Protein Alignment wit and ACVR1

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 132/485 - (27%)
• Similarity: 206/485 - (42%)
• Gaps: 106/485 - (21%)

  Fly    85 NGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVVEPAPLELGSN 149
            :|..|.::||::       :..|.:.|...|.|...::.  ||.|..||...:...|.
Human    61 DGFHVYQKGCFQ-------VYEQGKMTCKTPPSPGQAVE--CCQGDWCNRNITAQLPT------- 109

  Fly   150 EGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYC----------RTAKEKPEPE- 203
                         :.:||..:....|..||..|::...:.:..|          |..:|:..|.
Human   110 -------------KGKSFPGTQNFHLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRD 161

  Fly   204 ---------------ESPLA-------PSGPGYSSNL-----RNV-DNMNLIGMLGSGKYGTVMK 240
                           :|.||       .||.|  |.|     |.| ..:.|:..:|.|:||.|.:
Human   162 VEYGTIEGLITTNVGDSTLADLLDHSCTSGSG--SGLPFLVQRTVARQITLLECVGKGRYGEVWR 224

  Fly   241 GLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGR---MEYQLVLSL 302
            |....:.|||||:.....:.:..|..:|...::....:|.:...|    |..|   .:..|:...
Human   225 GSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASD----MTSRHSSTQLWLITHY 285

  Fly   303 APLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLS 367
            ..:|.|.|:|...||....|..::.||..|::|||.|: .|.|.||.:||||:.::|:||:.:..
Human   286 HEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI-FGTQGKPAIAHRDLKSKNILVKKNGQ 349

  Fly   368 CCIADFGFALKVFGSKYEYKGEVAMAETKSINE--------VGTLRYMAPELLEGAVNLRDCETS 424
            |||||.|               :|:..::|.|:        |||.||||||:|:..:.: ||..|
Human   350 CCIADLG---------------LAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQV-DCFDS 398

  Fly   425 LKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPT 489
            .|::|::|.||||||||.|    .........||.|:...|.:.|||:.|:.:|...:.||..|.
Human   399 YKRVDIWAFGLVLWEVARR----MVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPN 459

  Fly   490 GWGGGAAAKVVRDTCEDCWDHDADARLTSL 519
            .|........:....::||..:..||||:|
Human   460 RWFSDPTLTSLAKLMKECWYQNPSARLTAL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	13/52 (25%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	97/303 (32%)
ACVR1	NP_001096.1	TFP_LU_ECD_ALK2	33..103	CDD:467065	13/50 (26%)
		TGF_beta_GS	179..206	CDD:462503	9/28 (32%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	100/313 (32%)