Protein Alignment wit and TGFBR2

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001394055.1
• Gene: TGFBR2 / 7048
• HGNCID: 11773
• Length: 628
• Species: Homo sapiens
• Alignment Length: 535
• Identity: 143/535 - (26%)
• Similarity: 240/535 - (44%)
• Gaps: 103/535 - (19%)

  Fly    69 CPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSIC---------------SQSECTSSAPTSK 118
            |......|..:|.:.            .:|....::|               :..:|........
Human   102 CEKPQEVCVAVWRKN------------DENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKP 154

  Fly   119 TSSLYYCCCSGGVCNAQ--YSVVEPAPLELGSNE--GRTSITNRATEKQH-------QSFLAST- 171
            ..:.:.|.||...||..  :|........:|||.  .|::..|...|..|       :.:..|.
Human   155 GETFFMCSCSSDECNDNIIFSEGRCKIRHIGSNNRLQRSTCQNTGWESAHVMKTPGFREYNTSNP 219

  Fly   172 ----MLGLAGGLTAL-TIGIFLAV---QYC-------------RTAKEKPEPEESP-----LAPS 210
                ::....|::.| .:|:.::|   .||             .|.|.:...|.|.     |...
Human   220 DLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDD 284

  Fly   211 GPGYSSNLRNVDNMN-------LIGMLGSGKYGTVMKGLLHD------QEVAVKIYPEEHHQYYV 262
            ....||...|..|.|       |..::|.|::..|.|..|..      :.|||||:|.|.:..:.
Human   285 RSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWK 349

  Fly   263 NERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLR 327
            .|::|::...::...:|.:...:||.|..|: :|.|:.:....|.||::|..:.:::.:...:..
Human   350 TEKDIFSDINLKHENILQFLTAEERKTELGK-QYWLITAFHAKGNLQEYLTRHVISWEDLRKLGS 413

  Fly   328 SITRGISHLHTELRLGDQHKPC------VAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEY 386
            |:.|||:|||::      |.||      :.|||:.:.|:||:.||:||:.|||.:|::
Human   414 SLARGIAHLHSD------HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRL------- 465

  Fly   387 KGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPG 451
            ...:::.:..:..:|||.||||||:||..:||.:.| |.||.|||::.|||||:.:||:   |.|
Human   466 DPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVE-SFKQTDVYSMALVLWEMTSRCN---AVG 526

  Fly   452 QATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARL 516
            : ...|:.|:..:|..||..:.|:..|:|.:.||..|:.|......::|.:|..:|||||.:|||
Human   527 E-VKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARL 590

  Fly   517 TSLCAEERMQEMSTL 531
            |:.|..||..|:..|
Human   591 TAQCVAERFSELEHL 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	11/85 (13%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	104/311 (33%)
TGFBR2	NP_001394055.1	ecTbetaR2	74..177	CDD:462632	12/86 (14%)
		STKc_TGFbR2_like	309..603	CDD:270957	105/312 (34%)