DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sns and jam2a

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001091734.1	Gene:	jam2a / 100005261	ZFINID:	ZDB-GENE-031204-3	Length:	307	Species:	Danio rerio

Alignment Length:	320	Identity:	80/320 - (25%)
Similarity:	119/320 - (37%)	Gaps:	65/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 SHNSKVEVRENQDLQLKCIVANAKPA-AQIVWYRGNVEYKPEKREDTVEESTAKRFT-------- 238
            |.|.||||.|..|.:|.|.....|.. .:|.|.|      .:|.:|.......:||.
Zfish    23 SRNPKVEVHEFSDAELSCEFKTEKDTNPRIEWKR------KDKEKDVSFVYYGERFVGPFQDRAD 81

  Fly   239 -TTSSLKLKPGPDDDYTEYTCQARHKALSPDMPMRAT-VQLSVLYPPGPPYIEGYSAGETLRRGQ 301
             ..::::|:.....|..||.|:.  .|.|..:.:..| |.|.||.||..|..:..|:..|   |.
Zfish    82 IEGATVRLRRVTQADAGEYRCEV--SAPSDSISLGETNVTLRVLVPPQTPSCDVPSSALT---GS 141

  Fly   302 TVELMCRSRGGNPPAQLIWYKNGSQIRMAYRTSGRLSENIYT----FTAEAGDNKARFRCEASNV 362
            .|||.||.|...|||...|||:...:.:.: .:...:.|.:|    |...:..:..::.|||.|
Zfish   142 QVELRCRDRHSIPPAVYTWYKDNRALPIRH-PNATYTVNEFTGVLMFQTVSRSDAGQYHCEAKN- 204

  Fly   363 MSQNPLKAEVELSVLFAPTHVTVMGPTEARVGDIVPLTCTTAPSNPPAEIKWMVGGRQVRNATSK 427
             ...|.|:       ...||:.:.....|.|...|.|.|...                |..|...
Zfish   205 -GVGPPKS-------CQHTHMQIDDLNVAAVVSAVVLVCVIL----------------VLCAFGV 245

  Fly   428 TIVSPEGGWTTTSNITAVVEPNKRSL-VVICHGLNMQLTENV-VSTHTINVLY--PPAPP 483
            .:...:|.::         ....||. :..|||:....::|: .|.||.:..|  ||..|
Zfish   246 CLAHRQGYFS---------RHRGRSFWIPHCHGVTHISSQNLNPSEHTQHSGYSHPPKEP 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352
		Ig	76..155	CDD:299845
		IG_like	186..279	CDD:214653	26/103 (25%)
		Ig	197..279	CDD:299845	20/92 (22%)
		IG_like	296..376	CDD:214653	23/83 (28%)
		Ig	300..361	CDD:299845	19/64 (30%)
		Ig	380..454	CDD:299845	12/74 (16%)
		IG_like	490..573	CDD:214653
		Ig	501..560	CDD:299845
		Ig	584..666	CDD:299845
		IG_like	585..666	CDD:214653
		I-set	678..767	CDD:254352
		IGc2	692..757	CDD:197706
		Ig	788..849	CDD:143165
		Ig	885..960	CDD:143165
		FN3	967..1051	CDD:238020
jam2a	NP_001091734.1	IG_like	26..119	CDD:214653	24/100 (24%)
		Ig	28..123	CDD:299845	25/102 (25%)
		Ig_2	129..211	CDD:290606	24/87 (28%)
		IG_like	136..207	CDD:214653	21/76 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910