Protein Alignment wit and Acvr1

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001418375.1
• Gene: Acvr1 / 79558
• RGDID: 620200
• Length: 528
• Species: Rattus norvegicus
• Alignment Length: 494
• Identity: 137/494 - (27%)
• Similarity: 212/494 - (42%)
• Gaps: 107/494 - (21%)

  Fly    76 CFTIWNQTANGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVVE 140
            ||:..: ..:|.||.::||::       :..|.:.|...|.|...::.  ||.|..||
  Rat    72 CFSSLS-VNDGFRVYQKGCFQ-------VYEQGKMTCKTPPSPGQAVE--CCQGDWCN------- 119

  Fly   141 PAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYC----------RT 195
                        .::|.|...| .:||..|....|..||..|::...:.:..|          |.
  Rat   120 ------------RNVTARLPTK-GKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRR 171

  Fly   196 AKEKPEPE----------------ESPLA-------PSGPGYSSNL-----RNV-DNMNLIGMLG 231
            .:|:..|.                :|.||       .||.|  |.|     |.| ..:.|:..:|
  Rat   172 NQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSG--SGLPFLVQRTVARQITLLECVG 234

  Fly   232 SGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGR--- 293
            .|:||.|.:|....:.|||||:.....:.:..|..:|...::....:|.:...|    |..|
  Rat   235 KGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASD----MTSRHSS 295

  Fly   294 MEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTR 358
            .:..|:.....:|.|.|:|...||....|..::.||..|::|||.|: .|.|.|..:||||:.::
  Rat   296 TQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI-FGTQGKSAIAHRDLKSK 359

  Fly   359 NVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINE--------VGTLRYMAPELLEGA 415
            |:||:.:..|||||.|               :|:..::|.|:        |||.||||||:|:..
  Rat   360 NILVKKNGQCCIADLG---------------LAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDET 409

  Fly   416 VNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVR 480
            :.: ||..|.|::|::|.||||||||.|    .........||.|:...|.:.|||:.|:.:|..
  Rat   410 IQV-DCFDSYKRVDIWAFGLVLWEVARR----MVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV 469

  Fly   481 HKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSL 519
            .:.||..|..|........:....::||..:..||||:|
  Rat   470 DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTAL 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	16/61 (26%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	96/303 (32%)
Acvr1	NP_001418375.1	TFP_LU_ECD_ALK2	52..122	CDD:467065	16/78 (21%)
		TGF_beta_GS	198..225	CDD:462503	9/28 (32%)
		STKc_ACVR1_ALK1	221..518	CDD:271044	99/313 (32%)