DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wit and Tgfbr2

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_008764912.1	Gene:	Tgfbr2 / 81810	RGDID:	69651	Length:	592	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	146/539 - (27%)
Similarity:	240/539 - (44%)	Gaps:	111/539 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSECT--------SSAPT-------SK 118
            |......|..:|.:.            ..|....::|...:.|        :::||       ..
  Rat   102 CEKPQEVCVAVWRKN------------DKNITLETVCHDPKFTYHGFTLEDATSPTCVMKEKKRA 154

  Fly   119 TSSLYYCCCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAG------ 177
            ..:.:.|.|:...|| .|.:.        :.|..||..:          |...::.:.|
  Rat   155 GETFFMCSCNTEECN-DYIIF--------NEEYTTSSPD----------LLLVIIQVTGVSLLPP 200

  Fly   178 -GLTALTIGIFLAVQYCRTAKEKPEPEESP--------------LAPSGPGYSSNLRNVDNMN-- 225
             |:....|.||...:..|..|..|..|.|.              |.......||...|..|.|
  Rat   201 LGIAIAVIAIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTE 265

  Fly   226 -----LIGMLGSGKYGTVMKGLLHD------QEVAVKIYPEEHHQYYVNERNIYALPLMECPALL 279
                 |..::|.|::..|.|..|..      :.|||||:|.|.:..:..|::|::...::...:|
  Rat   266 LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENIL 330

  Fly   280 SYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGD 344
            .:...:||.|..|: :|.|:.:....|.||::|..:.:::.:...:..|:.|||:|||::
  Rat   331 QFLTAEERKTEMGK-QYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD----- 389

  Fly   345 QHKPC------VAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGT 403
             |.||      :.|||:.:.|:||:.||:||:.|||.:|::       ...:::.:..:..:|||
  Rat   390 -HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL-------DPTLSVDDLANSGQVGT 446

  Fly   404 LRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSH 468
            .||||||:||..:||.:.| |.||.|||::.|||||:.:||:   |.|: ...|:.|:..:|..|
  Rat   447 ARYMAPEVLESRMNLENME-SFKQTDVYSMALVLWEMTSRCN---AVGE-VKDYEPPFGSKVREH 506

  Fly   469 PSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEM---ST 530
            |..:.|:..|:|.:.||..|:.|......::|.:|..:|||||.:||||:.|..||..|:   ..
  Rat   507 PCVESMKDNVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPDR 571

  Fly   531 LRPRAQAQ---PSSPLLNT 546
            |..|:.:|   |....|||
  Rat   572 LSGRSCSQEKIPEDGSLNT 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	10/78 (13%)
		STYKc	226..517	CDD:214568	100/302 (33%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	104/311 (33%)
Tgfbr2	XP_008764912.1	ecTbetaR2	74..177	CDD:286061	13/95 (14%)
		STYKc	269..566	CDD:214568	105/315 (33%)
		STKc_TGFbR2_like	273..567	CDD:270957	105/312 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810