Protein Alignment sns and HPX4

DIOPT Version :9

• Sequence 1: NP_001036532.1
• Gene: sns / 44097
• FlyBaseID: FBgn0024189
• Length: 1542
• Species: Drosophila melanogaster
• Sequence 2: XP_308561.4
• Gene: HPX4 / 1269907
• VectorBaseID: AGAP007237
• Length: 1514
• Species: Anopheles gambiae
• Alignment Length: 914
• Identity: 198/914 - (21%)
• Similarity: 339/914 - (37%)
• Gaps: 203/914 - (22%)

  Fly   484 LISGYMEG---QIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANV 545
            |.|.|:.|   :.||.||.::|..:..                    :|..|.::..:.::|..|
Mosquito   140 LHSIYLHGNQIKTIPEGSFERLPSLRR--------------------LRLDDNALECDCSLLWFV 184

  Fly   546 SDNQAQYR--------CEASNSATEIPLFQSTTLSVHFA-PETVKIRIEPE--ELRPGMEATIIC 599
            ...|...|        |....:....|:...|....|.| ||.|   ::|.  |:..|..|...|
Mosquito   185 RTMQQPNRKSLVAGATCATPPALEGQPISSITEEDFHCAKPEIV---VQPRDIEISYGQTAVFSC 246

  Fly   600 DSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTL---EFRVNVTQEMNGQVYTC---QSA 658
             .:|.:|..::.|.::|.||...::        |.::.|   ..|::.....:...|.|   .|.
Mosquito   247 -KASGDPRPEIVWLQEGSPIRSESD--------GRITLLPDGSLRIDEIVPADAGQYACIARNSL 302

  Fly   659 NEALQRSAHEAVSLDVL----YRPKFVPPPSSTAVGVEGESLQVSLQTRANPTP-VTYKWTKDGT 718
            .|:..|:|..||:.:|:    ..|||:..|:.....:|||.:.:.......||| :.:|:..:..
Mosquito   303 GESRSRTASLAVNNEVVESEAEAPKFLRTPADPLELLEGEPIVLDCVVTGAPTPSILWKFNNENI 367

  Fly   719 TIPQDGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVN 783
               |:|..::|.: |||.......||.|||:|.|.|:.|..::|:||:|.....|....||..|.
Mosquito   368 ---QNGRIKLFGN-GSLILPTSTLDDGGIYTCCAGNALGNISVNVTVLVNAPPRIVLGPENQNVK 428

  Fly   784 PGEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNR 848
            .|....|.|..:|.||  .|:.|::.|..:...:...|.:....|.|..|:..|.|.:.|||:|.
Mosquito   429 VGSTLTLECEADGNPL--PHIWWKKDGLPVNETSQVYFTDDAIELTIDHAEESDSGTYVCVAENE 491

  Fly   849 VD-NPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRT 912
            :. .....::::|....|.....|..|.|..||  ...:||:|:.....|..|:::.:.:.....
Mosquito   492 LGIAEVEAEVVVINVGPPRFLFEPYDLDAIEGT--TVEMPCKAENDDILQIKWQKEGRTITPKDK 554

  Fly   913 YKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILN 977
            |:          ::...:|.:..:...|.|.|||...|:.|.|..:..|.:..:.:
Mosquito   555 YR----------ISSAGSLFIANITLTDEGRYECSLLNKYGRATASGMLTVKKKAE--------- 600

  Fly   978 VTHDTVTLAWTPGFDGGLKASYRVRYRMADREQYKYIDGLPNSHKLTIGGL----RMNTLY---L 1035
                            .|.....||..:|  |..:.:|...|.   |||.:    |..|.|   |
Mosquito   601 ----------------ALPGDQYVRIAIA--EASREVDMAINQ---TIGRMFSTGRNTTRYHDDL 644

  Fly  1036 FSVMSW-----NELGQSSYLPDLARAETKEAPPPSHPASSLGGGPPTTSQT-----PLGGTSGML 1090
            |.::.:     .|:.:::.:.:.|....::     |..|   |...||:.|     .|.....:.
Mosquito   645 FRIVRFPTGPAREIARAAEVYERALVIIRK-----HVES---GANLTTNTTDFWYQDLLSPEYLD 701

  Fly  1091 LVGVGAGIVVVLLNVFVIGCCLHKR---------NEKRLKRG------LELMPAELTEDSSNTPN 1140
            |:...:|.:...:.......|.|.:         |.|....|      ..|:| .:.|:..|:|
Mosquito   702 LLEQLSGCMAHRVTPNCSDLCFHSKYRSLDGTCNNYKHPAWGSSLTGFQRLLP-PVYENGFNSP- 764

  Fly  1141 LVIIGISLAAF--GFLLVNASLVAWFFVHQRRKKVAETTNQPAKTATIEMYAPSSYNDTVTGETL 1203
               ||.:.:|.  |:...:|.||:       ...::.:|..|....|..:.....:.|......:
Mosquito   765 ---IGWNRSAVYNGYRKPSARLVS-------TSLISTSTITPDDRITHMVMQWGQFLDHDLDHAI 819

  Fly  1204 SSVSEKSESYSNEGSSQP-EYIDEVRKKAASTYLVEGSDMPP--PRYQKDGTLPVIYPNNVVNA- 1264
            .||:  |||:......:. ||       ||..|.:   |:||  ||.|....:..:..:.|..:
Mosquito   820 PSVT--SESWDGVDCKKTCEY-------AAPCYPI---DIPPGDPRIQNRRCIDFVRSSAVCGSG 872

  Fly  1265 -------CTLPHPRHNNGSAAIHMTR----------------DDQMLISKGVYIPSPSP----AP 1302
                   ...|..:.|..:|.|..::                .:|.|:..|.:.|...|    :.
Mosquito   873 MTSIFFGSVQPREQINQLTAFIDASQVYGYTETFAQELRNLTTEQGLLRDGPHFPQQKPLLPFSA 937

  Fly  1303 PPDG 1306
            |.||
Mosquito   938 PTDG 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	15/93 (16%)
		Ig	501..560	CDD:299845	8/66 (12%)
		Ig	584..666	CDD:299845	19/89 (21%)
		IG_like	585..666	CDD:214653	19/88 (22%)
		I-set	678..767	CDD:254352	29/89 (33%)
		IGc2	692..757	CDD:197706	21/65 (32%)
		Ig	788..849	CDD:143165	18/60 (30%)
		Ig	885..960	CDD:143165	15/74 (20%)
		FN3	967..1051	CDD:238020	16/95 (17%)
HPX4	XP_308561.4	leucine-rich repeat	49..67	CDD:275380
		leucine-rich repeat	68..91	CDD:275378
		LRR_4	90..129	CDD:289563
		LRR_8	91..150	CDD:290566	4/9 (44%)
		leucine-rich repeat	92..115	CDD:275378
		LRR_4	114..155	CDD:289563	5/14 (36%)
		leucine-rich repeat	116..139	CDD:275378
		LRRCT	172..>210	CDD:214507	5/37 (14%)
		Ig	225..314	CDD:299845	23/100 (23%)
		I-set	225..314	CDD:254352	23/100 (23%)
		I-set	326..412	CDD:254352	29/89 (33%)
		IGc2	340..402	CDD:197706	21/65 (32%)
		I-set	416..503	CDD:254352	23/88 (26%)
		IGc2	430..493	CDD:197706	19/64 (30%)
		I-set	509..595	CDD:254352	22/97 (23%)
		Ig	526..594	CDD:299845	15/77 (19%)
		An_peroxidase	727..1266	CDD:281139	48/239 (20%)
		peroxidasin_like	848..1287	CDD:188658	18/94 (19%)
		VWC	1438..1496	CDD:278520

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910