Protein Alignment wit and ACVR2B

DIOPT Version :9

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_005265640.1
• Gene: ACVR2B / 93
• HGNCID: 174
• Length: 533
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 169/557 - (30%)
• Similarity: 269/557 - (48%)
• Gaps: 105/557 - (18%)

  Fly    42 GDQDSSGELQEQQVESTPIP-----SEPHRRTC-----------------------PDGYTFCFT 78
            ||..:.|:         |:|     .|...|.|                       .|....|:.
Human    27 GDTRAGGQ---------PLPKGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCYA 82

  Fly    79 IWNQTANGARVVKQGCWKDNTDRTSIC-SQSECTSSAPTSKTSSLYYCCCSGGVCNAQYS----- 137
            .|..::....:||:|||.|:.:    | .:.||.:   |.:...:|:|||.|..||.:::
Human    83 SWRNSSGTIELVKKGCWLDDFN----CYDRQECVA---TEENPQVYFCCCEGNFCNERFTHLPEA 140

  Fly   138 -----VVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAK 197
                 ..||.|                |.....:.||.::|.: |||:.:.:..|...::.:...
Human   141 GGPEVTYEPPP----------------TAPTLLTVLAYSLLPI-GGLSLIVLLAFWMYRHRKPPY 188

  Fly   198 EKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYV 262
            ...:..|.|    ||...|.|..:..:.|:.:...|::|.|.|..|.:..|||||:|.:..|.:.
Human   189 GHVDIHEDP----GPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQ 249

  Fly   263 NERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLR 327
            :||.|::.|.|:...||.:...::|.: :..:|..|:.:....|.|.|:|..|.:|::|.|.:..
Human   250 SEREIFSTPGMKHENLLQFIAAEKRGS-NLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAE 313

  Fly   328 SITRGISHLHTELR--LGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEV 390
            :::||:|:||.::.  .|:.|||.:||||..::|||:::||:..:||||.|::.         |.
Human   314 TMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRF---------EP 369

  Fly   391 AMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQAT 454
            ......:..:|||.||||||:||||:|. ||   :..::|:||:||||||:.:||.....|   .
Human   370 GKPPGDTHGQVGTRRYMAPEVLEGAINFQRD---AFLRIDMYAMGLVLWELVSRCKAADGP---V 428

  Fly   455 PPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW--GGGAAAKVVRDTCEDCWDHDADARLT 517
            ..|..|:|:|:|.|||.:::|.:||..|.||.....|  ..|.|...|  |.|:||||||:|||:
Human   429 DEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCV--TIEECWDHDAEARLS 491

  Fly   518 SLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPT 554
            :.|.|||   :|.:|.......|..|:   :||.|.|
Human   492 AGCVEER---VSLIRRSVNGTTSDCLV---SLVTSVT 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	23/104 (22%)
		STYKc	226..517	CDD:214568	111/295 (38%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	115/304 (38%)
ACVR2B	XP_005265640.1	Activin_recp	48..138	CDD:279413	22/96 (23%)
		STKc_ACVR2b	215..505	CDD:271042	117/310 (38%)
		S_TKc	219..492	CDD:214567	111/290 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820