DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and acvr2b

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001006871.1	Gene:	acvr2b / 448641	XenbaseID:	XB-GENE-484248	Length:	510	Species:	Xenopus tropicalis

Alignment Length:	579	Identity:	179/579 - (30%)
Similarity:	281/579 - (48%)	Gaps:	105/579 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLALISLGRA-TPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQ---EQQVESTPIPSEPHRR 67
            ||||....|.. ..|..|:  |:.|              :::.||:   :..|||  ...|..:|
Frog    11 LLLATFRAGSGHDEVETRE--CIYY--------------NANWELEKTNQSGVES--CEGEKDKR 57

  Fly    68 TCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSIC-SQSECTSSAPTSKTSSLYYCCCSGGV 131
                  ..|:..|...:....:||:|||.|:.:    | .:.||.:.   .:...:::|||.|..
Frog    58 ------LHCYASWRNNSGFIELVKKGCWLDDFN----CYDRQECIAK---EENPQVFFCCCEGNY 109

  Fly   132 CNAQYS------VVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAV 190
            ||.:::      ..:|.|      :...|:.|         .|..::|.:||    |::.|.||.
Frog   110 CNKKFTHLPEVETFDPKP------QPPASVLN---------ILIYSLLPIAG----LSMAILLAF 155

  Fly   191 QYCRTAKEKP-----EPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAV 250
            ...|  ..||     :..|.|    ||...|.:..:..:.|:.:...|::|.|.|..|.::.|||
Frog   156 WMYR--HRKPPYGHVDINEDP----GPPPPSPMVGLKPLQLLEIKARGRFGCVWKARLLNEYVAV 214

  Fly   251 KIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIAN 315
            ||:|.:..|.:..|:.|:....|:...||.:...::|.: :..||..|:.:....|.|.|:|..|
Frog   215 KIFPIQDKQSWQCEKEIFNTVGMKHENLLEFIAAEKRGS-NLEMELWLITAFHDKGSLTDYLKGN 278

  Fly   316 TLTFSECCGMLRSITRGISHLHTELR--LGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALK 378
            .:|::|.|.:..::.||:::||.::.  .|:.|||.:||||..::|||::.||:..:||||.|::
Frog   279 LVTWNELCHITETMARGLAYLHEDVPRCKGEGHKPAIAHRDFKSKNVLLRNDLTAILADFGLAVR 343

  Fly   379 VFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQMDVYALGLVLWEVAT 442
            .         |.......:..:|||.||||||:||||:|. ||   |..::|:||:||||||:.:
Frog   344 F---------EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRD---SFLRIDMYAMGLVLWEIVS 396

  Fly   443 RCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW--GGGAAAKVVRDTCE 505
            ||:....|   ...|..|:|:|:|.|||.:.:|.:||..|.||:|...|  ..|.|...|  |.|
Frog   397 RCTAADGP---VDEYMLPFEEEIGQHPSLEDLQEVVVHKKMRPVFKDHWLKHPGLAQLCV--TIE 456

  Fly   506 DCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLN-----TNNLVASPTAEQGI 559
            :||||||:|||::.|.|||   :|.:|.......|..|::     ||  |..|..|..|
Frog   457 ECWDHDAEARLSAGCVEER---ISQIRKSVNGTTSDCLVSIVTSVTN--VDLPPKESSI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	18/76 (24%)
		STYKc	226..517	CDD:214568	111/295 (38%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	115/304 (38%)
acvr2b	NP_001006871.1	Activin_recp	42..114	CDD:366445	22/86 (26%)
acvr2b	NP_001006871.1	STKc_ACVR2b	192..482	CDD:271042	117/310 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10939
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920