DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP003235

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_312941.4	Gene:	AgaP_AGAP003235 / 1273907	VectorBaseID:	AGAP003235	Length:	417	Species:	Anopheles gambiae

Alignment Length:	397	Identity:	104/397 - (26%)
Similarity:	153/397 - (38%)	Gaps:	81/397 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 VNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVL--YRPKFVPPPSSTAVGVEGESLQVSLQTRA 704
            |::..|..|   |.|:.:....|.|....|:..|  |:..::.....|.:.::|.     :.|..
Mosquito    15 VDLEPEFEG---TIQNISSPTGREAILTCSVKNLGRYKVGWLRASDQTVLALQGR-----VVTHN 71

  Fly   705 NPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSC----SASNSQGGATLNITV 765
            :...|.::            |.|.:    .|...:|...|.|.|.|    |....|.|.   |.|
Mosquito    72 SRISVVHE------------DFRTW----RLRIRQLRESDRGCYMCQINASPMKKQIGC---IDV 117

  Fly   766 VVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERV-GYDMTVKTSTT-------FA 822
            .|......:..|.:|.|..||||.:.|...|.|  ...|.|:|. |..|.::...:       ..
Mosquito   118 QVPPDIINEESSADIAVQEGEDATIVCKAVGHP--TPRVTWKREDGEYMLLRKPQSRELIRVEAY 180

  Fly   823 NGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLP 887
            ||| :||:...:|..:|.:.|:|.|.|....::.:.|.|.|||.:..|..||.|..|:..  :|.
Mosquito   181 NGT-HLHLPKLERRQMGAYLCIASNDVPPAVSKRVSLSVHFAPSVRPTSQLLGAPLGSDV--QLE 242

  Fly   888 CRAQGSPKPQFIWRQDKKDLP------INRTY---------------KYEVEERKIDSLTYESTL 931
            |..:.||.|...|.:..:.||      .|..|               ||.:.|.:....| ...|
Mosquito   243 CTVEASPMPVSYWLKGGRVLPNSFAGAANGNYEQPGLSRPEMLLDGPKYGITEDRHGFRT-NMRL 306

  Fly   932 IVDKVAPADYGAYECVARNELGEAVETVRL-EITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGL 995
            :|...:|||.|.|.||:.|.||.|..|:|| ||...|..      :..|.|.:.:.      |||
Mosquito   307 VVRSFSPADVGTYHCVSTNSLGRADGTMRLYEIKIHPGG------VQTTDDQLNII------GGL 359

  Fly   996 KASYRVR 1002
            ..:.|.|
Mosquito   360 AEAARGR 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845	6/23 (26%)
		IG_like	585..666	CDD:214653	6/23 (26%)
		I-set	678..767	CDD:254352	17/92 (18%)
		IGc2	692..757	CDD:197706	12/68 (18%)
		Ig	788..849	CDD:143165	19/68 (28%)
		Ig	885..960	CDD:143165	28/95 (29%)
		FN3	967..1051	CDD:238020	8/36 (22%)
AgaP_AGAP003235	XP_312941.4	Ig	26..109	CDD:299845	19/103 (18%)
		IG_like	33..119	CDD:214653	22/109 (20%)
		IG_like	129..218	CDD:214653	27/91 (30%)
		Ig	140..206	CDD:299845	19/68 (28%)
		IG_like	233..337	CDD:214653	31/106 (29%)
		IGc2	236..328	CDD:197706	25/94 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910