Protein Alignment sns and HHLA2

DIOPT Version :9

• Sequence 1: NP_001036532.1
• Gene: sns / 44097
• FlyBaseID: FBgn0024189
• Length: 1542
• Species: Drosophila melanogaster
• Sequence 2: XP_011510664.1
• Gene: HHLA2 / 11148
• HGNCID: 4905
• Length: 425
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 93/443 - (20%)
• Similarity: 147/443 - (33%)
• Gaps: 139/443 - (31%)

  Fly   751 SASNSQGGATLNITVVVEYGTTIKSVSENIVVNP-GEDAMLSCTVEGKPLTEEHVKWE---RV-- 809
            |.|.|||...|...:.|       .::|.||:.. .||.:|..:.|.......|.|::   :|
Human    16 SLSGSQGIFPLAFFIYV-------PMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDSYKVHS 73

  Fly   810 ---GYDMTVKTSTTFANGTS--YLHIKDAKRE---------DVGNFRCVADNRVDNPTNRDILLI 860
               |.|........:||.||  |..|::....         |.|.:.|.....:...||:.:|.:
Human    74 YYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCYVGTAIQVITNKVVLKV 138

  Fly   861 VKFAPEIAKTPTLLRAASGTGERGRLPCRAQG-SPKPQFIWRQDKKDLPINRTYKYEVEER-KID 923
            ..|.     ||.:......|  ...|.|.... .|:|...|:.|  :.||:..   .:||. .:|
Human   139 GVFL-----TPVMKYEKRNT--NSFLICSVLSVYPRPIITWKMD--NTPISEN---NMEETGSLD 191

  Fly   924 SLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLEITSQPDPPLSLNILNVTHDTVTLAWT 988
            |.:..|.|.:    .....:|||...|.|.:...|.|..:..      .|:.:...|  |:|:..
Human   192 SFSINSPLNI----TGSNSSYECTIENSLLKQTWTGRWTMKD------GLHKMQSEH--VSLSCQ 244

  Fly   989 PGFDGGLKASYRVRYRMADREQYKYIDGLPN-SHKLTIGGLRMNTLYLFSVM------------- 1039
            |..|                    |..  || ..|:|...::..|   |||:
Human   245 PVND--------------------YFS--PNQDFKVTWSRMKSGT---FSVLAYYLSSSQNTIIN 284

  Fly  1040 ----SWNE--LGQSSY---LPDLARAETKE------------------APPPSHPASSLGGGPPT 1077
                |||:  :.||.:   |.||..:::.|                  ...||...:|...|
Human   285 ESRFSWNKELINQSDFSMNLMDLNLSDSGEYLCNISSDEYTLLTIHTVHVEPSQETASHNKG--- 346

  Fly  1078 TSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKRNEKRLKRGLELMPAE 1130
                        |.:.|.:.|:...|.::.:.||..:...:|.:.     ||:
Human   347 ------------LWILVPSAILAAFLLIWSVKCCRAQLEARRSRH-----PAD 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352	6/15 (40%)
		IGc2	692..757	CDD:197706	3/5 (60%)
		Ig	788..849	CDD:143165	16/79 (20%)
		Ig	885..960	CDD:143165	20/76 (26%)
		FN3	967..1051	CDD:238020	20/106 (19%)
HHLA2	XP_011510664.1	Ig	47..125	CDD:325142	16/77 (21%)
		Ig	137..215	CDD:325142	21/93 (23%)
		V-set	231..330	CDD:311561	24/125 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910