DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP000217

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_310917.4	Gene:	AgaP_AGAP000217 / 1272050	VectorBaseID:	AGAP000217	Length:	856	Species:	Anopheles gambiae

Alignment Length:	951	Identity:	221/951 - (23%)
Similarity:	347/951 - (36%)	Gaps:	253/951 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQ 131
            |...:|:|...|.|...:.|:...:.|.|.|.:|.:|||||.|.||....:.||.||:::|..::
Mosquito    48 SRQLEQRFAMEPQDQTAIVGSRVTLPCRVVNKSGQLQWTKDDFGLGTHRNLSGFERYTMVGSDEE 112

  Fly   132 GIYNLRISNASINDDADYQCQVGPARLNS-AIRAN-AKLTVISPPASIEIKGYSHNSKVEVRENQ 194
            |.::|.||...::|||.|||||||.|..: .||:. |||.|:.||.:.:|   .....:...|::
Mosquito   113 GDFSLDISPVMLDDDAKYQCQVGPGRGGTPGIRSRFAKLIVLVPPEAPKI---VQGDFMVTTEDR 174

  Fly   195 DLQLKCIVANAKPAAQIVWYRG-------NVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDD 252
            :::|:|:....||||:|.|..|       .:||..|...|      |:|:|..|.|||.|..:..
Mosquito   175 EIELECVSVGGKPAAEITWIDGLGTVLTRGIEYMKEPLRD------ARRYTAKSILKLTPKKEHH 233

  Fly   253 YTEYTCQARHKALSPDMPMRAT-VQLSVLYPPGP--PYIEGYSAGETLRRGQTVELMCRSRGGNP 314
            .|.:||||::.|   |...|:. ::|.|.|.|..  ..|.|...|..:..|..|.|.||:....|
Mosquito   234 NTTFTCQAQNTA---DRTYRSVRLKLEVKYAPKVKIAVIGGALNGGRILEGTEVRLSCRADANPP 295

  Fly   315 PAQLIWYKNGSQIRMAYRTSGRLSENI---YTFTAEAGDNKARFRCEASNVMSQNPLKAEVELSV 376
            .....|:. |.::......|..|..||   |..|.        .|||..|.:.::  :..|.|.:
Mosquito   296 DVTYRWFV-GEELSDGSHASELLIANISRKYHGTT--------VRCEVRNAVGKS--EESVTLDI 349

  Fly   377 LFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSKTIVSPEGGWTTTSN 441
            .:.|:........||.....|.|.| ....||..::.|:       :..|..:||      :.:|
Mosquito   350 SYGPSFRAPPQSVEADPDTTVTLGC-DVDGNPAPDVLWI-------HEPSDQVVS------SAAN 400

  Fly   442 ITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQ---KLL 503
            :|.||.|..... ..|.. ::|....|.:..|:   |...||.||...:    ..|:|.   :|.
Mosquito   401 VTLVVTPATAGR-YYCKA-SVQGFAEVEADATV---YLRGPPAISSPRQ----QYGAVHDSAQLE 456

  Fly   504 CVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQS 568
            ||:........:.|..|.:.||         ||||        .|.|:||...|    .||....
Mosquito   457 CVALSIPKPRHVLWSFNGREIN---------VSAE--------PNAAEYRALDS----PIPNGVR 500

  Fly   569 TTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWG- 632
            :||.:|..         ..|.......|::.|           :..|.:.||.::. .||.|..
Mosquito   501 STLIIHHC---------QREHFGRYNCTVVND-----------YGIDYLEIEFVSK-GKPNLLPV 544

  Fly   633 ------GTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGV 691
                  |.::.|...|.:.      :..|...|                 |.|.:||
Mosquito   545 IVLGSLGGITILIILVVIA------ICLCSRRN-----------------RKKHLPP-------- 578

  Fly   692 EGESLQVSLQTRANPTPVT-----YKWTKD---------------------GTTIPQDGDHRIFA 730
              ..:...::.||| :||.     ::::.|                     |.:....|:.....
Mosquito   579 --ADVIPKVRVRAN-SPVACGSVQFRYSGDFSDSLSHLQCPKVGGGPTGTSGNSTSSTGNSTSNN 640

  Fly   731 DGGSLNFTRLHRDDAGIYS-----------CSASNSQGGA------------------TLNIT-- 764
            ..|.:.:....||    ||           .|:|||.|.|                  |:.:|
Mosquito   641 SNGYVPYVNYARD----YSPPTQHLMQFKASSSSNSIGNALTAKPPARPPANGQLPTGTMTLTRK 701

  Fly   765 -----------VVVEYGTTIKSVSENIVVNPGE-----DAMLSCTVEGKP--LTEEHVKWERVGY 811
                       .:....:::.|:...::.||.:     .|..:.|....|  .|........:|.
Mosquito   702 RTPAAPPDAGGALPSIQSSVSSIPNGLMSNPMQLPPPATANPAATPAPPPYSATRNQNCLLGLGL 766

  Fly   812 DMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRA 876
            .......||..|..:.|....:                 :|::.....:...:.::::.|::...
Mosquito   767 PPAAGGPTTGTNSAALLATGSS-----------------SPSSTQSGSLSLASSQLSQAPSIAGG 814

  Fly   877 ASGTGE--RGRLPCRAQ-GSPKPQFIWRQDKKDLPINRTYK 914
            ..|||:  .||...:.| .||..|||       ||.:.|.|
Mosquito   815 TVGTGQGAGGREQQQQQPNSPPGQFI-------LPSSNTIK 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	41/98 (42%)
		Ig	76..155	CDD:299845	32/78 (41%)
		IG_like	186..279	CDD:214653	31/100 (31%)
		Ig	197..279	CDD:299845	30/89 (34%)
		IG_like	296..376	CDD:214653	20/82 (24%)
		Ig	300..361	CDD:299845	17/63 (27%)
		Ig	380..454	CDD:299845	17/73 (23%)
		IG_like	490..573	CDD:214653	22/85 (26%)
		Ig	501..560	CDD:299845	16/58 (28%)
		Ig	584..666	CDD:299845	14/88 (16%)
		IG_like	585..666	CDD:214653	14/87 (16%)
		I-set	678..767	CDD:254352	24/156 (15%)
		IGc2	692..757	CDD:197706	17/101 (17%)
		Ig	788..849	CDD:143165	9/62 (15%)
		Ig	885..960	CDD:143165	11/31 (35%)
		FN3	967..1051	CDD:238020
AgaP_AGAP000217	XP_310917.4	Ig	58..136	CDD:299845	32/77 (42%)
		IG_like	59..153	CDD:214653	40/93 (43%)
		C2-set_2	160..250	CDD:285423	30/101 (30%)
		Ig_3	280..336	CDD:290638	17/64 (27%)
		I-set	353..431	CDD:254352	20/93 (22%)
		IGc2	366..418	CDD:197706	15/67 (22%)
		Ig	435..531	CDD:299845	31/140 (22%)
		IG_like	442..525	CDD:214653	26/127 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920