Protein Alignment wit and ACVR1B

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_064733.3
• Gene: ACVR1B / 91
• HGNCID: 172
• Length: 546
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 130/489 - (26%)
• Similarity: 204/489 - (41%)
• Gaps: 113/489 - (23%)

  Fly   123 YYC----------CCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLAST-MLGLA 176
            :||          ||....||.         ::|....|...      |.:|.|..... ::|:.
Human    82 FYCLSSEDLRNTHCCYTDYCNR---------IDLRVPSGHLK------EPEHPSMWGPVELVGII 131

  Fly   177 GG----LTALTIGIFLAVQY-----------------CRTAKEKPEPEES---PLAPSGPGYSSN 217
            .|    |..:.|.:||.:.|                 |.....|.:..:.   .|:.||.|....
Human   132 AGPVFLLFLIIIIVFLVINYHQRVYHNRQRLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLP 196

  Fly   218 L---RNV-DNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPAL 278
            |   |.| ..:.|..::|.|::|.|.:|.....:|||||:.....:.:..|..||...::....:
Human   197 LFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENI 261

  Fly   279 LSYFGYDER--CTM-----------------DGRMEYQ---------------------LVLSLA 303
            |.:...|.:  |:.                 ..|::|:                     ||....
Human   262 LGFIAADNKADCSFLTLPWEVVMVSAAPKLRSLRLQYKGGRGRARFLFPLNNGTWTQLWLVSDYH 326

  Fly   304 PLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSC 368
            ..|.|.|:|...|:|......:..|...|::|||.|: :|.|.||.:||||:.::|:||:.:..|
Human   327 EHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEI-VGTQGKPGIAHRDLKSKNILVKKNGMC 390

  Fly   369 CIADFGFALKVFGSKYEYKGEVAMAETKSI---NEVGTLRYMAPELLEGAVNLRDCETSLKQMDV 430
            .|||.|.|::          ..|:.:|..|   ..|||.||||||:|:..:|::..: |.|..|:
Human   391 AIADLGLAVR----------HDAVTDTIDIAPNQRVGTKRYMAPEVLDETINMKHFD-SFKCADI 444

  Fly   431 YALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGA 495
            ||||||.||:|.||:.    |.....|:.||...|.|.||.::|:.:|...|.||..|..|....
Human   445 YALGLVYWEIARRCNS----GGVHEEYQLPYYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYE 505

  Fly   496 AAKVVRDTCEDCWDHDADARLTSLCAEERMQEMS 529
            |.:|:.....:||..:..||||:|..::.:.::|
Human   506 ALRVMGKMMRECWYANGAARLTALRIKKTLSQLS 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	6/24 (25%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	101/342 (30%)
ACVR1B	NP_064733.3	TFP_LU_ECD_ALK4	30..102	CDD:467066	4/19 (21%)
		GS	177..207	CDD:197743	7/29 (24%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..539	CDD:271045	101/343 (29%)