DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP000720

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_003437079.1	Gene:	AgaP_AGAP000720 / 1272313	VectorBaseID:	AGAP000720	Length:	1271	Species:	Anopheles gambiae

Alignment Length:	847	Identity:	184/847 - (21%)
Similarity:	302/847 - (35%)	Gaps:	204/847 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 PPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIR-MAY--RTSGRLSENIYT 343
            ||.....:....||:   .:...:.|.:. |.|..:..|.|||.:.. ..|  |.|.:.......
Mosquito    46 PPDEMLFQVAQQGES---DKPFLIECEAE-GEPTPKYRWIKNGKKFEWQTYDDRMSQQPGRGTLV 106

  Fly   344 FTAEAGDNKARFRCEASN----VMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTA 404
            .|:...::..:::|.|.|    ..|.:....:.||:.....:..|:    :|..|....|.|...
Mosquito   107 ITSPRDEDLGQYQCFAENEHGTATSNSVFVRKAELNSFKDGSPQTL----QADEGKPFKLVCQPP 167

  Fly   405 PSNPPAEIKWMV----GG-RQVRNATSKTIVSPEGG-WTTTSNITAVVEPNK-----------RS 452
            ...|...:.||:    || |.:.|  |:..:.|||. |  .||:|...|.|.           ||
Mosquito   168 DGWPKPNVYWMIQNMDGGIRSINN--SRMTLDPEGNLW--FSNVTRDDESNDFFYACAASSVFRS 228

  Fly   453 LVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTW 517
            ...|.:.:.:|:.:..:|  .....:||....:|  .:.::...|...:|.|: .||.||....|
Mosquito   229 EYKIGNRVLLQVKQTGIS--AAQNRHPPQRQYVS--RKNEVALKGKQIELFCI-YGGTPLPETVW 288

  Fly   518 YKNDKRI--NSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETV 580
            .||.:.|  |..|:..:...|.:|..::  |::...|.||.||...:...: |..|:|:..|
Mosquito   289 TKNGRAIVWNDKIQQDNYGKSLKIRRVS--SEDAGTYTCEVSNGVGQADSY-SINLAVNAVP--- 347

  Fly   581 KIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVT 645
            ...:|||                                  |.|.:
Mosquito   348 YFTVEPE----------------------------------IVNAA------------------- 359

  Fly   646 QEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVT 710
                                                          |||:.:...:...||.| .
Mosquito   360 ----------------------------------------------EGETAEFKCEAAGNPKP-N 377

  Fly   711 YKWTKDGTTIP-QDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIK 774
            ..|..:|..|. ..|:.|......|:..::|.:.|.|.|.|:|:||             .|...|
Mosquito   378 IMWIHNGKQIDVSQGNARRIVGSSSIYISKLQKSDTGNYGCNATNS-------------LGYVYK 429

  Fly   775 SVSENI------VVNPGE--------DAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGT 825
            .|..|:      :.:|.:        :..::|.|.|.|  :..|||.|...::|.....|..:|.
Mosquito   430 DVYLNVLALAPEITDPPKREFTVDQRNVTMTCRVFGAP--KPQVKWLRNDRELTGGRYQTMPSGD 492

  Fly   826 SYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRA 890
              |.|:|.|.:|.|.:.|.|.|.:.:.:... .||||....|...|....|.:||....|....|
Mosquito   493 --LFIRDVKFDDAGEYTCHAVNNLGSKSASG-ELIVKERTVINDPPQDYEAEAGTTVTFRCNAIA 554

  Fly   891 QGSPKPQFIWRQDKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEA 955
            ..|.:....|      |.......:|.:.|.|  .|.:::|::.|....|.|.|.|:||.:|.|.
Mosquito   555 DSSLELTIEW------LTKGEIIDFENQPRFI--RTSDNSLMISKTIELDTGTYTCLARTDLDEV 611

  Fly   956 VETVRLEITSQPDPPLSLNILNVTHDTVTLAWTPGFDGGLK-ASYRVRYRMA-DREQYKYI-DGL 1017
            :....|.:..:|:|| :|..:|.......:.|....|.... .:|.:.|..: ..:.|..: |.:
Mosquito   612 MANATLTVMDRPNPP-TLTRVNCKGKVAQIEWISNGDNRSPILNYIIEYNTSFTPDTYDVLSDDV 675

  Fly  1018 PNS-HKLTIGGLRMNTLYLFSVMSWNELGQSSYLP----DLARAETKEAPPPSHPASSLGGGPPT 1077
            |.: ...|:.....|. |.|.|::.|::|:|  ||    |:  ..|:.:.|..:|.:..|.|...
Mosquito   676 PGTDFAWTVNTTPWNN-YTFRVIAVNKVGRS--LPSGHSDV--CTTESSVPYKNPDNLEGEGTTP 735

  Fly  1078 TS 1079
            |:
Mosquito   736 TN 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	17/86 (20%)
		Ig	300..361	CDD:299845	13/63 (21%)
		Ig	380..454	CDD:299845	24/90 (27%)
		IG_like	490..573	CDD:214653	23/84 (27%)
		Ig	501..560	CDD:299845	20/60 (33%)
		Ig	584..666	CDD:299845	5/81 (6%)
		IG_like	585..666	CDD:214653	5/80 (6%)
		I-set	678..767	CDD:254352	20/89 (22%)
		IGc2	692..757	CDD:197706	20/65 (31%)
		Ig	788..849	CDD:143165	20/60 (33%)
		Ig	885..960	CDD:143165	19/74 (26%)
		FN3	967..1051	CDD:238020	20/87 (23%)
AgaP_AGAP000720	XP_003437079.1	I-set	39..131	CDD:254352	18/88 (20%)
		Ig	64..137	CDD:299845	15/73 (21%)
		Ig	152..222	CDD:299845	21/77 (27%)
		I-set	262..343	CDD:254352	23/84 (27%)
		Ig	272..336	CDD:299845	20/66 (30%)
		I-set	347..435	CDD:254352	29/203 (14%)
		Ig	361..436	CDD:299845	23/88 (26%)
		I-set	440..525	CDD:254352	22/89 (25%)
		IGc2	455..515	CDD:197706	20/63 (32%)
		IG_like	535..619	CDD:214653	24/91 (26%)
		Ig	546..623	CDD:299845	20/84 (24%)
		FN3	623..715	CDD:238020	23/97 (24%)
		FN3	724..812	CDD:238020	4/14 (29%)
		fn3	825..913	CDD:278470
		FN3	925..1012	CDD:238020
		fn3	<1052..1111	CDD:278470
		Bravo_FIGEY	1162..1242	CDD:290593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910