DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and AgaP_AGAP002336

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_312632.5	Gene:	AgaP_AGAP002336 / 1273631	VectorBaseID:	AGAP002336	Length:	901	Species:	Anopheles gambiae

Alignment Length:	1225	Identity:	217/1225 - (17%)
Similarity:	360/1225 - (29%)	Gaps:	469/1225 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 DIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHG 459
            |.|||:....|:.......|.||.........:.:|||..| |..|:.|..           |..
Mosquito     9 DTVPLSTKPMPTGRRKPSSWKVGVLVTLLLAMQLLVSPAHG-TEESDFTKQ-----------CSN 61

  Fly   460 LNMQLTENVVSTHTINVLYPPAPPLISGYME------GQI--IPA--------GSVQKLLCVSSG 508
            ..........|....|...|..|..:|..::      .||  :||        .::|||..
Mosquito    62 CKCSWKSGRKSADCTNQRLPVVPQELSNELQILDLSHNQIDELPAKTFEAAHQTNLQKLYL---- 122

  Fly   509 GNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSAT--EIPLFQSTTL 571
                          |.||:.| .|:.....:|||..:.        .|:|:.|  |..:|...|
Mosquito   123 --------------RHNSMKR-VDRDAFRNLTILIELD--------MANNNLTALEAGVFDDLT- 163

  Fly   572 SVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVS 636
                     |||:            ||.:::.               ||.|:.    .|:.|
Mosquito   164 ---------KIRV------------IILNNNQ---------------IERIDK----NLFYG--- 185

  Fly   637 TLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQ 701
             |::...|....|..|                .::|:     .||..|:.:.:.::...||...:
Mosquito   186 -LQYLTKVHLRSNRLV----------------RIALN-----SFVNVPNLSQIELDYNELQALRK 228

  Fly   702 TRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVV 766
            .                                 :|:.|.:    :.|.|.:|:....:..:...
Mosquito   229 E---------------------------------SFSGLEK----LTSLSLTNNPWNCSCTLRSF 256

  Fly   767 VEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIK 831
            .||     .:::|:..:|     .:|:|   |......:|..:..|
Mosquito   257 AEY-----VLAKNLYTSP-----TACSV---PKALAGRQWTEIELD------------------- 289

  Fly   832 DAKREDVGNFRC---VADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGS 893
                    :|.|   :.:||:..|                          |.||.....|:..|.
Mosquito   290 --------DFACPPAIVENRMQFP--------------------------GAGENATFICKVTGL 320

  Fly   894 PKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDK-----VAPADYGAYECVARNELG 953
            |.|:..|...|:... ....:..|.|....|...:|.::|.:     |.|:|.|.|.|.|.|..|
Mosquito   321 PLPKIDWLFQKRSFS-RHDQRLRVTEAVRTSPRDQSEVLVSELTIVGVRPSDRGTYVCKATNRGG 384

  Fly   954 EAVETVRLEITSQPDPPLS-----------LNILNVTHDTVTLAWTPGF-----------DGGLK 996
            ........::.:.|.|..|           |.::.|....|.|:|...:           :..::
Mosquito   385 IDESEQFFDLKADPHPITSATRSKDILQIVLIVVVVVLLFVILSWVLVYCICCRKRRFKKNSAMR 449

  Fly   997 ASYRVRYRMADREQYKYI-DGLPNSHKLTIGGLRMNTLYLFSVMSWNELGQSSYLPDLARAETKE 1060
            .:.::..:|.|:.|.:.| ||         |.:.::.             |.|.|.::   ...|
Mosquito   450 ENGQMNTKMMDKSQNESILDG---------GSVMVDM-------------QKSLLTEV---NPVE 489

  Fly  1061 APPPSHPASSLGGGPPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLE 1125
            .||......:...||.:..|:.:||...                        .|...||
Mosquito   490 KPPRRADIDAGEKGPGSGGQSSVGGDYD------------------------EKHEAKR------ 524

  Fly  1126 LMPAELTEDSSNTPNLVIIGISLAAFGFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYA 1190
                .|.|::                ||:..:          :....||.:.:.|...||   :.
Mosquito   525 ----TLLEET----------------GFVAQD----------EETASVALSDSNPRSRAT---FV 556

  Fly  1191 PSSYNDTVTGETLSSVSEKSESYSNEGSSQPEYIDEVRKKAASTYLVEGSDMPPPRYQK-DGT-- 1252
            .......:..:.|:..:...:|.|.:.|....:...:..|         |.:..|.||. .||
Mosquito   557 DDGCGTNLPPDLLAFPARFPQSPSIQSSMSNIHDGRIYGK---------SPLASPIYQTGPGTSL 612

  Fly  1253 -------LPVIYPNNVVNACTLPHPRHNNGSAAIHMTRDDQMLISKGVYIPSPSPAPPPDGSYYN 1310
                   :|..:.       ||.||: ...:.||...|      |...:.|:|...||     ..
Mosquito   613 GGGASAQMPAGFR-------TLQHPK-TGRTIAIAAAR------SNSPFTPAPLIYPP-----LA 658

  Fly  1311 MNSDRYLSYP-----PMEYPA-ALDFTAQPMP---MAHLQPMTVTS-LATNGGPTLIGNGSVAAV 1365
            :....|::.|     |...|: :...||:.:|   ..|....:.|| :..:.|..:..|..:...
Mosquito   659 LKHQGYVTIPRKQRTPSWTPSMSSAVTAELLPAGSAGHSGATSPTSPIDLSLGEPVYDNLGLRTT 723

  Fly  1366 AGGSGTLRRGILRGVVGVPQPDVTHHTSTVGGSPMQMLHDLHPVNLSASTLTTSTTLNGSLPTAT 1430
            |.|:.||:.. ..|:.|.|          :|.:             :|.|..|||.: .......
Mosquito   724 ASGNSTLKLN-KTGLRGTP----------LGST-------------AAGTALTSTPM-AKYSMKD 763

  Fly  1431 ATLPRQPHGILKDPNRNKQQQQQQQQQQQQQQLQHQQQLLNASLVGVG------VPVSAPLGSLQ 1489
            ..||..|.|....|                          |:||:|.|      :|.:.|.|:.|
Mosquito   764 RPLPATPGGQTATP--------------------------NSSLLGHGGGNYEAIPEALPYGAGQ 802

  Fly  1490 ILNLPPASGGLGNNLLMTTNAFDP---TTVGLSSFG-----------AVSQAGGI 1530
            .:    .:|||....|..::.:.|   ||...|...           .:..||||
Mosquito   803 SM----VAGGLSGFDLDQSSIYGPVVGTTTNRSKVPPRPPPKPKKKVVLPAAGGI 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845	15/58 (26%)
		IG_like	490..573	CDD:214653	21/100 (21%)
		Ig	501..560	CDD:299845	12/58 (21%)
		Ig	584..666	CDD:299845	11/81 (14%)
		IG_like	585..666	CDD:214653	11/80 (14%)
		I-set	678..767	CDD:254352	10/88 (11%)
		IGc2	692..757	CDD:197706	7/64 (11%)
		Ig	788..849	CDD:143165	8/63 (13%)
		Ig	885..960	CDD:143165	20/79 (25%)
		FN3	967..1051	CDD:238020	17/106 (16%)
AgaP_AGAP002336	XP_312632.5	LRR_RI	<88..263	CDD:238064	49/309 (16%)
		leucine-rich repeat	91..116	CDD:275380	4/24 (17%)
		LRR_8	115..175	CDD:290566	22/123 (18%)
		leucine-rich repeat	117..140	CDD:275380	8/41 (20%)
		leucine-rich repeat	141..164	CDD:275380	7/40 (18%)
		leucine-rich repeat	165..188	CDD:275380	10/57 (18%)
		LRR_8	189..246	CDD:290566	14/114 (12%)
		leucine-rich repeat	189..212	CDD:275380	6/43 (14%)
		leucine-rich repeat	213..236	CDD:275380	4/55 (7%)
		TPKR_C2	245..294	CDD:301599	10/88 (11%)
		Ig	295..394	CDD:299845	26/125 (21%)
		IG_like	307..389	CDD:214653	22/82 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910