DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and ACVR2A

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001265508.1	Gene:	ACVR2A / 92	HGNCID:	173	Length:	513	Species:	Homo sapiens

Alignment Length:	493	Identity:	165/493 - (33%)
Similarity:	261/493 - (52%)	Gaps:	67/493 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 CFTIWNQTANGARVVKQGCWKDNT---DRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYS 137
            ||..|...:....:||||||.|:.   |||....:.:         :..:|:|||.|.:||.::|
Human    60 CFATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKD---------SPEVYFCCCEGNMCNEKFS 115

  Fly   138 ------VVEPAPLELGSNEGRTSITNRATEK-QHQSFLASTMLGLAGGLTALTIGIFL-AVQYCR 194
                  |.:|.             :|..|.| .:.:.|..:::.|     .|..||.: |....|
Human   116 YFPEMEVTQPT-------------SNPVTPKPPYYNILLYSLVPL-----MLIAGIVICAFWVYR 162

  Fly   195 TAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQ 259
            ..|....|...|....||...|.|..:..:.|:.:...|::|.|.|..|.::.|||||:|.:..|
Human   163 HHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQ 227

  Fly   260 YYVNERNIYALPLMECPALLSYFGYDERCT-MDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECC 323
            .:.||..:|:||.|:...:|.:.|.::|.| :|  ::..|:.:....|.|.|:|.||.::::|.|
Human   228 SWQNEYEVYSLPGMKHENILQFIGAEKRGTSVD--VDLWLITAFHEKGSLSDFLKANVVSWNELC 290

  Fly   324 GMLRSITRGISHLHTEL-RLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYK 387
            .:..::.||:::||.:: .|.|.|||.::||||.::|||::.:|:.||||||.|||.
Human   291 HIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKF-------- 347

  Fly   388 GEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQMDVYALGLVLWEVATRCSDFYAPG 451
             |...:...:..:|||.||||||:||||:|. ||   :..::|:||:||||||:|:||:....|
Human   348 -EAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRD---AFLRIDMYAMGLVLWELASRCTAADGP- 407

  Fly   452 QATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARL 516
              ...|..|:|:|:|.|||.:.||.:||..|.||:....|...|...::.:|.|:||||||:|||
Human   408 --VDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARL 470

  Fly   517 TSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPT 554
            ::.|..||:.:|..|         :.::.|.::|...|
Human   471 SAGCVGERITQMQRL---------TNIITTEDIVTVVT 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	18/59 (31%)
		STYKc	226..517	CDD:214568	116/293 (40%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	119/302 (39%)
ACVR2A	NP_001265508.1	Activin_recp	38..114	CDD:395845	20/62 (32%)
ACVR2A	NP_001265508.1	STKc_ACVR2a	196..485	CDD:271043	120/305 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820