DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sns and pecam1

DIOPT Version :9

Sequence 1:NP_001036532.1 Gene:sns / 44097 FlyBaseID:FBgn0024189 Length:1542 Species:Drosophila melanogaster
Sequence 2:XP_031750419.1 Gene:pecam1 / 100493686 XenbaseID:XB-GENE-488102 Length:756 Species:Xenopus tropicalis


Alignment Length:724 Identity:137/724 - (18%)
Similarity:248/724 - (34%) Gaps:198/724 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   188 VEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRF---------TTTSSL 243
            |.:|...:|.|.|.|...|.             :.|..|.|.:.:..|.|         :..::.
 Frog    63 VTLRNGDNLSLTCFVQFIKG-------------ETESFELTTQFAFFKNFKQIYNVSSNSPNATY 114

  Fly   244 KLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCR 308
            :|.|.......:|.|:..   :...|.....|.::|.....|..  ..|...| :.|||:.:.|.
 Frog   115 RLSPARVSSSGQYQCKVH---VGQMMKQSGIVTITV
TGLSKPKL--SVSTNST-KEGQTIIVKCE 173

  Fly   309 SRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQNPLKAEVE 373
            :....||.:..:||..:.........|.:.                        .|:||...||.
 Frog   174 APEEEPPFRFTFYKMKNNGNKDMEVLGPIP------------------------TSENPASMEVS 214

  Fly   374 LSVLFAPTHVTVMGPTEARVGD-IVPLTC----TTAPSNPPAEIK-WMVGGRQVRNATSKTIVSP 432
            ::                 .|| ||...|    |:.|::..:::. ||:...:.:.:|.:..|||
 Frog   215 MA-----------------EGDRIVRFLCDVALTSLPNSNVSDLSDWMLVTVEQQFSTPRIEVSP 262

  Fly   433 EGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYPPAPPLISGYMEGQIIPAG 497
            ...:|           ..:.:.|.|   ::|.:.:|                           :|
 Frog   263 SLNFT-----------EGKEMSVKC---SIQTSSSV---------------------------SG 286

  Fly   498 SVQKLLCVSSGGNPLAT----LTWYKNDKRINSVIRAADKSVSAEITILANVSDNQAQYRCEA-- 556
            .||  |.:.:|.:.|.:    ..||..        ||.:              .:..||.|:|  
 Frog   287 KVQ--LFIQNGTHILTSSKTDTVWYAQ--------RATE--------------SHSGQYICKAEY 327

  Fly   557 -------SNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATI--ICDSSSSNPPAKLSW 612
                   |.:.|...||:|.:|..:....|:     .|:.|..:..::  |..||:.|    .|.
 Frog   328 EQTSKSNSTNVTVTELFKSPSLYSNIRNSTM-----DEDARLSLSCSVQGISPSSAHN----FSL 383

  Fly   613 WKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYR 677
            .|||   :..:|:.|..::..|..:..:|..||      :......:..|....:..||     :
 Frog   384 LKDG---QIRSNSEKLEIYAKTSDSGTYRCMVT------ISNITKTSGDLPIRVYAPVS-----K 434

  Fly   678 PKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFADGGSLNFTRLHR 742
            |.......||::.|:|.::::..:......|:||...|..|.:....:....|....||.:  .:
 Frog   435 PLLSHRNQSTSMAVQGSTIELRCKCDKGTPPITYSLMKGSTVLSNITETEAKAAMFKLNIS--EQ 497

  Fly   743 DDAGIYSCSASNSQGGA-----TLNITVVVEY-GTTIKSVSENIVVNPGEDAMLSCTVEGKPLTE 801
            .::|.|.|.|.|....:     |:||||:... ..|:.::.::..|..|::..|.|.|:...|..
 Frog   498 QNSGQYRCRAYNLHSSSLGFSNTVNITVISPITEVTLTTIPQSGTVEEGKELSLVCAVKNGSLPI 562

  Fly   802 EHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRDIL-------- 858
            :.....:.|.:..:.:|...:...|...||.....|.|::.|.|.|......:.:::        
 Frog   563 DFHFLVKRGKESVLHSSMDKSVFHSETQIKSFSANDDGSYFCRATNGAHQTVDSNLVHVKAVLAT 627

  Fly   859 ----LIVKF 863
                ||:.|
 Frog   628 WKKGLIITF 636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snsNP_001036532.1 I-set 73..170 CDD:254352
Ig 76..155 CDD:299845
IG_like 186..279 CDD:214653 18/99 (18%)
Ig 197..279 CDD:299845 15/90 (17%)
IG_like 296..376 CDD:214653 15/79 (19%)
Ig 300..361 CDD:299845 9/60 (15%)
Ig 380..454 CDD:299845 14/79 (18%)
IG_like 490..573 CDD:214653 20/95 (21%)
Ig 501..560 CDD:299845 12/71 (17%)
Ig 584..666 CDD:299845 17/83 (20%)
IG_like 585..666 CDD:214653 17/82 (21%)
I-set 678..767 CDD:254352 23/93 (25%)
IGc2 692..757 CDD:197706 14/64 (22%)
Ig 788..849 CDD:143165 14/60 (23%)
Ig 885..960 CDD:143165
FN3 967..1051 CDD:238020
pecam1XP_031750419.1 IG 60..147 CDD:214652 18/99 (18%)
IG_like 261..340 CDD:214653 22/143 (15%)
IG 354..422 CDD:214652 17/85 (20%)
Ig_C17orf99 450..515 CDD:407611 14/66 (21%)
IG 538..621 CDD:214652 16/82 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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