DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP000522

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_310568.5	Gene:	AgaP_AGAP000522 / 1271719	VectorBaseID:	AGAP000522	Length:	340	Species:	Anopheles gambiae

Alignment Length:	471	Identity:	95/471 - (20%)
Similarity:	150/471 - (31%)	Gaps:	187/471 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 TENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLC-VSSGGNPLATLTWYK--------N 520
            :.:|:...::::..|.|            :..|:...|:| .....:.|.::.|||        .
Mosquito     1 SHSVLGLESVHIQVPVA------------VLVGTSATLICECDLPDDELYSVKWYKGKHEFFRYT 53

  Fly   521 DKRINS--VIRAADKSVSAEIT-----ILANVS-DNQAQYRCEASNSATEIPLFQ----STTLSV 573
            .|.|.|  :...|..||:..::     :|.||. .:..:|.||.:.:|   |.|.    :.|::|
Mosquito    54 SKEIPSIKIFPKAGISVNVNLSNASHLVLVNVEPQSSGKYSCEITEAA---PSFHTKIATRTMNV 115

  Fly   574 HFAPETVKIRIEPE--ELRP--GME--ATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWG 632
            ...|.|.     |:  :::|  |.|  ..:.|.|..|.|..||.|:.:.:|:    :...|
Mosquito   116 VDLPATA-----PQILDIKPFYGAEEFLEVECRSGPSLPAPKLEWFVNDLPL----HQPLP---- 167

  Fly   633 GTVSTLEFRVN-------VTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVG 690
             ..|.||:...       .|...:|   :..|::...::||..::       |....|||:
Mosquito   168 -VPSRLEYGTQPGSADRPTTASSSG---SSSSSSSRKKQSAKSSL-------PAPTVPPST---- 217

  Fly   691 VEGESLQVSLQ--TRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSAS 753
             :|||.:..|.  ....|.|..      |||           :||                   |
Mosquito   218 -DGESRENDLAEVLPGRPRPAI------GTT-----------NGG-------------------S 245

  Fly   754 NSQGGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTS 818
            :|....|..||.     ||..|.|.:....|.
Mosquito   246 SSSSSTTTTITT-----TTTSSSSSSSSQEPA--------------------------------- 272

  Fly   819 TTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDILLIVKFAPEIAKTPTLLRAASGTGER 883
               .||||..|     |:..||.|.                      |:|.:...|....|....
Mosquito   273 ---GNGTSGEH-----RKGAGNSRY----------------------ELAVSRLKLLLEHGHFRN 307

  Fly   884 GRLPCRAQGS---PKP 896
            |:|..||:.|   |.|
Mosquito   308 GKLKVRAEASLFCPPP 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	23/103 (22%)
		Ig	501..560	CDD:299845	18/75 (24%)
		Ig	584..666	CDD:299845	19/94 (20%)
		IG_like	585..666	CDD:214653	19/93 (20%)
		I-set	678..767	CDD:254352	20/90 (22%)
		IGc2	692..757	CDD:197706	13/66 (20%)
		Ig	788..849	CDD:143165	9/60 (15%)
		Ig	885..960	CDD:143165	6/15 (40%)
		FN3	967..1051	CDD:238020
AgaP_AGAP000522	XP_310568.5	IG_like	15..98	CDD:214653	21/94 (22%)
AgaP_AGAP000522	XP_310568.5	Ig	29..108	CDD:143165	19/81 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910