Protein Alignment wit and TGFBR2

DIOPT Version :9

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001020018.1
• Gene: TGFBR2 / 7048
• HGNCID: 11773
• Length: 592
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 133/511 - (26%)
• Similarity: 230/511 - (45%)
• Gaps: 91/511 - (17%)

  Fly    69 CPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSIC---------------SQSECTSSAPTSK 118
            |......|..:|.:.            .:|....::|               :..:|........
Human   102 CEKPQEVCVAVWRKN------------DENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKP 154

  Fly   119 TSSLYYCCCSGGVCN------AQYSVVEP---------------APLELGSNEGRTSITNRATEK 162
            ..:.:.|.||...||      .:|:...|               .||.:..:   ..|.......
Human   155 GETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAIS---VIIIFYCYRV 216

  Fly   163 QHQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLI 227
            ..|..|:||.      .|..|..:....::|....|....:.|....:...:::.|..::   |.
Human   217 NRQQKLSSTW------ETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIE---LD 272

  Fly   228 GMLGSGKYGTVMKGLLHD------QEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDE 286
            .::|.|::..|.|..|..      :.|||||:|.|.:..:..|::|::...::...:|.:...:|
Human   273 TLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEE 337

  Fly   287 RCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPC-- 349
            |.|..|: :|.|:.:....|.||::|..:.:::.:...:..|:.|||:|||::      |.||
Human   338 RKTELGK-QYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD------HTPCGR 395

  Fly   350 ----VAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPE 410
                :.|||:.:.|:||:.||:||:.|||.:|::       ...:::.:..:..:|||.||||||
Human   396 PKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL-------DPTLSVDDLANSGQVGTARYMAPE 453

  Fly   411 LLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQ 475
            :||..:||.:.| |.||.|||::.|||||:.:||:   |.|: ...|:.|:..:|..||..:.|:
Human   454 VLESRMNLENVE-SFKQTDVYSMALVLWEMTSRCN---AVGE-VKDYEPPFGSKVREHPCVESMK 513

  Fly   476 ALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTL 531
            ..|:|.:.||..|:.|......::|.:|..:|||||.:||||:.|..||..|:..|
Human   514 DNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHL 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	9/78 (12%)
		STYKc	226..517	CDD:214568	100/302 (33%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	104/311 (33%)
TGFBR2	NP_001020018.1	ecTbetaR2	74..177	CDD:401023	11/86 (13%)
		STKc_TGFbR2_like	273..567	CDD:270957	105/312 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810