Protein Alignment wit and Bmpr1a

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_110476.1
• Gene: Bmpr1a / 81507
• RGDID: 70989
• Length: 532
• Species: Rattus norvegicus
• Alignment Length: 544
• Identity: 140/544 - (25%)
• Similarity: 227/544 - (41%)
• Gaps: 89/544 - (16%)

  Fly    31 QEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRT-----CPD----------GYTFCFTIW 80
            |..|:..|......|...:..|..|...|..:.|..:.     |||          |:  ||.|.
  Rat    24 QNLDSMLHGTGMKSDVDQKKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGH--CFAII 86

  Fly    81 NQTANGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVVEPAPLE 145
            .:...|...:..||.|...      |..:|..|.......::.  ||...:|| ||......|:.
  Rat    87 EEDDQGETTLTSGCMKYEG------SDFQCKDSPKAQLRRTIE--CCRTNLCN-QYLQPTLPPVV 142

  Fly   146 LGS-NEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTI--GIFLAVQYCRTAK---------E 198
            :|. .:|..            .:|| .::.:|..:.|:.:  ..|....||::..         |
  Rat   143 IGPFFDGSV------------RWLA-VLISMAVCIVAMIVFSSCFCYKHYCKSISSRGRYNRDLE 194

  Fly   199 KPEP------------EESPLAPSGPGYSSNLRN--VDNMNLIGMLGSGKYGTVMKGLLHDQEVA 249
            :.|.            ::|..:.||.|....::.  ...:.::..:|.|:||.|..|....::||
  Rat   195 QDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVA 259

  Fly   250 VKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIA 314
            ||::.......:..|..||...||....:|.:...|.:.|......| |:......|.|.|:|..
  Rat   260 VKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLY-LITDYHENGSLYDFLKC 323

  Fly   315 NTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKV 379
            .||.......:..|...|:.|||||: .|.|.||.:||||:.::|:|::.:.||||||.|.|:|
  Rat   324 ATLDTRALLKLAYSAACGLCHLHTEI-YGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVK- 386

  Fly   380 FGSKYEYKGEVAMAETKSIN-----EVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWE 439
            |.|           :|..::     .|||.||||||:|:.:::....:..: ..|:|:.||::||
  Rat   387 FNS-----------DTNEVDIPLNTRVGTRRYMAPEVLDESLSKNHFQPYI-MADIYSFGLIIWE 439

  Fly   440 VATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTC 504
            :|.||    ..|.....|:.||...|.|.||::.|:.:|...:.||:....|......:.|....
  Rat   440 MARRC----ITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLM 500

  Fly   505 EDCWDHDADARLTSLCAEERMQEM 528
            .:||.|:..:|||:|..::.:.:|
  Rat   501 SECWAHNPASRLTALRIKKTLAKM 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	28/121 (23%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	95/304 (31%)
Bmpr1a	NP_110476.1	TFP_LU_ECD_BMPR1A	57..140	CDD:467132	21/93 (23%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000250	107..109		0/1 (0%)
		TGF_beta_GS	205..232	CDD:462503	4/26 (15%)
		STKc_BMPR1a	238..524	CDD:271122	95/304 (31%)