DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sns and si:ch73-208g10.1

DIOPT Version :9

Sequence 1:	NP_001036532.1	Gene:	sns / 44097	FlyBaseID:	FBgn0024189	Length:	1542	Species:	Drosophila melanogaster
Sequence 2:	NP_001091731.1	Gene:	si:ch73-208g10.1 / 100002730	ZFINID:	ZDB-GENE-040108-6	Length:	899	Species:	Danio rerio

Alignment Length:	966	Identity:	204/966 - (21%)
Similarity:	326/966 - (33%)	Gaps:	310/966 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 HDLQVLEGAEAMMRCEVANVAGA----VQWTKDGFALGFSAVIPGFPRYSVLGDRKQGIYN---- 135
            |...::||.:..::|:|.|||.|    |.|.|     |.:.|     ..:...|..:...|
Zfish   115 HTGPMIEGIQYELQCDVYNVAPAQSLTVNWYK-----GKTLV-----NQTSFTDTSKSSVNMTSY 169

  Fly   136 LRISNASINDDADYQCQVGPARLNSAIRA-NAKLTVISPPASIEIK---GYSHN-SKVEVRENQD 195
            |.|.....:::|.|:|:   |.||..... ....||.|.|.||.:|   ..|.| |:|.|.....
Zfish   170 LLIQPDRTDNEAQYRCE---AALNLGEEGPQPPPTVTSEPLSITVKYDCPISFNFSEVVVEYGAS 231

  Fly   196 LQLKCIVANAKPAAQIVWYRGNVEYKPEKREDTVEESTAKRFTTTSSLKLKPGPDDDY----TEY 256
            ..:.|       :|:...|.|   ...|..|:|| |.|::...|...:....|....|    ..:
Zfish   232 FSVNC-------SAETTKYLG---LSWELNEETV-EITSEISKTVDQMTEWEGKFSCYIYFNNTH 285

  Fly   257 TCQARHKAL---SPDMPMRATVQLSVLYPPGPPYIEGYSAGETLRRGQTVELMCRSRGGNPPAQL 318
            .|...:...   :||     :|.:|.:...||..:           |:..||.|......|...|
Zfish   286 PCSRTYSVTIYKTPD-----SVSISTVNHTGPMTV-----------GKQYELQCDVHNVAPAQSL 334

  Fly   319 I--WYKNGSQIRMAYRTSGRLSENIYTFTAEA--------------GDNKARFRCEASNVMSQN- 366
            .  |||..:.:          ::..:|.|:::              .|::|::||||...:.:.
Zfish   335 TVKWYKGDTLV----------NQTSFTDTSKSPVSKTSKLLIHPNRNDDRAQYRCEAELNLGEEG 389

  Fly   367 ----PLKAEVELSVLFAPTHVTVMG-PTE-------ARVGDIVPLTCTTAPSNPPAEIKW--MVG 417
                |......||:.....|:...| |.|       .:.|..|...|.:..  |...|.|  .||
Zfish   390 PQPPPKNKSKPLSITVQSHHILDGGCPIELKPRRAVVKYGSSVSADCKSFV--PHDGIGWESTVG 452

  Fly   418 GRQVRNATSKTIVSPEGGWTTTSNITAVVEP-----NKRSLVVICHGLNMQLTENVVSTHTINVL 477
            |..:..|:..|       |..:......::|     |.:....:...:.:..|.:.||...:|
Zfish   453 GVPLSKASLIT-------WRVSQLTDWEIQPPFCYINYKQQCEVALPVTIYKTPDSVSISAVN-- 508

  Fly   478 YPPAPPLISGYMEGQIIPAGSVQKLLCVSSGGNPLATLT--WYKNDKRINSV----IRAADKSVS 536
                          |.:..|:..:|.|......|..:||  |||.:..:|..    ...:..:::
Zfish   509 --------------QAMTEGNQYELQCDVHNVAPAQSLTVNWYKGETLVNQTNFTDTTKSPVNIT 559

  Fly   537 AEITILANVSDNQAQYRCEASNSATEIPLFQSTTLSVHFAPETVKIRIEPEELRPGMEATIICDS 601
            :.:.|....:||.||:|||.                               ||..|.|
Zfish   560 SYLLIHPVRADNGAQFRCET-------------------------------ELNLGEE------- 586

  Fly   602 SSSNPPAKLSWWKDGIPIEGINNTSKPGLWGGTVSTLEFRVNVTQEMNGQVYTCQSANEALQRSA 666
             ...||.|              |||||         |...|:...|    :.:||      ..|.
Zfish   587 -GPQPPPK--------------NTSKP---------LSIPVHYAPE----IKSCQ------PWSP 617

  Fly   667 HEAVSLDVLYRPKFVPPPSSTAVGVEGESLQVSLQTRANPTPVTYKWTKDGTTIPQDGDHRIFAD 731
            .:..|||..  ||.:    .:.||              ||.| :..|..:.:.:.....
Zfish   618 KKGSSLDSY--PKHL----HSVVG--------------NPHP-SISWKHNSSPVNASAP------ 655

  Fly   732 GGSLNFTRLHRDDAGIYSCSASNSQGGATLNITVVVEYGTTI-----KSVSENIVVNPGEDAMLS 791
                    |...|:|.|..:|||..|.:...|::.|||...:     ..|.|..|.:|
Zfish   656 --------LTETDSGQYEITASNHYGESNCTISITVEYSPELICEESYEVKEKTVFSP------- 705

  Fly   792 CTVEGKPLTEEHVKWERVGYDMTVKTSTTFANGTSYLHIKDAKREDVGNFRCVADNRVDNPTNRD 856
            |.|||:|..|                .:.:..|.........|..|.|.::..|.|: ....|:.
Zfish   706 CDVEGEPKPE----------------LSLYKEGKRIQLFNGFKWNDSGLYQLTARNK-HGSVNKS 753

  Fly   857 ILLIVKFAPE---------IAKTPTLLRAASGTGERGRLPCRAQGSPKPQFIWRQDKKDLPINRT 912
            :.:.|::||.         :||...::           |.|.:.|:|:|:..|..:.|::...|.
Zfish   754 LTINVQYAPRLFASQQDFVVAKDYRII-----------LQCNSSGNPEPEMWWSFNNKNISTGRR 807

  Fly   913 YKYEVEERKIDSLTYESTLIVDKVAPADYGAYECVARNELG--EAVETVRLEITSQ 966
            |           :|:.    ::|......|.|.|:||||:|  |.|.||:::..|:
Zfish   808 Y-----------ITFN----IEKATSTSAGNYTCIARNEIGRQEKVFTVKIKDNSR 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sns	NP_001036532.1	I-set	73..170	CDD:254352	24/99 (24%)
		Ig	76..155	CDD:299845	21/83 (25%)
		IG_like	186..279	CDD:214653	20/99 (20%)
		Ig	197..279	CDD:299845	17/88 (19%)
		IG_like	296..376	CDD:214653	19/100 (19%)
		Ig	300..361	CDD:299845	17/76 (22%)
		Ig	380..454	CDD:299845	18/88 (20%)
		IG_like	490..573	CDD:214653	19/88 (22%)
		Ig	501..560	CDD:299845	17/64 (27%)
		Ig	584..666	CDD:299845	17/81 (21%)
		IG_like	585..666	CDD:214653	17/80 (21%)
		I-set	678..767	CDD:254352	17/88 (19%)
		IGc2	692..757	CDD:197706	11/64 (17%)
		Ig	788..849	CDD:143165	12/60 (20%)
		Ig	885..960	CDD:143165	22/76 (29%)
		FN3	967..1051	CDD:238020	204/966 (21%)
si:ch73-208g10.1	NP_001091731.1	Ig	105..207	CDD:299845	27/104 (26%)
		Ig	299..401	CDD:299845	24/127 (19%)
		Ig2_ICAM-1_like	499..599	CDD:143232	34/177 (19%)
		Ig	635..684	CDD:299845	14/77 (18%)
		IG_like	693..758	CDD:214653	17/88 (19%)
		IGc2	701..748	CDD:197706	14/70 (20%)
		I-set	769..843	CDD:254352	25/99 (25%)
		Ig	776..843	CDD:299845	23/92 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910