DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and bmpr2b

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001034896.1	Gene:	bmpr2b / 555655	ZFINID:	ZDB-GENE-070618-2	Length:	1071	Species:	Danio rerio

Alignment Length:	1065	Identity:	309/1065 - (29%)
Similarity:	478/1065 - (44%)	Gaps:	288/1065 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRTCPDGY 73
            |.|:|...|.....|:..|..     |..|....:|..:|:....:..:|.:.|:..|
Zfish    19 LLLLSAVAAAQSEERERECAF-----NDQHQQVDEQSVAGDWHITRENNTILCSKSSR------- 71

  Fly    74 TFCFTIWNQTANG-ARVVKQGCWKDNTDRTSICSQSEC------TSSAPTSKTSSLY-YCCCSGG 130
              |:.:|.:|.:| .|:||||||      |.|..|.:|      .::.|:...:..| :||||..
Zfish    72 --CYGLWEKTHDGEIRLVKQGCW------TYIGDQQDCHDDRCVVTTTPSQIQNGTYRFCCCSTN 128

  Fly   131 VCNAQYSVVE---PAPLELGSNEGRTSITNRATEKQHQS---FLASTMLGLAGGL-TALTIGIFL 188
            :||..::  |   |:|         ||..||.....|:.   |:|...:.:...| .||..|..:
Zfish   129 MCNVNFT--ENWVPSP---------TSTANRDQPPIHRDEAIFIALASVSIVAVLIVALFFGYRV 182

  Fly   189 AVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIY 253
            .:..|:......:..|:  |||.|..     ::|::.|:.::|.|:||:|.||.|.::.||||::
Zfish   183 MMGECKQGLHNMDMIEA--APSEPSL-----DLDSLKLLELIGRGRYGSVYKGSLDERPVAVKVF 240

  Fly   254 PEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLT 318
            ...:.|.:||||:||.:||:|...:..:...|||.|.||||||.||:...|.|.|..:|..:||.
Zfish   241 TYANRQNFVNERSIYRVPLLEHENIARFIVGDERMTTDGRMEYLLVMEYYPHGSLCRYLSLHTLD 305

  Fly   319 FSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSK 383
            :..||.:..|:|||:::|||||..||.:||.::|||:|:|||||:.|.:|.|:|||.::|:.|::
Zfish   306 WVSCCRLAHSLTRGLAYLHTELLRGDIYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNR 370

  Fly   384 YEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFY 448
            ....||   .|..:|:||||:||||||:||||||||.||::|||:|:||:||:.||...||:|.:
Zfish   371 LVRPGE---EENAAISEVGTIRYMAPEVLEGAVNLRGCESALKQVDMYAIGLIYWETFMRCTDLF 432

  Fly   449 APGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW-GGGAAAKVVRDTCEDCWDHDA 512
             ||:..|.|:..::.|.|:||||:.||.||.|.|.||.||..| ....|.:.:::|.|||||.||
Zfish   433 -PGETVPEYQMAFQAEAGNHPSFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETMEDCWDQDA 496

  Fly   513 DARLTSLCAEERMQEMSTLRPRAQAQPSSP--------LLNTNNLVASPTA-------------- 555
            :||||:.||||||.|:..:..|  .:|.||        |.|..||..|..|
Zfish   497 EARLTAQCAEERMAELLLIWER--NKPVSPTINPMSTALQNERNLTHSRRAPKMGSYPDYSSSSY 559

  Fly   556 ---EQGI--NI---IATTTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALEREKNHLSYPQQQLQP 612
               .:|:  |:   ::|:.|::.....:|..:.|:          .|..|:.:|.::|.:||.|.
Zfish   560 IEDHEGMVKNLPGDVSTSGTSSVGGVGVSGSSGGV----------AATGEKNRNSINYERQQAQA 614

  Fly   613 YQGRNPCQERN------------LAPLTMRTP----------------PVLVERSKK--HSFQTQ 647
             |.|.|..|.:            |.|.|:.|.                ||.::.:::  .:.:..
Zfish   615 -QARLPSPETSGTSLSTTTTTTGLTPSTIMTTISESGHSEDTGAGGSVPVCLQLTEEDLETTKLD 678

  Fly   648 PQENSLSCLEHDVSVEELIASHQHQQ------------------QKNTIVSTGGNGN---SCLGQ 691
            |:|...:..|   |.:|.:..|..:|                  .|.....|||:|:   :..|.
Zfish   679 PKEVDKNLKE---SSDENLMEHSQKQFSAPDPLSSGSTSLLYPLIKLAAEVTGGSGSGGQTDFGV 740

  Fly   692 G-------------FPKQQN-----TDQKLRGWHGVRALIHKKLFRKEHAEELCRQLQLGEEKSN 738
            |             .|||||     |...|...:..|.....:|...:|...| :|::.|..|.|
Zfish   741 GSSGMSDTPTAMFPLPKQQNLPKRPTSLPLNTKNPGRESSSSRLKFGKHKSNL-KQVETGVAKMN 804

  Fly   739 LVTALRRP-------------------------------------NNLDLNPRLDKPPP---DQL 763
            .|.|: .|                                     |...:.|:.:...|   .||
Zfish   805 TVVAV-EPHLATVTNNGPSVRSGAGVVVVNGYGVGNGASSSDAFGNTNPVGPQGEGGAPLLQSQL 868

  Fly   764 RSAEQRMGTPAHIVPRSLSSSLIKH-------------INGTTNNNSIQSH-------------G 802
            ...:.|:..       :::||..:|             .:|.||:|:..|:             .
Zfish   869 SGEDSRLNI-------NINSSPDEHEPLLRREQPAARDHSGRTNSNNNNSNIHTTATFCALTAAD 926

  Fly   803 SELQTLT---------------RPASKRRPGHLRTNSL-MATTGQ-----GPPTEQQMRRQHSLE 846
            ::::.||               ||...|||.  |.||| ::.:.|     |....|:.:
Zfish   927 AQIEALTCLSGAPDGRDNGVPLRPPKPRRPE--RPNSLDLSASSQDSSLLGEAVSQEGK------ 983

  Fly   847 VFREVFSGRGSSERLRDPSERVKTP 871
                    .||:|:::   :|||||
Zfish   984 --------AGSAEKIK---KRVKTP 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	24/83 (29%)
		STYKc	226..517	CDD:214568	142/291 (49%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	149/300 (50%)
bmpr2b	NP_001034896.1	Activin_recp	58..137	CDD:279413	26/95 (27%)
		STKc_BMPR2_AMHR2	217..512	CDD:270956	149/298 (50%)
		S_TKc	217..503	CDD:214567	143/289 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2119
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0006916
OrthoInspector	1	1.000	-	-		otm25818
orthoMCL	1	0.900	-	-		OOG6_110421
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9498
SonicParanoid	1	1.000	-	-		X5015
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.960