Protein Alignment wit and bmpr2a

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_005165892.1
• Gene: bmpr2a / 562822
• ZFINID: ZDB-GENE-070618-1
• Length: 1013
• Species: Danio rerio
• Alignment Length: 1012
• Identity: 287/1012 - (28%)
• Similarity: 442/1012 - (43%)
• Gaps: 227/1012 - (22%)

  Fly     7 LLLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRTCPD 71
            |:..::.||......:.|..| :|.|......:..|.:   ||.......||....:.||
Zfish    14 LIAMVVLLGPVAAAQSEQREC-AYAEQPQGLAERIGGR---GEGLVFHENSTIRCYQGHR----- 69

  Fly    72 GYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC------TSSAPTSKTSSLYYCCCSGG 130
                ||.:|.:..||..:||||||      |::....||      |:....::..:..:|||:..
Zfish    70 ----CFGLWGKKNNGVVLVKQGCW------TNVGDHQECYDRCVVTNPPSVAQNGTYRFCCCNKD 124

  Fly   131 VCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYCRT 195
            :||..::...|.|       ..|:.....:.:.|:..:....|.....:..|.|.:|...:..|
Zfish   125 MCNLNFTEDFPPP-------SPTTAQPLQSRRLHREEVIVVALATVSMVAVLVILLFFGYRMLR- 181

  Fly   196 AKEKPEPE-----ESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPE 255
            .:.|....     |:.|:|..       .::||:.|..::|.|:||||.:..|.|:.||||::..
Zfish   182 GRGKHSLHTLNILETALSPPS-------LDLDNLTLQELIGRGRYGTVYRASLDDRSVAVKVFIS 239

  Fly   256 EHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFS 320
            .:.|.:.|||.||.| |::...:..:...:||...:||.|:.|:|...|.|.|..:|...|:.:.
Zfish   240 ANRQQFTNERMIYRL-LLDHENIARFLESEERVGTEGRTEFLLLLEFYPHGSLCTYLSGRTVDWL 303

  Fly   321 ECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYE 385
            .||.:..|:|||:::||||::.||.:||.|:|||:|:|||||:.|.||.|:|||.::.:.|.:..
Zfish   304 SCCRLALSVTRGLAYLHTEIQRGDVYKPAVSHRDLNSRNVLVKTDGSCVISDFGLSMILTGKRPP 368

  Fly   386 YKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAP 450
            ..||   .:..:|:||||:||||||:|||||||||||::|||:||||||||.||...||:|.: |
Zfish   369 GHGE---EDNSAISEVGTVRYMAPEVLEGAVNLRDCESALKQVDVYALGLVYWETFMRCADLF-P 429

  Fly   451 GQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW-GGGAAAKVVRDTCEDCWDHDADA 514
            |:..|.::..::.|||:||:.:.|||||.|.|.||.||..| ........:::|.|||||.||:|
Zfish   430 GETVPAFQLAFQAEVGNHPTIEDMQALVSREKERPKFPEAWKENSLTVHSLKETMEDCWDQDAEA 494

  Fly   515 RLTSLCAEERMQEMSTLRPRAQ-AQP----SSPLLNTNNLVASPTAEQGINIIATTTTAAAVHH- 573
            |||:.|||||:.|:..:..|.: |.|    |:.|.|..|..|.....:..:::..::|....|.
Zfish   495 RLTAQCAEERLAELLLIWDREKSASPALNHSTALYNHRNFSAGRQTPKVGSVLEHSSTNTEDHEG 559

  Fly   574 ---QMSSDTT------GLIQPPPNQQIPLAALEREKNHLSYPQQQLQPYQ------GRNPCQE-- 621
               .:.:||:      |...|          .|::||.::|..||.|..|      ...|..|
Zfish   560 ADKPLHNDTSVEQTSAGGTNP----------AEKKKNCINYEWQQAQSRQSGTESSSATPVSESC 614

  Fly   622 ---------RNL-APLTM------RTPPVLVERSKKHSFQTQPQENSLSCLEHDVSVEELIASHQ 670
                     .|| |.||.      :..|..|:|:.:.|......|:|    :......|..|||.
Zfish   615 NATHPPPVATNLCAQLTREDLEIPKLDPSEVQRNMRESSDESLMEHS----QKQFCSPETSASHG 675

  Fly   671 HQQQKNTIVS--TGGNGNSCLGQG----FPKQQN--------------------TDQKLRGWHGV 709
            .......:||  :|..|:|..|..    .|||||                    |...||...|
Zfish   676 PFYPLMKMVSEVSGSQGSSRHGDTPITILPKQQNVPKRPSSLSLHVKPGKTSTSTSSSLRMKFG- 739

  Fly   710 RALIHKKLFRKEHAEELCRQLQLGEEKSNLVTALRRPN-----NLDLNPRLDKPPPDQLRSAEQR 769
                  ||.:..     .:::::|..||::|.|.....     |.|....::|...:   .|.:.
Zfish   740 ------KLGKSN-----LKKVEMGVAKSSVVNATHEARLITVANNDAAAAMNKYATE---PAAES 790

  Fly   770 MGTPAHIVPRSLSSSLIK--------------HINGTTNNNSIQSHG-----------------S 803
            .|:.|:   ..|:..|:.              |.:...||||..::|                 :
Zfish   791 AGSSAN---EDLTFGLLNTSPDEQEPLLRREAHPDNANNNNSNNNNGEGDGDGETEGGGEGGENN 852

  Fly   804 ELQTLTRPASKRR-------PGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFRE----------- 850
            |....|..||...       ||....::.:      ||..|...:.|...:.|:
Zfish   853 ESVGPTGDASSSSTVEPVVLPGPCSASTAI------PPQAQSQTQTHGEALLRQNRVRRPERPNS 911

  Fly   851 ---------VFSGR-------GSSERLRDPSERVKTP 871
                     :..||       ||.::::   :|||||
Zfish   912 LDLSITTLPLLGGRSVGDGTEGSGDKIK---KRVKTP 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	30/118 (25%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	141/300 (47%)
bmpr2a	XP_005165892.1	TFP_LU_ECD_BMPR2	32..134	CDD:467134	30/120 (25%)
		STKc_BMPR2_AMHR2	212..508	CDD:270956	141/300 (47%)