DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and LOC110439986

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_021333824.1	Gene:	LOC110439986 / 110439986	-ID:	-	Length:	358	Species:	Danio rerio

Alignment Length:	402	Identity:	101/402 - (25%)
Similarity:	176/402 - (43%)	Gaps:	62/402 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   466 ENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRA 530
            :.|:|.| ::....|..|:|| .....:|..|....|.|.|:...|....:|:|.:..:.|
Zfish     6 DRVLSLH-VSPADAPDTPVIS-INRSAVIKEGDSVTLNCSSNANPPALNFSWFKGETFVGS---- 64

  Fly   531 ADKSVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEE-LRPGME 594
                 |....|....||:..:|:|:|.|...| ......||.|.:.|..:.:.:.... :..|..
Zfish    65 -----SRIFNISKISSDDNKKYKCKAKNDLGE-KYSDPVTLDVQYPPRNISVSMNRSAVIMSGDS 123

  Fly   595 ATIICDSSSSNPPAKLSWWKDGIPIEG--INNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQS 657
            .|:.| ||.|||||::||:|....:..  |.|.||                ::.:.:|: |.|::
Zfish   124 VTLSC-SSDSNPPAEISWYKGETSVGSGRIFNISK----------------ISSDDSGE-YKCRA 170

  Fly   658 ANEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQ 722
            .|:..::.: :.|:|||.|.|......:.:||.:||:|:.::..:.:|| |..:.|.|...::
Zfish   171 RNDHGEKYS-DPVTLDVQYAPDTPVISNRSAVIMEGDSVTLNCSSNSNP-PANFSWFKGNKSL-- 231

  Fly   723 DGDHRIFADGGSLNFTRLHRDDAGIYSCSASNSQGGATLN-ITVVVEYGTTIKSVSEN--IVVNP 784
             ...|||      :.:::..||:|.|.|.|.|..|....: :|:.|:|.....|||.|  .|:..
Zfish   232 -NSGRIF------SISKISSDDSGEYKCRARNVHGEKYSDPVTLDVQYPPRNISVSMNRSAVIMS 289

  Fly   785 GEDAMLSCTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRC----VA 845
            |:...|||:.:..|..|  :.|        .|..|:..:|..: :|.....:|.|.::|    :.
Zfish   290 GDSVTLSCSSDSNPPAE--INW--------FKGETSVRSGRIF-NISKISSDDSGEYKCRYKNIH 343

  Fly   846 DNRVDNPTNRDI 857
            ..:..:|...|:
Zfish   344 GEKYSDPVTLDV 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	20/82 (24%)
		Ig	501..560	CDD:299845	15/58 (26%)
		Ig	584..666	CDD:299845	21/84 (25%)
		IG_like	585..666	CDD:214653	21/83 (25%)
		I-set	678..767	CDD:254352	23/89 (26%)
		IGc2	692..757	CDD:197706	18/64 (28%)
		Ig	788..849	CDD:143165	13/64 (20%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
LOC110439986	XP_021333824.1	Ig_2	22..101	CDD:316418	23/89 (26%)
		Ig_2	115..186	CDD:316418	23/89 (26%)
		Ig_2	193..270	CDD:316418	22/86 (26%)
		Ig_2	284..355	CDD:316418	16/81 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010