DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and BMPR2

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001195.2	Gene:	BMPR2 / 659	HGNCID:	1078	Length:	1038	Species:	Homo sapiens

Alignment Length:	1049	Identity:	291/1049 - (27%)
Similarity:	446/1049 - (42%)	Gaps:	263/1049 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WAIYLLLALISLGRATPVPNRQYSCM---SYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEP 64
            |..:.:| |:|...|:  .|::..|.   .||:|                   ..:..:.|..|.
Human    13 WLPWTIL-LVSTAAAS--QNQERLCAFKDPYQQD-------------------LGIGESRISHEN 55

  Fly    65 HRRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKTSSLYYCCC 127
            ....|..|.| |:.:|.::.....:||||||....|... |...||  |::.|:.:..:..:|||
Human    56 GTILCSKGST-CYGLWEKSKGDINLVKQGCWSHIGDPQE-CHYEECVVTTTPPSIQNGTYRFCCC 118

  Fly   128 SGGVCNAQYSVVEPAPLEL------GSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALT--- 183
            |..:||..::...|.|...      ..|...|.|...|:    .|.||..::.|..|...||
Human   119 STDLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALAS----VSVLAVLIVALCFGYRMLTGDR 179

  Fly   184 -IGIFLAVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQE 247
             .|:. ::.....|..:|.                 .::||:.|:.::|.|:||.|.||.|.::.
Human   180 KQGLH-SMNMMEAAASEPS-----------------LDLDNLKLLELIGRGRYGAVYKGSLDERP 226

  Fly   248 VAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWL 312
            ||||::...:.|.::||:|||.:||||...:..:...|||.|.||||||.||:...|.|.|..:|
Human   227 VAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYL 291

  Fly   313 IANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFAL 377
            ..:|..:...|.:..|:|||:::|||||..||.:||.::|||:|:|||||:.|.:|.|:|||.::
Human   292 SLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSM 356

  Fly   378 KVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVAT 442
            ::.|::....||   .:..:|:||||:||||||:|||||||||||::|||:|:|||||:.||:..
Human   357 RLTGNRLVRPGE---EDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFM 418

  Fly   443 RCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW-GGGAAAKVVRDTCED 506
            ||:|.: ||::.|.|:..::.|||:||:|:.||.||.|.|.||.||..| ....|.:.:::|.||
Human   419 RCTDLF-PGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIED 482

  Fly   507 CWDHDADARLTSLCAEERMQEM-----------STLRPRAQAQPSSPLLNTNNLV---------- 550
            |||.||:||||:.||||||.|:           .|:.|.:.|..:...|:.|..|
Human   483 CWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYS 547

  Fly   551 ASPTAEQGINIIATTTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALEREKNHLSYPQQQLQ---- 611
            :|...|..|:...:.....:..|.|||             .||...|:.:|.::|.:||.|
Human   548 SSSYIEDSIHHTDSIVKNISSEHSMSS-------------TPLTIGEKNRNSINYERQQAQARIP 599

  Fly   612 ---------------------------------PYQGRNPCQERNLAPLTMRTP----------- 632
                                             ||.........|:|.....||
Human   600 SPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTEEDLE 664

  Fly   633 -----PVLVERSKKHSFQTQPQENSLSCLEHDVSVEELIASHQHQQQKNTIVSTG-------GNG 685
                 |..|:::.|.|......|:||........:....:|..:...|..:.:||       .||
Human   665 TNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQDFTQTANG 729

  Fly   686 NSCLGQG--------FPKQQN-----TDQKLRGWHGVRALIHKKLFRKEHAEELCRQLQLGEEKS 737
            .:||...        .|||||     |...|...:..:.  .:..|..:|...| :|::.|..|.
Human   730 QACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKE--PRLKFGSKHKSNL-KQVETGVAKM 791

  Fly   738 NLVTA-------------------------------------------------------LRRPN 747
            |.:.|                                                       :....
Human   792 NTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDT 856

  Fly   748 NLDLNPRLDKPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHINGTTNNNSIQSHG-SELQTL--- 808
            .|::|...|:..|  |...||:.|....::.|.:.........|.||:|:..|:. ||...|
Human   857 RLNINSSPDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEGGRTNSNNNNSNPCSEQDVLAQG 919

  Fly   809 ----------TRPASKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFREVFSGR-GSSERLR 862
                      ::|...:||..|..::.....|.            |:::......|: ||.|:::
Human   920 VPSTAADPGPSKPRRAQRPNSLDLSATNVLDGS------------SIQIGESTQDGKSGSGEKIK 972

  Fly   863 DPSERVKTP 871
               :|||||
Human   973 ---KRVKTP 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	23/77 (30%)
		STYKc	226..517	CDD:214568	140/291 (48%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	147/300 (49%)
BMPR2	NP_001195.2	Activin_recp	52..127	CDD:307282	24/76 (32%)
		STKc_BMPR2_AMHR2	207..504	CDD:270956	147/300 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..626		2/32 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..770		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..972		22/111 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1475
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2190
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0006916
OrthoInspector	1	1.000	-	-		oto88651
orthoMCL	1	0.900	-	-		OOG6_110421
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9498
SonicParanoid	1	1.000	-	-		X5015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860