DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and LOC100494743

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_031755242.1	Gene:	LOC100494743 / 100494743	-ID:	-	Length:	512	Species:	Xenopus tropicalis

Alignment Length:	547	Identity:	113/547 - (20%)
Similarity:	197/547 - (36%)	Gaps:	174/547 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 ETLRRGQTVELMCRSRGGNPPAQL----------IW---YKNGSQIRMAYRTSGRLSENI-YTFT 345
            :.|..|::..:.|...|..|...|          |:   :|:.|::       |.::|.: |..|
Frog     3 DMLEEGKSYIITCTVHGVAPIQNLRVTILRGKEEIYNKTFKDDSRV-------GNITEPVTYQIT 60

  Fly   346 AEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTA-----P 405
            ||..||...|.|:|:..:.                   ||:|      ...||....|.     |
Frog    61 AERSDNMEDFSCQATLALG-------------------TVIG------NKTVPSANVTVRTFALP 100

  Fly   406 SNPPAEI-KWMVGGRQVRNATSKTIVSPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVV 469
            ..|..|: :|:..|.               |...|..::....|...:|.:|.:.:.:.:.:..:
Frog   101 DKPKLEVNQWIEIGT---------------GQMATCKVSNAFPPEHLNLTMIFNTITLSMNKTKM 150

  Fly   470 STHTI--NVLYPPAPPLISGYMEGQIIPAGSVQKLLC----VSSGGNPLATLTWYK--------- 519
            :..::  :...|| ..|:..|            :|||    ||........:..|:
Frog   151 ADGSVLGSAGIPP-DTLLGTY------------RLLCKAELVSLSSEASTDIHIYELPDISFTVS 202

  Fly   520 NDKRI--------------NS-----VIRAADKSVSAEITILANVSDN----QAQYRCEA-SNSA 560
            ||..:              ||     .||...:.:..:..:..||..|    |:...||| ....
Frog   203 NDSVLLGDSITASCLLNNNNSDPYGVTIRLNGEEICKDPAMDCNVPVNRRSPQSLVSCEAFIKDN 267

  Fly   561 TEIPLFQSTTLSVHFAPETVKIRIEPEE------LRPGMEATIICDSSSSNPPA----KLSWWKD 615
            |:|.:.:..:|:||::|:     .:.::      ||.|......|.:..:.||.    :.||
Frog   268 TDITVRREKSLTVHYSPQ-----FQDDQCPGHFALREGNNGPFKCQADGNPPPTVTCRRDSW--- 324

  Fly   616 GIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKF 680
            .:|.:                 ..|.:|.|.  :|| |.||:.||...:|  ::|.::|.|.|
Frog   325 NLPTD-----------------RTFDINRTH--SGQ-YECQATNEHGVQS--KSVMVEVQYPP-- 365

  Fly   681 VPPPSSTAVGV----EGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNF-TRL 740
             ..|:.|||..    :|.:|.|:......|.| .|:|     .|| :|...::.:..|:.| ...
Frog   366 -ATPNITAVPTATIPKGGALNVTCWADGLPQP-EYRW-----EIP-NGASVVYMNNNSVIFIPET 422

  Fly   741 HRDDAGIYSCSASNSQGGATLNITVVV 767
            ....:|.|:|.|.|..||:::.:.:.|
Frog   423 STSHSGTYTCHAVNQHGGSSVALVITV 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653	20/93 (22%)
		Ig	300..361	CDD:299845	19/74 (26%)
		Ig	380..454	CDD:299845	14/79 (18%)
		IG_like	490..573	CDD:214653	22/119 (18%)
		Ig	501..560	CDD:299845	19/95 (20%)
		Ig	584..666	CDD:299845	19/91 (21%)
		IG_like	585..666	CDD:214653	19/90 (21%)
		I-set	678..767	CDD:254352	24/93 (26%)
		IGc2	692..757	CDD:197706	17/65 (26%)
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
LOC100494743	XP_031755242.1	Ig	8..78	CDD:416386	19/76 (25%)
		Ig strand B	10..19	CDD:409353	1/8 (13%)
		Ig strand C	26..32	CDD:409353	1/5 (20%)
		Ig strand C'	34..37	CDD:409353	0/2 (0%)
		Ig strand E	52..60	CDD:409353	2/7 (29%)
		Ig strand F	68..75	CDD:409353	2/6 (33%)
		Ig	284..361	CDD:416386	22/106 (21%)
		Ig strand B	303..307	CDD:409353	0/3 (0%)
		Ig strand C	316..320	CDD:409353	0/3 (0%)
		Ig strand E	331..334	CDD:409353	1/2 (50%)
		Ig strand F	341..346	CDD:409353	3/5 (60%)
		Ig strand G	355..358	CDD:409353	0/2 (0%)
		Ig_3	368..436	CDD:404760	20/74 (27%)
		Ig strand B	383..390	CDD:409353	2/6 (33%)
		Ig strand C	396..402	CDD:409353	3/11 (27%)
		Ig strand C'	405..414	CDD:409353	1/8 (13%)
		Ig strand E	417..423	CDD:409353	1/5 (20%)
		Ig strand F	426..437	CDD:409353	4/10 (40%)
		Ig strand G	440..450	CDD:409353	2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910