DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and btn2a1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	XP_012808960.1	Gene:	btn2a1 / 100170443	XenbaseID:	XB-GENE-6459012	Length:	347	Species:	Xenopus tropicalis

Alignment Length:	404	Identity:	69/404 - (17%)
Similarity:	126/404 - (31%)	Gaps:	156/404 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 CRQHWIKHLQLLRLLAVIVLASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGA---- 101
            |..|       ..::|..:|.|....|.:.:.|..:.|..:..| |::.::...:|....|
Frog     3 CNMH-------KTMIAFSILWSLYKGSLSAKYKVVSAPSVVATL-GSDVVLTARLAPEMNAEKME 59

  Fly   102 VQWTKDGFAL----------GFSAVIPGFP-RYSVLGDR-KQGIYNLRISNASINDDADYQCQVG 154
            ::|.|..:..          .::|.:|.|. |..:|.:. .:||:.|.|.|.::.|...|.|.|.
Frog    60 IRWFKPMYRPYVHLYINGKDDYTAQMPQFANRTELLKENITRGIFPLIIRNVTVQDSGKYYCYVE 124

  Fly   155 PARLNSAIRANAKLTVISPPASIEIKGYS--HNSKVE-VRENQDLQLKCIVANAKPAAQIVWYRG 216
            .:..:.       :|.:.  .::.:.|:|  |:.|.. ||..:|:.:.
Frog   125 SSDHHG-------ITTVY--LNVNVPGHSKTHSHKESGVRIPRDVSIN----------------- 163

  Fly   217 NVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLY 281
                  ::|:...:.|                                   |.|....|
Frog   164 ------QERQSQAQRS-----------------------------------DSPKEGAV------ 181

  Fly   282 PPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKN-GSQIRMAYRTSGRLSENIYTFT 345
              |.|.:......:|        :.|.|.|..|...|||..| |:::             |.:..
Frog   182 --GSPPVISVITDDT--------VFCESDGWYPEPYLIWTDNEGNKV-------------IPSME 223

  Fly   346 AEAGDNKARFRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPS-NPP 409
            ....|.|:.:..                ||.::.|       ||.:.:      |||.:.| |..
Frog   224 KVLKDEKSLYHI----------------LSAIYLP-------PTSSNI------TCTVSSSLNQS 259

  Fly   410 AEIKWMVGGRQVRN 423
            .|....:  |:.|:
Frog   260 KESSMQI--RETRH 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	22/112 (20%)
		Ig	76..155	CDD:299845	21/94 (22%)
		IG_like	186..279	CDD:214653	9/93 (10%)
		Ig	197..279	CDD:299845	5/81 (6%)
		IG_like	296..376	CDD:214653	14/80 (18%)
		Ig	300..361	CDD:299845	12/61 (20%)
		Ig	380..454	CDD:299845	11/45 (24%)
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
btn2a1	XP_012808960.1	Ig	40..138	CDD:386229	20/106 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910