DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP004230

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_313139.4	Gene:	AgaP_AGAP004230 / 1274072	VectorBaseID:	AGAP004230	Length:	897	Species:	Anopheles gambiae

Alignment Length:	1164	Identity:	236/1164 - (20%)
Similarity:	396/1164 - (34%)	Gaps:	349/1164 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 GQTVELMCR---SRGGNPPAQLIWYK--NGSQIRMAYRTSGRL--SENIYTFTAEAGDNKARFRC 357
            |:|:.|.|.   ...|:....::||:  .||.|..| .|.||.  |...::..:..|| :|.|:.
Mosquito    16 GETIYLPCNVSTHEPGDNVVLVLWYREDKGSPIYSA-DTRGREVGSAKRWSDDSMFGD-RAYFQF 78

  Fly   358 EASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVR 422
            |          |...||:|  .....|..|....||..||                     .|.|
Mosquito    79 E----------KEPGELAV--QNVRETDSGMYRCRVDFIV---------------------AQTR 110

  Fly   423 NATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISG 487
            |              :..|:|.:|.|.:   :||...|.|:.|                  .::|
Mosquito   111 N--------------SVVNLTIIVPPER---MVIRDQLGMERT------------------TVAG 140

  Fly   488 -YMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAAD-------KSVSAEITI--L 542
             |.||..|      ||.|...||.|..|:|||:     :.|...||       |.:.:||.:  |
Mosquito   141 PYSEGDNI------KLRCDVYGGRPTPTVTWYR-----DGVAMVADTKYMPLGKHLRSEIALGPL 194

  Fly   543 ANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPP 607
            .. .|...:..|.|||.|...|:.||..:.::|||..:::....:.|..|....::|.|:.|.|.
Mosquito   195 TR-QDLHTKLVCRASNHARANPVEQSVQIDMNFAPLNIRLIGAHQPLSAGRRYDLLCQSAGSRPA 258

  Fly   608 AKLSWWKDGIPIE-GINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSA-HEAV 670
            |.::|:.||:.:: ....||..|  ..|.|||...:|.|..  |:..:|::.|..:|..| .:..
Mosquito   259 ASITWFLDGVRLDKSKETTSADG--NQTTSTLSIVLNRTDA--GKYLSCKAYNTYVQSDALEDGW 319

  Fly   671 SLDVLYRPKFVPPPSSTAVGV--------EGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHR 727
            .||:.|     .|.:|..:|.        ||..:......:|:|.....:|..:..|:.::....
Mosquito   320 QLDIQY-----VPDASVRLGSSLDPDAIREGTDVYFDCIVKAHPAVYKVEWKHNNKTLTRNISQG 379

  Fly   728 IFADGGSLNFTRLHRDDAGIYSCSASNSQG-GATLNITVVVEYGTTIKSVSENIV-VNPGEDAML 790
            :.....||....:.|..||.|:|...|::| |::....:.|.|..|.......:. |...|:|.:
Mosquito   380 VIVSKHSLVLQGVSRTTAGNYTCVGFNAEGEGSSPTFELNVMYAPTCAPNQPRVYGVAKQENAEI 444

  Fly   791 SCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNR 855
            .|.|:..| .:...||             ||.|....:.::.:....:|...
Mosquito   445 RCVVDANP-PDVEFKW-------------TFNNSAESIDVQASHISRLGTSS------------- 482

  Fly   856 DILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRTYKYEVEER 920
                ||.:.|.|
Mosquito   483 ----IVSYTPMI----------------------------------------------------- 490

  Fly   921 KIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEI--TSQPDPPLSLNILNVTHDTV 983
                             ..|||...|.|.|::|:..:.....|  ..:||...:..:.||:..::
Mosquito   491 -----------------ELDYGTLLCSATNKIGKQRQPCVFHIIAAGRPDQVHNCTVANVSMTSL 538

  Fly   984 TLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSS 1048
            .:....||:|||..|:.:..|.:..::.::.:..| ..:.|:..|..:.:|..:|.::|..|:|.
Mosquito   539 AVRCYEGFNGGLAQSFFLELRDSHSQEMRFNNTSP-VPRFTVPNLHPSAVYQLAVYAFNSKGRSE 602

  Fly  1049 YLPDLARAETKEAPPP--------SHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNV 1105
              |.:..|.|:..|..        ..|.|.|   |.|.:.:...|.:..:|:| ...||:.|
Mosquito   603 --PYVMSAATQRLPEKQMKDSEKVERPRSPL---PLTPTLSIAIGLAAAVLIG-SCAIVLAL--- 658

  Fly  1106 FVIGCCLHKRNEKRLKRGLELM-----PAELT---------EDSSNTPNLVIIGISLAAFGFLLV 1156
             ...|....|..|...:|..:.     |::.:         |.....|:::...|.
Mosquito   659 -KFPCGASGRRNKETAQGTTVRTSSPGPSDKSVASKEYDGNESDEKNPDVIPDTID--------- 713

  Fly  1157 NASLVAWFFVHQRRKKVAETTNQPAK---TATIEMYAPSSYNDTVTGETLSSVSEKSES----YS 1214
              |.....::.:|:......||.|::   |.|    ||   |.|..|.::::....:.|    |.
Mosquito   714 --SDDQMEYIKRRQHISTIDTNSPSRLLLTTT----AP---NQTFIGSSMAAALHANHSSTLGYC 769

  Fly  1215 NEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQKDGTLPVIYPNNVVNACTLP-HPRHNNGSAA 1278
            ...:..|:..:.:...:..                  .:|..:.......|||| ||
Mosquito   770 TLRNGTPQASNSITNVSMC------------------HMPSTFTTASHTTCTLPRHP-------- 808

  Fly  1279 IHMTRDDQMLISKGVYIPSPSPAPPPDGSYYNMNSDRYLSYPPMEYPAALDFTAQPMPMAHLQPM 1343
                      ::.|.....|.|..|        |:..:.||..              .:|.::.:
Mosquito   809 ----------VTAGTGAVGPGPLTP--------NAHHWPSYGG--------------TIAGVRNI 841

  Fly  1344 TVTSLATNGGPTLIGNGSVAAVAGGSGTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQM 1402
            |..|:.:|.|.......|..|:.....|.|   .|..:|:|:.:|:..|      |:.|
Mosquito   842 TAISVTSNQGSPAPPPPSAIAMQHLGPTAR---TRVCIGLPEDEVSADT------PLMM 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	23/82 (28%)
		Ig	300..361	CDD:299845	20/67 (30%)
		Ig	380..454	CDD:299845	13/73 (18%)
		IG_like	490..573	CDD:214653	29/91 (32%)
		Ig	501..560	CDD:299845	22/67 (33%)
		Ig	584..666	CDD:299845	23/82 (28%)
		IG_like	585..666	CDD:214653	23/81 (28%)
		I-set	678..767	CDD:254352	19/97 (20%)
		IGc2	692..757	CDD:197706	14/64 (22%)
		Ig	788..849	CDD:143165	10/60 (17%)
		Ig	885..960	CDD:143165	7/74 (9%)
		FN3	967..1051	CDD:238020	19/83 (23%)
AgaP_AGAP004230	XP_313139.4	Ig	11..118	CDD:299845	34/150 (23%)
		IG_like	11..102	CDD:214653	26/99 (26%)
		Ig	150..224	CDD:299845	25/79 (32%)
		Ig	246..307	CDD:299845	19/64 (30%)
		IG_like	248..311	CDD:214653	20/66 (30%)
		I-set	337..420	CDD:254352	16/82 (20%)
		IGc2	344..409	CDD:197706	14/64 (22%)
		Ig_3	440..503	CDD:290638	20/163 (12%)
		FN3	522..601	CDD:214495	18/79 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810