Protein Alignment wit and tgfbr1b

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001108531.1
• Gene: tgfbr1b / 792928
• ZFINID: ZDB-GENE-091027-1
• Length: 505
• Species: Danio rerio
• Alignment Length: 509
• Identity: 144/509 - (28%)
• Similarity: 223/509 - (43%)
• Gaps: 93/509 - (18%)

  Fly    65 HRRTCP------DGYTFCFTIWNQTANGARVVKQGCW---KDN---TDRTSICSQSECTSSAPTS 117
            ||  ||      ||  .|:.  :.|..|:...:|. |   |..   .||..:|:.|       |.
Zfish    39 HR--CPNHTCTTDG--LCYV--SITRAGSLTTQQS-WCIGKGELVPPDRPFVCAPS-------TK 89

  Fly   118 KTSSLYYCCCSGGVCNAQYSV-VEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTA 181
            ..|.:|..||....||....: ..|.|.:.....|..:             .|:.:.|....|..
Zfish    90 DDSGIYPLCCDTDWCNKDPDIKAFPVPTQKPPALGPVA-------------FAALIAGPVCVLCF 141

  Fly   182 LTIGIFLAVQYCRTAKEKPEPEESP-------------------LAPSGPGYSSNL---RNVDNM 224
            |.:.:|...........:...||.|                   :..||.|....|   |.:...
Zfish   142 LMVTVFYICHSRSVIHHRVPSEEDPSLDHPFITVGTTLKDLIYDMTTSGSGSGLPLLVQRTIART 206

  Fly   225 NLI-GMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERC 288
            .:: ..:|.|::|.|.:|....:||||||:.....:.:..|..||...::....:|.:...|.:
Zfish   207 IILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNK- 270

  Fly   289 TMDGRMEYQ--LVLSLAPLGCLQDWLIANTLTFSECCGMLR---SITRGISHLHTELRLGDQHKP 348
              |.....|  ||......|.|.|:|...|:|..   ||::   |...|::|||.|: :|.|.||
Zfish   271 --DNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE---GMIKLSLSTASGLAHLHMEI-VGTQGKP 329

  Fly   349 CVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSI---NEVGTLRYMAPE 410
            .:||||:.::|:||:.:.:|||||.|.|::          ..:..:|..|   :.|||.||||||
Zfish   330 AIAHRDLKSKNILVKKNGTCCIADLGLAVR----------HDSATDTIDIAPNHRVGTKRYMAPE 384

  Fly   411 LLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQ 475
            :|:.::|::..| |.|:.|:||:|||.||:|:|||    .|.....|:.||...|.|.||.::|:
Zfish   385 VLDDSINMKHFE-SFKRADIYAMGLVFWEIASRCS----IGGIHEDYQLPYHDLVQSDPSVEEMR 444

  Fly   476 ALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMS 529
            .:|...|.||..|..|....|.:|:.....:||..:..||||:|..::.:.::|
Zfish   445 RVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLS 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	23/84 (27%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	104/307 (34%)
tgfbr1b	NP_001108531.1	TFP_LU_ECD_ALK5	34..106	CDD:467067	22/80 (28%)
		TGF_beta_GS	178..205	CDD:462503	5/26 (19%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	104/308 (34%)