKEAP------------PPSHPASSLGGGPPTTSQT------PLGGTSGMLLVG-- 1093
            || ..:|.|..|..            |.::..|.:.|..|....|      .....||:.|.|  
Mosquito  3279 LPRSTSRMEFAERGTTVKLQCNTDLYPTTYQWSRIDGELPNDRDTHGVSVLKCRNESGITLTGDH 3343

  Fly  1094 VGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAELTEDSSNTPNLVIIGISLAAFGFLLVNA 1158
            :.:..::.|.||            :....|..:..|:....|:|    |:|        .|:|| 
Mosquito  3344 LCSQSILTLTNV------------QASDAGKYVCSAKHGGQSAN----VVI--------TLVVN- 3383

  Fly  1159 SLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYN-----DTVTGETLSSVSEKSES------ 1212
            :::.:|                       ..:|.||.     |.|..:....||.|.|.      
Mosquito  3384 NVIPFF-----------------------PQSPRSYMEFKSFDNVYSKFYFEVSFKPEKMNGLIL 3425

  Fly  1213 YSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQKDGTLPVIYPNNVVNA---CTLPHPR-HN 1273
            |:::.....:||        |..|..|  .|..|:..||...|:.|...|:.   .|:...| .|
Mosquito  3426 YASQRRPNQDYI--------SLSLRNG--YPQFRFNFDGQQVVLQPEKPVHMGQWHTVKVNRVRN 3480

  Fly  1274 NGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDG-SYYNMNSDRYL 1317
            ||...:    |||            :|...||. .:|.:|.|.:|
Mosquito  3481 NGFLLV----DDQ------------TPVNFPDRLKFYGLNLDDHL 3509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352 22/101 (22%)
Ig 76..155 CDD:299845 19/86 (22%)
IG_like 186..279 CDD:214653 21/94 (22%)
Ig 197..279 CDD:299845 20/83 (24%)
IG_like 296..376 CDD:214653 19/105 (18%)
Ig 300..361 CDD:299845 14/78 (18%)
Ig 380..454 CDD:299845 14/75 (19%)
IG_like 490..573 CDD:214653 25/91 (27%)
Ig 501..560 CDD:299845 16/67 (24%)
Ig 584..666 CDD:299845 22/86 (26%)
IG_like 585..666 CDD:214653 22/85 (26%)
I-set 678..767 CDD:254352 26/101 (26%)
IGc2 692..757 CDD:197706 19/67 (28%)
Ig 788..849 CDD:143165 18/60 (30%)
Ig 885..960 CDD:143165 18/78 (23%)
FN3 967..1051 CDD:238020 22/119 (18%)
AgaP_AGAP003656XP_313432.5 LDLa 9..43 CDD:238060
LDLa 53..83 CDD:238060
LDLa 95..130 CDD:238060
LDLa 132..167 CDD:238060
LDLa 174..209 CDD:238060
LDLa 263..297 CDD:238060
LDLa 322..354 CDD:197566
LDLa 364..398 CDD:238060
LDLa 409..441 CDD:197566
LDLa 505..538 CDD:238060
LDLa 541..575 CDD:238060
LDLa 633..667 CDD:238060
LDLa 684..717 CDD:238060
LDLa 721..754 CDD:238060
LDLa 757..792 CDD:238060
LDLa 795..829 CDD:238060
LDLa 831..865 CDD:238060
LDLa 896..931 CDD:238060
IG_like 956..1037 CDD:214653
Ig 956..1017 CDD:299845
LDLa 1079..1113 CDD:238060
LDLa 1119..1153 CDD:238060
LDLa 1162..1196 CDD:238060
IG_like 1206..1280 CDD:214653
Ig 1214..1289 CDD:299845
Laminin_B 1387..1505 CDD:278481
TNFRSF <1558..1640 CDD:304602
CRD2 1558..1599 CDD:276900
Laminin_B 1743..1870 CDD:278481
EGF_Lam 1916..1959 CDD:238012
Laminin_EGF 1977..2020 CDD:278482
Laminin_B 2088..2206 CDD:278481
Ig 2302..2375 CDD:299845 19/77 (25%)
IG 2309..2389 CDD:214652 19/91 (21%)
IGc2 2413..2470 CDD:197706 18/71 (25%)
IG 2503..2580 CDD:214652 14/82 (17%)
Ig 2503..2569 CDD:299845 14/71 (20%)
IG_like 2601..2677 CDD:214653 20/98 (20%)
Ig 2605..2675 CDD:299845 19/92 (21%)
ig 2689..2768 CDD:278476 24/91 (26%)
IG_like 2690..2770 CDD:214653 25/92 (27%)
Ig_2 2774..2863 CDD:290606 26/99 (26%)
IG_like 2781..2863 CDD:214653 22/89 (25%)
IG 2993..3069 CDD:214652 22/81 (27%)
IGc2 2998..3059 CDD:197706 20/66 (30%)
IG 3084..3153 CDD:214652 18/79 (23%)
Ig 3084..>3144 CDD:299845 16/70 (23%)
Ig_2 3185..3270 CDD:290606 15/90 (17%)
IG_like 3191..3270 CDD:214653 15/84 (18%)
IG_like 3289..3382 CDD:214653 20/116 (17%)
Ig 3295..3379 CDD:143165 18/107 (17%)
LamG 3395..3541 CDD:238058 36/141 (26%)
EGF_CA 3563..3597 CDD:238011
LamG 3643..3793 CDD:238058
EGF_CA 3848..3885 CDD:238011
Laminin_G_2 3924..4053 CDD:280389
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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