Protein Alignment wit and BMPR1A

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001393488.1
• Gene: BMPR1A / 657
• HGNCID: 1076
• Length: 557
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 142/557 - (25%)
• Similarity: 230/557 - (41%)
• Gaps: 90/557 - (16%)

  Fly    31 QEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRT-----CPD----------GYTFCFTIW 80
            |..|:..|......||..:..|..|...|..:.|..:.     |||          |:  ||.|.
Human    24 QNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGH--CFAII 86

  Fly    81 NQTANGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVVEP---- 141
            .:...|...:..||.|...      |..:|..|.......::.  ||...:|| ||  ::|
Human    87 EEDDQGETTLASGCMKYEG------SDFQCKDSPKAQLRRTIE--CCRTNLCN-QY--LQPTLPP 140

  Fly   142 ---APLELGSNEGRTSITNRAT-------------EKQHQSFLASTMLGLAGGLTALTIGIFLAV 190
               .|...||......:.:.|.             .|.|   |...::.:.|.|.: ..|:.:.:
Human   141 VVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKGH---LLLRVIHIRGQLES-EGGVPVVL 201

  Fly   191 Q-YCRTAK---------EKPEP------------EESPLAPSGPGYSSNLRN--VDNMNLIGMLG 231
            : ||::..         |:.|.            ::|..:.||.|....::.  ...:.::..:|
Human   202 RHYCKSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVG 266

  Fly   232 SGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEY 296
            .|:||.|..|....::||||::.......:..|..||...||....:|.:...|.:.|......|
Human   267 KGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLY 331

  Fly   297 QLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVL 361
             |:......|.|.|:|...||.......:..|...|:.|||||: .|.|.||.:||||:.::|:|
Human   332 -LITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEI-YGTQGKPAIAHRDLKSKNIL 394

  Fly   362 VQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLK 426
            ::.:.||||||.|.|:|       :..:....:......|||.||||||:|:.::|....:..:
Human   395 IKKNGSCCIADLGLAVK-------FNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYI- 451

  Fly   427 QMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW 491
            ..|:|:.||::||:|.||    ..|.....|:.||...|.|.||::.|:.:|...:.||:....|
Human   452 MADIYSFGLIIWEMARRC----ITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRW 512

  Fly   492 GGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEM 528
            ......:.|.....:||.|:..:|||:|..::.:.:|
Human   513 NSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKM 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	29/121 (24%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	93/299 (31%)
BMPR1A	NP_001393488.1	TFP_LU_ECD_BMPR1A	57..140	CDD:467132	22/95 (23%)
		TGF_beta_GS	230..257	CDD:462503	4/26 (15%)
		STKc_BMPR1a	263..549	CDD:271122	93/299 (31%)