DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and mhc1a

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001106381.1	Gene:	mhc1a / 100127185	XenbaseID:	XB-GENE-485307	Length:	350	Species:	Xenopus tropicalis

Alignment Length:	388	Identity:	89/388 - (22%)
Similarity:	129/388 - (33%)	Gaps:	126/388 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LGFSAVIPGFPRYSVLGDRKQGIYNLRISNASINDDADYQCQVGPARLNSAIRANAKLTVISPPA 175
            ||.|||      ||       |.::||.....::|.|                       ...|
Frog    12 LGVSAV------YS-------GSHSLRYYYTGVSDRA-----------------------FGLP- 39

  Fly   176 SIEIKGYSHNSKVEVRENQDLQLKCIVANAKPAAQIVWYRGN--VEY-----KPEKREDTVEEST 233
            ...|.||...::: ||.:.|      ...|:||.|  |.:.|  .||     :..|..:.|.:..
Frog    40 EFSIVGYVDETQI-VRYSSD------NGRAEPATQ--WMKQNEGPEYWDRQTQNSKGTEPVYKHN 95

  Fly   234 AK----RFTTTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRATVQLSVLYPPGPPYIEGYSAG 294
            .|    ||..||      |.......|.|:.|.     |...|...|.            ||...
Frog    96 VKVAMDRFNQTS------GTHSLQYMYGCELRE-----DGSTRGYEQF------------GYDGR 137

  Fly   295 ETL----RRGQTVELMCRSRGGNPPAQLIWYK-NGSQIRMAYRTSGRLSENIYTFTAEAGDNKAR 354
            |.:    .|.:.|..|       ..|||...| |..::....|....| |||
Frog   138 ELMALDTERWRYVPSM-------REAQLSTQKWNSPEVNEPERERNYL-ENI------------- 181

  Fly   355 FRCEASNVMSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNP-PAEIKWMVGG 418
              |..:........:||:|..|   ..||.:   ::.:..||..|.|......| ..::||:..|
Frog   182 --CIPALKRYLGYGQAELERRV---RPHVKI---SDHQSDDITELRCQAYGFYPREIDVKWVRNG 238

  Fly   419 R-QVRNATSKTIV-SPEGGWTTTSNITAVVEPNKRSLVVICHGLNMQLTENVVSTHTINVLYP 479
            | .|.:..:|.|: :|:|.:..  .:||.|.| |......||..:..|.|.::      |::|
Frog   239 RDDVHSDEAKEILPNPDGSYQL--RVTAKVTP-KEGDSYACHVDHSSLEEKLI------VVWP 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	12/58 (21%)
		Ig	76..155	CDD:299845	12/43 (28%)
		IG_like	186..279	CDD:214653	25/103 (24%)
		Ig	197..279	CDD:299845	22/92 (24%)
		IG_like	296..376	CDD:214653	17/84 (20%)
		Ig	300..361	CDD:299845	13/61 (21%)
		Ig	380..454	CDD:299845	21/76 (28%)
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
mhc1a	NP_001106381.1	MHC_I	20..197	CDD:298647	52/255 (20%)
mhc1a	NP_001106381.1	IgC_MHC_I_alpha3	201..292	CDD:143322	27/105 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910