DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and kirrel3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_031761736.1	Gene:	kirrel3 / 105947809	XenbaseID:	XB-GENE-922296	Length:	773	Species:	Xenopus tropicalis

Alignment Length:	844	Identity:	177/844 - (20%)
Similarity:	273/844 - (32%)	Gaps:	300/844 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 QQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYN 135
            |..|...|.|..|:.|....:.|.:....|.:.|.|||.|:|....:.|:|||||.||...|.::
Frog    43 QSSFTQQPQDQVVVAGQPVSLLCAIPGYHGLLLWIKDGLAIGVGRDLSGYPRYSVGGDHLSGEHH 107

  Fly   136 LRISNASINDDADYQCQVGPARLNSAIRAN-AKLTVISPPASIEIKGYSHNSKVEVRENQDLQLK 199
            |.|..|.:.|||.|:||.    :.:|||:. |:|||:.||....|.|   ...:.:|....|.|.
Frog   108 LMIQRAELQDDAMYECQA----IQAAIRSRPARLTVLVPPDDPVITG---GPVISIRAGDPLNLT 165

  Fly   200 CIVANAKPAAQIVWYR------GNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTC 258
            |...||||||.|.|.:      |...||...|:...|...:..|.::|.:       ::....||
Frog   166 CHADNAKPAATITWMKNGEVLNGATYYKTLLRDGKRESIISTLFVSSSDI-------ENGQTITC 223

  Fly   259 QARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKN 323
            :|.:||:...  ..|||.:::.:||
Frog   224 RATNKAVPGG--KEATVTINIQHPP---------------------------------------- 246

  Fly   324 GSQIRMAYRTSGRLSENIYTFTAE----AGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVT 384
                             :...|.|    ..||..:|.|
Frog   247 -----------------LVNLTVEPQPVLEDNVVKFHC--------------------------- 267

  Fly   385 VMGPTEARVGDIVPLTCTTAPSNPP-AEIKWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEP 448
                              .|.:||. .:.:|..||:.::..|.:|       :.|..:.:...||
Frog   268 ------------------AAKANPAVTQYRWAKGGQILKEVTDET-------YETVVDFSFFTEP 307

  Fly   449 NKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLA 513
                  |.|...|...:.||  :.|::|.:.|.   :|...|...:..||.....|... |||..
Frog   308 ------VSCEVTNALGSTNV--SRTVDVYFGPR---MSSEPESITVDLGSDATFHCAWI-GNPSL 360

  Fly   514 TLTWYKNDKRINSVIRAADKSVSAEITI-LANVSDNQA-QYRCEA------------SNSATEIP 564
            |:.|.|         |.:...:|.|.|: |.||....| :|.|.|            |.:....|
Frog   361 TIVWMK---------RGSGVVLSNENTLTLKNVRQEDAGKYVCRAVVPRVGAGERDISLTVNGPP 416

  Fly   565 LFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDSSSSNPPAKLSW-WKDGIPIEGIN----- 623
            :..||               :.:....|.:..|.|...|:.||.:::| ||:.:...|.:
Frog   417 IISST---------------QTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTV 466

  Fly   624 ---NTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDV-LYRPKFVPPP 684
               :|.:     |.:|||... |:.:.....:|.|         :|..:...|. :.|.|...|.
Frog   467 ETVSTDE-----GVISTLTIS-NIVRADFQTIYNC---------TAWNSFGSDTEIIRLKEQGPN 516

  Fly   685 SSTAVGVEGESLQVSL-------------------------QTRAN-----------------PT 707
            ..:...:|.||:.|::                         :.:.|                 ..
Frog   517 MQSGTSMEPESVPVTVIIGVAVGAGVAFLVLMATIVAFCCARNQRNLKGVVSAKNDIRVEIVHKE 581

  Fly   708 PVTYKWTKDGTTIPQDGDHRIFADGGSL-----------------NFTRLHRDDAGIYS------ 749
            |.|.:.|:|.:||.|     :..|.|..                 .|..|.....|.||
Frog   582 PSTGRETEDHSTIKQ-----LMIDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKD 641

  Fly   750 -----CSASNSQ-------------GGATLNITVVVEYGTTIKSVSENIVVNPGEDAMLSCTVE 795
                 .|.||.|             |.:..||...:.....:...|:..|:..|..::..|..|
Frog   642 HSTPTISLSNCQQDLRPANKQRVPTGMSFTNIYSTLSGQNRLYDYSQRFVLGMGSSSIELCERE 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	36/97 (37%)
		Ig	76..155	CDD:299845	30/78 (38%)
		IG_like	186..279	CDD:214653	27/98 (28%)
		Ig	197..279	CDD:299845	25/87 (29%)
		IG_like	296..376	CDD:214653	6/83 (7%)
		Ig	300..361	CDD:299845	6/64 (9%)
		Ig	380..454	CDD:299845	11/74 (15%)
		IG_like	490..573	CDD:214653	25/96 (26%)
		Ig	501..560	CDD:299845	19/72 (26%)
		Ig	584..666	CDD:299845	18/90 (20%)
		IG_like	585..666	CDD:214653	18/89 (20%)
		I-set	678..767	CDD:254352	28/171 (16%)
		IGc2	692..757	CDD:197706	23/147 (16%)
		Ig	788..849	CDD:143165	2/8 (25%)
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
kirrel3	XP_031761736.1	IG	50..139	CDD:214652	35/92 (38%)
		IgI_2_KIRREL3-like	145..242	CDD:409416	29/108 (27%)
		Ig strand B	162..166	CDD:409416	2/3 (67%)
		Ig strand C	176..180	CDD:409416	1/3 (33%)
		Ig strand E	206..210	CDD:409416	0/3 (0%)
		Ig strand F	220..225	CDD:409416	2/4 (50%)
		Ig strand G	235..238	CDD:409416	1/2 (50%)
		Ig	331..412	CDD:416386	24/93 (26%)
		Ig strand A'	339..343	CDD:409353	0/3 (0%)
		Ig strand B	346..356	CDD:409353	2/10 (20%)
		Ig strand C	361..367	CDD:409353	3/14 (21%)
		Ig strand E	377..383	CDD:409353	2/5 (40%)
		IgI_5_KIRREL3	414..511	CDD:409479	24/126 (19%)
		Ig strand B	432..436	CDD:409479	1/3 (33%)
		Ig strand C	446..450	CDD:409479	0/3 (0%)
		Ig strand E	477..481	CDD:409479	3/3 (100%)
		Ig strand F	492..497	CDD:409479	2/13 (15%)
		Ig strand G	505..508	CDD:409479	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010