DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and kirrel2

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001135598.1	Gene:	kirrel2 / 100216155	XenbaseID:	XB-GENE-854070	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	754	Identity:	192/754 - (25%)
Similarity:	280/754 - (37%)	Gaps:	175/754 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 IKHLQLLRLLAVIVLASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGFA 110
            :|:|.||..:.|.:|......:|..||     |.|..::.|....:.|.|....|.||||.||.|
Frog     1 MKNLWLLLWIHVGLLLGKSFGAHFSQQ-----PSDKVIVAGKSVTLPCVVIGYRGVVQWTMDGLA 60

  Fly   111 LGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPA 175
            ||....:||:.||||:||...|.:||.|....::|||.|:||...|.|.|   ..|:|||:.||.
Frog    61 LGAERDLPGWSRYSVVGDPSLGEHNLHIEGVELSDDAIYECQATQAALRS---QRARLTVLLPPG 122

  Fly   176 SIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYR-----GNVEYKPEKREDTVEESTAK 235
            ...|.|   :....|..|....|.|:...|||||:|.|||     .:..|..|...|...|.:|
Frog   123 DPMIPG---SPVANVLLNVPYNLTCLAPVAKPAAEITWYRDGKKLDSAVYTKELLSDGKSEGSA- 183

  Fly   236 RFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPP------GPPYIEGYSAG 294
                 |||.:.|...|..:.|||:.|::|| |: ....:|.|||.|||      .||
Frog   184 -----SSLLITPSLADSGSSYTCRVRNEAL-PE-GREKSVTLSVQYPPKVTLSVEPP-------- 233

  Fly   295 ETLRRGQTVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEA 359
             |:..|.:|..:|.:..........|.|.|..:        .:|.:.||...:.....|...||.
Frog   234 -TITEGGSVTFLCGAVSNPEVTGYRWAKGGVPL--------AVSGDKYTVEVDHTFFTAPVSCEV 289

  Fly   360 SNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNA 424
            ||.:..:.:...|  :|||.|..:|...|....:||.....|....:..|.:. |
Frog   290 SNSVGASNVSTAV--NVLFGPRLLTEPRPMTVDIGDDASFFCGWTGNPTPTQF-W---------- 341

  Fly   425 TSKTIVSPEGGWTTTSN-----ITAVVEPNKRSLVVICHGL--NMQLTENVVSTHTINVLYPPAP 482
                  |.:|.....||     :|.|...:  :.:.:|..:  .|..||..| |.|:.     .|
Frog   342 ------SKKGTGEVLSNGNTLLLTKVTRED--AGIYVCKAIVPRMGSTEKEV-TLTVR-----GP 392

  Fly   483 PLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADK-----------SVS 536
            |:|:..|..:....|..:....:.|...|             :.::.|.||           ||.
Frog   393 PIITSEMHYETTLGGKARMECLIESTPAP-------------DRIVWAWDKQSLEDGSWGRFSVE 444

  Fly   537 AEITIL----------ANVSDNQAQYRCEASNSATE------------IPLFQSTTLSVHFAPET 579
            .|:|.:          |..||...::.|.|.|...|            :||   |.|.:.....|
Frog   445 TEVTEVGAISVLVIDGAEQSDFLTEFNCSAINQYGEDSVIVSLRQQAALPL---TLLLIAVGSGT 506

  Fly   580 VKIRIEPEELRPGMEATIIC----------------DSSSSNPPAKLSWWKDGIPIEGINNTSKP 628
            :.|.:.       :..:|:|                |.|.|.|       .:..|.:...:..:|
Frog   507 LCIFVL-------VITSILCCRRPKKAVKDTQILAVDVSGSEP-------SERHPSDSEEDLKEP 557

  Fly   629 GLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSAHEAVSLDVLYRPKFVPPP----SSTAV 689
             |...|.|.   |.:.|:..:.........|...:..|||......:..|:|..||    |:|:
Frog   558 -LHTDTESQ---RTSQTEHSDIPDEPQDPTNGYYKVRAHEDTRPTTITYPEFSSPPRPLYSTTS- 617

  Fly   690 GVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRI 728
                 ||.....|.:.| |..|.:.....|.|:.|.|.:
Frog   618 -----SLSPLCPTPSGP-PKIYDYAHRYATTPRSGGHHM 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	38/96 (40%)
		Ig	76..155	CDD:299845	33/78 (42%)
		IG_like	186..279	CDD:214653	32/97 (33%)
		Ig	197..279	CDD:299845	30/86 (35%)
		IG_like	296..376	CDD:214653	16/79 (20%)
		Ig	300..361	CDD:299845	12/60 (20%)
		Ig	380..454	CDD:299845	14/78 (18%)
		IG_like	490..573	CDD:214653	21/115 (18%)
		Ig	501..560	CDD:299845	15/79 (19%)
		Ig	584..666	CDD:299845	14/97 (14%)
		IG_like	585..666	CDD:214653	14/96 (15%)
		I-set	678..767	CDD:254352	16/55 (29%)
		IGc2	692..757	CDD:197706	10/37 (27%)
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
kirrel2	NP_001135598.1	IG_like	28..117	CDD:214653	38/91 (42%)
		Ig2_KIRREL3-like	139..220	CDD:143236	30/88 (34%)
		Ig_2	225..294	CDD:372793	17/85 (20%)
		Ig	308..389	CDD:386229	20/100 (20%)
		Ig	391..488	CDD:386229	21/109 (19%)
		Atrophin-1	529..>765	CDD:367360	31/140 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3304
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010