DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and kirrel1b

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_017212964.1	Gene:	kirrel1b / 100170816	ZFINID:	ZDB-GENE-070912-173	Length:	801	Species:	Danio rerio

Alignment Length:	771	Identity:	187/771 - (24%)
Similarity:	290/771 - (37%)	Gaps:	172/771 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 WIKHLQLLRLLAVIVLASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQWTKDGF 109
            ||..|.::.:..|.   |.|        :|...|.|..|:.|...::.|.|.|..|.|||||||.
Zfish     9 WIVTLAIISVHRVF---SGP--------RFSQEPADQSVVIGERVVLSCVVFNYTGIVQWTKDGL 62

  Fly   110 ALGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPP 174
            |||....:..:|||.||.....|.|||.|::|.:.||:.|:||...|.|.|   ..|||||:.||
Zfish    63 ALGIGEDLRAWPRYRVLRIMDVGQYNLEITSADLTDDSLYECQATEAALRS---RRAKLTVLIPP 124

  Fly   175 ASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTT 239
            ....|:|   :.::.:.......|.|:...|||.:.|.||:..:..: .....|...|..||.||
Zfish   125 DGPVIEG---SPEILLTAGTSFNLTCVSRGAKPMSTIEWYKDGIIVE-GAHTSTEVLSDRKRVTT 185

  Fly   240 TSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPY-IEGYSAGETLRRGQTV 303
            .|.|:::|...|....:||.|.:  |:..:..|:||.|::.:||.... ||..|..|    |:.|
Zfish   186 KSFLEIQPMDTDTGRNFTCVASN--LAAPLGKRSTVTLNIHHPPTVILSIEPRSVLE----GERV 244

  Fly   304 ELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYTFTAEAGDNKARFRCEASNVMSQNPL 368
            :..|::....|.....|.|.|..:..|       .|:::..||:.........|...|.:...
Zfish   245 KFTCQATANPPIMGYRWAKGGVILDGA-------RESVFETTADHSFFTEPVSCLVFNAVGST-- 300

  Fly   369 KAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGG-------------RQ 420
            ...:.:.|.|.|..|....|....|...|.|.|..: .|||..:.|...|             :.
Zfish   301 NVSILVDVHFGPILVVEPRPVTVDVDSDVTLNCKWS-GNPPLTLTWTKKGSSMVLSNSNQLFLKS 364

  Fly   421 VRNATS-----KTIVSPEGGWTTTSNITAVVEP--NKRSLVVICHGLNMQLTENVVSTHTINVLY 478
            |..|.:     |.||...|...|...:|....|  :...:.....|...::...:.||
Zfish   365 VSQADAGQYVCKAIVPRIGVGETEVTLTVNGPPIISSEPIQYAVRGEKGEIKCYIAST------- 422

  Fly   479 PPAPPLISGYME-------GQIIPAGSVQKLLCVSSGGNPLATLTWYKNDKRINSVIRAADKSVS 536
            ||...::..:.|       |.::...:|::....:.||..|:|||       ||:|:.|
Zfish   423 PPPDKIVWAWKENVWEKERGTLLERYTVEQSRPATQGGAVLSTLT-------INNVMEA------ 474

  Fly   537 AEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDS 601
                      |.|:.|.|.|.|:               |.|.|:.|.:|..::..
Zfish   475 ----------DFQSTYNCTAWNA---------------FGPGTMIITLEETDIAS---------- 504

  Fly   602 SSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVST----------LEF---------RVNVTQE 647
                        :|.:|: |:       :.||:|.:          |.|         |..||.:
Zfish   505 ------------EDIVPV-GV-------IAGGSVGSSILLLLLLFALIFYLYRQRKSSRRGVTLK 549

  Fly   648 MNGQVYTCQSANEALQRSAHEAVS---LDVLYRPKFVPPPS---STAVGVEGESLQVSLQTRANP 706
            .:.:|.|........:.:|..:.:   :..:|  .|:|..|   ||....:...|:..|||....
Zfish   550 PDIKVETVNKETNLEEEAASASTATRMVKAMY--SFLPSVSLSPSTQPFKDDMDLKQDLQTETLE 612

  Fly   707 TPVTYKWTKDGTTIPQDGDHRIFA----DGGSLNFTRLHRDDAGIYSCSASNSQGG 758
            ..|.....||    |.:|.:.:.|    :..|...:.|:::.......|.|.|.||
Zfish   613 PKVEEYEAKD----PTNGYYNVRATTHDEVRSSTRSLLYQEFRAPNPASVSASTGG 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	41/96 (43%)
		Ig	76..155	CDD:299845	34/78 (44%)
		IG_like	186..279	CDD:214653	26/92 (28%)
		Ig	197..279	CDD:299845	26/81 (32%)
		IG_like	296..376	CDD:214653	13/79 (16%)
		Ig	300..361	CDD:299845	12/60 (20%)
		Ig	380..454	CDD:299845	21/93 (23%)
		IG_like	490..573	CDD:214653	19/89 (21%)
		Ig	501..560	CDD:299845	16/58 (28%)
		Ig	584..666	CDD:299845	14/100 (14%)
		IG_like	585..666	CDD:214653	14/99 (14%)
		I-set	678..767	CDD:254352	22/88 (25%)
		IGc2	692..757	CDD:197706	15/68 (22%)
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
kirrel1b	XP_017212964.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920