DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and si:ch211-66e2.3

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001108576.1	Gene:	si:ch211-66e2.3 / 100141487	ZFINID:	ZDB-GENE-080226-7	Length:	315	Species:	Danio rerio

Alignment Length:	335	Identity:	73/335 - (21%)
Similarity:	121/335 - (36%)	Gaps:	68/335 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RRCRQHWIKHLQLLRLLAVIVLASAPVPSHAQQQKFRTTPHDLQVLEGAEAMMRCEVANVAGAVQ 103
            |.|...::..|..|.|..  .||..|:         :.||..:.|..|....:.|..
Zfish     2 RFCGLVYLSALSQLCLRG--TLAKCPL---------QITPQSVVVKYGDPVSVNCST-------- 47

  Fly   104 WTKDGFALGFSAVIPGFPRYSVLGDRKQGIYNLRISNAS-----INDDADYQCQVGPARLNSAIR 163
             :.....:|:.:.:.|.|                :|.||     :::..|::.|.....:|...:
Zfish    48 -SVTHMGMGWESTVGGVP----------------LSTASLITWRVSELTDWEIQPPFCYINYGKQ 95

  Fly   164 ANAKL--TVISPPASIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIV--WYRGNVEYKPEK 224
            ....|  ||...|.|:.|   |..::..:..|| .:|:|.|.|..|..::.  ||:|........
Zfish    96 CEVALPVTVYKTPDSVSI---STVNQTMIEGNQ-YELQCDVYNVAPVQKLTVNWYKGETLVDQTS 156

  Fly   225 REDTVEESTAKRFTTTSSLKLKPGPDDDYTEYTCQARHK--ALSPDMPMRAT---VQLSVLYPPG 284
            ..||::....|    ||.|.::|...||..:..|:....  ...|..|...|   ::::|.|.|
Zfish   157 FTDTIKSPVNK----TSKLLIRPDRADDGAQIRCEVELNLGEEGPQPPPTNTSEPLRITVYYKP- 216

  Fly   285 PPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQLIWYKN--GSQIRMAYRTSGRLSENIYTFTAE 347
                :..::.|.:.....|.|.|..: .||.|...|:..  ..:|..:...|..||...||..|.
Zfish   217 ----KHSNSTEIISWSNDVSLNCTVK-ANPAAVYSWHSEHLTEKISSSVIQSSTLSPGNYTCIAT 276

  Fly   348 --AGDNKARF 355
              .|::|..|
Zfish   277 NFLGEDKKNF 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	15/103 (15%)
		Ig	76..155	CDD:299845	13/83 (16%)
		IG_like	186..279	CDD:214653	23/99 (23%)
		Ig	197..279	CDD:299845	21/88 (24%)
		IG_like	296..376	CDD:214653	17/64 (27%)
		Ig	300..361	CDD:299845	17/60 (28%)
		Ig	380..454	CDD:299845
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
si:ch211-66e2.3	NP_001108576.1	Ig	108..208	CDD:299845	27/107 (25%)
		Ig_3	215..277	CDD:290638	16/67 (24%)
		IG_like	230..288	CDD:214653	17/58 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910