DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and AgaP_AGAP002135

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_308060.4	Gene:	AgaP_AGAP002135 / 1269423	VectorBaseID:	AGAP002135	Length:	540	Species:	Anopheles gambiae

Alignment Length:	408	Identity:	81/408 - (19%)
Similarity:	133/408 - (32%)	Gaps:	132/408 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 SSGGNPLATLTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTT 570
            |..|.|...||...:....:....::..|:|:..::.::.|.:.|. ...:|:|::.|....|::
Mosquito    27 SQAGQPGNLLTGSSSSSSGSGSSSSSSSSISSSSSVSSSTSTSSAG-SSGSSSSSSSISTTSSSS 90

  Fly   571 LSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTV 635
            .|                   |..||:...||||:.|.            .:..|::|
Mosquito    91 SS-------------------GSAATVGASSSSSSRPT------------NVETTAQP------- 117

  Fly   636 STLEFRV----------NVTQEMNGQVY-TCQ---SANEALQRSAHEAVSLDVLYRPKFVPPPSS 686
             |.:.||          |||..:....| .|:   ..|:.:....|..:.|..:.|..:......
Mosquito   118 -TEQSRVGPYFDVAASKNVTALLGKTAYLNCRVKNLGNKTVSWVRHRDIHLLTVGRYTYTSDQRF 181

  Fly   687 TAV---GVEGESLQVS----------------------------LQTRANPTPVTYKWTKDGTTI 720
            .|:   ..|..|||:.                            :....:||.....|.|  ..:
Mosquito   182 RAIHHPHTEDWSLQIKYPQHRDSGIYECQISTTPHMSHFVHLNVIGKHRSPTAQPSSWVK--LAL 244

  Fly   721 PQDGDHRI--FADGGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTIKSVSENIVVN 783
            |......|  .||.....|.  |:......|..:|....||.   .:.:|.|:||.
Mosquito   245 PSTRSPEIARVADDACHKFQ--HKFQLVTSSAKSSARIIGAP---DLYIESGSTIN--------- 295

  Fly   784 PGEDAMLSCTVEGKPLTEEHVKWER----VGYD--------MTVKTSTTFANGTSYLHIKDAKRE 836
                  |:|.|:..|....::.|..    :.||        :|.|..||    ||:|.|::|:..
Mosquito   296 ------LTCVVKDSPEPPAYIFWNHNNAIISYDSPRGGVSVITEKGDTT----TSFLLIQNARPS 350

  Fly   837 DVGNFRCVADNRVDNPTN 854
            |.|.:.|       ||:|
Mosquito   351 DSGQYTC-------NPSN 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	13/66 (20%)
		Ig	501..560	CDD:299845	10/53 (19%)
		Ig	584..666	CDD:299845	19/95 (20%)
		IG_like	585..666	CDD:214653	19/94 (20%)
		I-set	678..767	CDD:254352	19/121 (16%)
		IGc2	692..757	CDD:197706	16/94 (17%)
		Ig	788..849	CDD:143165	19/72 (26%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
AgaP_AGAP002135	XP_308060.4	Ig	132..225	CDD:299845	14/92 (15%)
		IG_like	132..225	CDD:214653	14/92 (15%)
		IG_like	284..371	CDD:214653	26/107 (24%)
		IGc2	290..364	CDD:197706	25/98 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910