DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and igsf9b

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_031761656.1	Gene:	igsf9b / 100379858	XenbaseID:	XB-GENE-5887265	Length:	1392	Species:	Xenopus tropicalis

Alignment Length:	1230	Identity:	286/1230 - (23%)
Similarity:	457/1230 - (37%)	Gaps:	327/1230 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 NVLYP----PAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAA--DK 533
            :|::|    |.|.::..:..|..||       :.:..|..|......|        |.|||  ||
Frog    46 DVVHPLTVQPPPYVVEWFKFGVPIP-------IFIKFGFYPPHVDPEY--------VGRAALYDK 95

  Fly   534 SVSAEITILANVSDNQAQYRCEASNSATEIPLFQSTT---LSVHFAPETVKIRIEPEELRPGMEA 595
               |.:.|....|.:|..|.|:......:...|.:.:   |:|:..|...:...:..|::.|...
Frog    96 ---ASLRIEQVRSQDQGWYECKVLMLEHQYDTFHNGSWVHLTVNAPPTFTETPPQYLEVKEGSSI 157

  Fly   596 TIICDSSSSNPPAKLSWWKDGIPIEGINNTSKPGLWGG--TVSTLEFRVNVTQEMNGQVYTCQSA 658
            |:.| ::..||...:||.::|   |.:..|||..|..|  |:|      ::.:|..|. |.|::.
Frog   158 TLTC-TAFGNPKPTVSWLREG---EFLGRTSKYQLSDGSLTIS------SIGREDRGS-YMCRAT 211

  Fly   659 NEALQRSAHEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQD 723
              ::|..|..:..|.|...|..|.||.:..|.:..::| .:.|..|.|..:||.|......:...
Frog   212 --SIQGEAVHSTRLLVQGSPFIVSPPENITVNISQDAL-FTCQAEAYPGNLTYTWYWQEENVFFK 273

  Fly   724 GD----HRIFADGGSLNFTRLHRDDAGIYSCSASNSQG-GATLNITVVVEYGTTIKSVSENIVVN 783
            .|    .||..||..:.| |:..:|||.|:|..|||.| ..:.:..:.|:|...:.::...|.|.
Frog   274 NDLKLRVRILIDGTLIIF-RVKPEDAGKYTCVPSNSLGRSPSASAYLTVQYPARVVNMPPVIYVP 337

  Fly   784 PGEDAMLSCTVEG-KPLTEEHVKWERVGYDMTVKTSTTFA---NGTSYLHIKDAKREDVGNFRCV 844
            .|....:.|.||. .|:|  .|||.:.|..:.:...:.:.   :||  :|:::|..|.:|.:.||
Frog   338 VGIHGHIRCPVEAVPPVT--FVKWNKDGRPLRIDKFSGWKLLDDGT--IHVEEATEELLGTYTCV 398

  Fly   845 ADNRV----DNPTNRDILLIVKFAPEIAKTPTLLRAASGTGERGR---LPCRAQGSPKPQFIWRQ 902
            ..|.:    .:|..|   |::|..|..    |:|.......|.||   :||.|.|.|.|...||:
Frog   399 PYNALGTMGQSPPAR---LLLKDPPYF----TVLPGWEYRQEAGRELLIPCAAAGDPFPSISWRK 456

  Fly   903 DKKDLPINRTYKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELGEAVETVRLE-ITSQ 966
                  :.|....:.......||.:.|      ::..|:|.:||||.|.:.....:..|. |.:.
Frog   457 ------VGRPSFSKHSVLPSGSLQFRS------LSKEDHGEWECVASNVVTSITASAHLTVIGTS 509

  Fly   967 PDPPLSLNILNVTHDTVTLAWTPGFDGGLKASYRVRY-RMADREQYKYID--GLP---NSHKLTI 1025
            |..|.::.:: |:.:|..::|..|:|||.:.::.|.| .:..|.|:...|  .:|   .|..|.:
Frog   510 PHAPSNVRVV-VSMNTANVSWEAGYDGGFEQTFSVWYGALIKRAQFGPHDWVSMPVPSGSSFLLV 573

  Fly  1026 GGLRMNTLYLFSVMSWNELGQSSY-----LPDLARAETKEAP------PPSHPASSLGGG----- 1074
            ..|...|.|.|||::.|:||.||:     |..||...|...|      |....|:....|
Frog   574 DSLDPETEYQFSVLAQNKLGTSSFSEVVTLRTLAFPLTTPEPLLVLTSPRCLTANRTQQGVLLSW 638

  Fly  1075 -PPTTSQTPLGGTSGMLLVGVGAGIVVVLLNVFVIGCCLHKR----NEKRLKRGLELMPAELTED 1134
             ||:....|                    |:.:::...|.:|    ::..|....|::..||::|
Frog   639 LPPSNHSFP--------------------LDRYIMEFRLAERWEILDDSILGSDTEILAKELSQD 683

  Fly  1135 S-----------------SN-----------TPNL--------VIIGISLAAFGFL---LVNASL 1160
            :                 ||           :|:|        |:.|| :|...||   ::.::|
Frog   684 TWYEFRVLAVMQDLISEPSNIAGVSSSDVFPSPDLSEEGFARPVLAGI-VATICFLAAAILFSTL 747

  Fly  1161 VAWFFVHQR-----RKKVAET--TNQPAKTATI--EMYAPSSYNDTVTGETLSSVSEKSESYSNE 1216
            .|.....||     ||||:.:  |:.|......  .|.:|.| :..|:.|::.::...|||..::
Frog   748 AACVVNRQRKRKMKRKKVSHSCPTDPPLSITHCRKSMESPLS-SGKVSPESVRTLRAPSESSEDQ 811

  Fly  1217 GSSQPEYIDEVRKKAASTYLVEGSDMPPPRY-----QKDGTLPVIY-----PNNVVNACTLPHP- 1270
            |......:...|:|..|.|......|...:|     :.:.|.|:..     ....|.|.....|
Frog   812 GPPSKRPLSPGREKELSLYKKTKRAMTSKKYSVSQAEAEVTTPIELISRGPDGRFVTAGPEQEPT 876

  Fly  1271 ---RHNNGSAAIHMT-----------RDDQMLISKGVYIP----SPSPAPPP------------- 1304
               |...|......|           .:|:....|....|    ..||..||
Frog   877 LRSRRIQGFPFAEETDMYPEFRQSDEENDEPSGLKSQLTPLSSSQDSPLQPPAYSPRFQHQPSEG 941

  Fly  1305 ---------DGSYYNMNSDRYLSYPPMEYPAALDFTAQPMP---MAHLQPMTVTSLATNGGPTLI 1357
                     .|.|::.:...|||..|::        :.|.|   |..:.|::    :....|.|:
Frog   942 RQQPSGQSRPGGYHHGHLYGYLSSSPLD--------SDPPPPFYMPEVSPLS----SVMSSPPLL 994

  Fly  1358 GNGSVAAVAGGSG------TLRRGILRGVVGVPQPDVTHHTSTVGGSPMQM-LHDLHPVNLSAST 1415
            ..||...:...:|      ||              .:| ||.|.|.||.|. :.|...|.|.|..
Frog   995 PEGSFPPIPEENGENSSTSTL--------------PLT-HTPTGGRSPEQWGVPDFPFVGLEAPA 1044

  Fly  1416 LTT--------STTLNGSL--------------------PTATATLPRQPH----GILKD---PN 1445
            ..:        :|.:...|                    |:..|.||.:.|    |.|..   |.
Frog  1045 SPSLFVQHRYETTEIRRPLPPPPPLPFPHGHPPPSSLQVPSYAAILPLESHPGWVGRLPSRCPPP 1109

  Fly  1446 RNKQQQQQQQQQQQQQQLQHQQQLLNASLVGVGVPVSAPLGSLQILNLP----PASGGLG 1501
            .:...|....|...|.||:|..|       |:|:||           ||    |..|.||
Frog  1110 PHPSWQDAAMQLAAQGQLRHTSQ-------GMGIPV-----------LPYPDIPQPGPLG 1151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653
		Ig	197..279	CDD:299845
		IG_like	296..376	CDD:214653
		Ig	300..361	CDD:299845
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653	20/87 (23%)
		Ig	501..560	CDD:299845	15/60 (25%)
		Ig	584..666	CDD:299845	22/83 (27%)
		IG_like	585..666	CDD:214653	22/82 (27%)
		I-set	678..767	CDD:254352	28/93 (30%)
		IGc2	692..757	CDD:197706	22/68 (32%)
		Ig	788..849	CDD:143165	18/64 (28%)
		Ig	885..960	CDD:143165	20/77 (26%)
		FN3	967..1051	CDD:238020	28/94 (30%)
igsf9b	XP_031761656.1	IG	30..115	CDD:214652	22/86 (26%)
		I-set	139..225	CDD:400151	25/98 (26%)
		Ig strand A	139..142	CDD:409353	1/2 (50%)
		Ig strand A'	148..151	CDD:409353	0/2 (0%)
		Ig strand B	157..164	CDD:409353	2/7 (29%)
		Ig strand C	170..175	CDD:409353	2/4 (50%)
		Ig strand D	185..189	CDD:409353	1/3 (33%)
		Ig strand E	191..195	CDD:409353	1/3 (33%)
		Ig strand F	204..212	CDD:409353	3/10 (30%)
		Ig strand G	215..225	CDD:409353	2/9 (22%)
		I-set	229..321	CDD:400151	28/93 (30%)
		Ig strand B	246..250	CDD:409353	1/4 (25%)
		Ig strand C	260..264	CDD:409353	2/3 (67%)
		Ig strand E	286..290	CDD:409353	1/3 (33%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
		Ig strand G	314..317	CDD:409353	0/2 (0%)
		Ig	344..405	CDD:409353	18/64 (28%)
		Ig strand C	355..360	CDD:409353	3/6 (50%)
		Ig strand E	380..384	CDD:409353	2/5 (40%)
		Ig strand F	394..399	CDD:409353	1/4 (25%)
		Ig	429..505	CDD:416386	23/87 (26%)
		Ig strand A'	429..432	CDD:409353	0/2 (0%)
		Ig strand B	438..445	CDD:409353	2/6 (33%)
		Ig strand C	451..456	CDD:409353	1/4 (25%)
		Ig strand C'	458..460	CDD:409353	0/1 (0%)
		Ig strand E	471..476	CDD:409353	2/4 (50%)
		Ig strand F	484..492	CDD:409353	5/7 (71%)
		Ig strand G	495..505	CDD:409353	1/9 (11%)
		FN3	510..605	CDD:238020	29/95 (31%)
		FN3	622..703	CDD:238020	14/100 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910