Protein Alignment wit and ACVRL1

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_000011.2
• Gene: ACVRL1 / 94
• HGNCID: 175
• Length: 503
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 154/573 - (26%)
• Similarity: 230/573 - (40%)
• Gaps: 119/573 - (20%)

  Fly     5 IYLLLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRR-- 67
            :.||:||::.|                         |..:.|.|.|.....||      ||.:
Human    11 LMLLMALVTQG-------------------------DPVKPSRGPLVTCTCES------PHCKGP 44

  Fly    68 TCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCCSGGVC 132
            ||...:  |..:..:.........:||  .|..|       |.....||...:  :|||.| .:|
Human    45 TCRGAW--CTVVLVREEGRHPQEHRGC--GNLHR-------ELCRGRPTEFVN--HYCCDS-HLC 95

  Fly   133 NAQYSVVEPA---PLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTAL-TIGIFLAVQYC 193
            |...|:|..|   |.|....:|:.::                :||....|.|| .:|: |.:.:.
Human    96 NHNVSLVLEATQPPSEQPGTDGQLAL----------------ILGPVLALLALVALGV-LGLWHV 143

  Fly   194 RTAKEKPEPEESPLAPS---------GPGYSSNLRNVD-------------------NMNLIGML 230
            |..:||.....|.|..|         |.....:|.:.|                   .:.|:..:
Human   144 RRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECV 208

  Fly   231 GSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRME 295
            |.|:||.|.:||.|.:.|||||:.....|.:..|..||...|:....:|.:...| ..:.:...:
Human   209 GKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASD-MTSRNSSTQ 272

  Fly   296 YQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNV 360
            ..|:......|.|.|:|...||.......:..|...|::|||.|: .|.|.||.:||||..:|||
Human   273 LWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEI-FGTQGKPAIAHRDFKSRNV 336

  Fly   361 LVQADLSCCIADFGFA-LKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETS 424
            ||:::|.|||||.|.| :...||.|        .:..:...|||.||||||:|:..:. .||..|
Human   337 LVKSNLQCCIADLGLAVMHSQGSDY--------LDIGNNPRVGTKRYMAPEVLDEQIR-TDCFES 392

  Fly   425 LKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPT 489
            .|..|::|.||||||:|.|.    ........|:.|:...|.:.|||:.|:.:|...:..|..|.
Human   393 YKWTDIWAFGLVLWEIARRT----IVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPN 453

  Fly   490 GWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSP 542
            ..........:.....:||..:..||||:|..::.:|::|.       .|..|
Human   454 RLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISN-------SPEKP 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	24/114 (21%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	99/300 (33%)
ACVRL1	NP_000011.2	TFP_LU_ECD_ALK1	29..98	CDD:467064	22/88 (25%)
		Mediates specificity for BMP ligand	73..76		1/9 (11%)
		TGF_beta_GS	174..200	CDD:462503	2/25 (8%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	100/311 (32%)