Protein Alignment wit and sax

DIOPT Version :9

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001246193.1
• Gene: sax / 35731
• FlyBaseID: FBgn0003317
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 612
• Identity: 163/612 - (26%)
• Similarity: 256/612 - (41%)
• Gaps: 134/612 - (21%)

  Fly     5 IYLLLALISL----GRATPVPNRQYSCMSYQEDDNSFHDDDGDQD------SSGELQEQQVESTP 59
            |||:..|..|    .||              |..:...:|..|.|      ||..|..:::.:.|
  Fly     5 IYLVFLLTFLLYNNARA--------------EISDHLREDIPDLDMELSSASSAHLNGKELPAVP 55

  Fly    60 ---IPSEPHRR------------------TCPDGYTFCFTIWN---------QTANGARVVKQGC 94
               :.:.|.|.                  .|.|.|.|..|..|         :.|:|.....:||
  Fly    56 QNSVQTHPRRHIKSKRRMKRRYKCYSCEPPCRDPYEFTHTCQNAIQCWKSRTRDADGQVQESRGC 120

  Fly    95 WKDNTDRTSICSQSECTSSAPTSKTSSLY--YCCCSGGVCNAQYSVVE---PAPLELGSNE---- 150
            .........||||:....:.|:.:.:..:  ..||:|..||      |   |..|...||:
  Fly   121 STSPDQLPMICSQNSLKINGPSKRNTGKFVNVVCCAGDYCN------EGDFPELLPFDSNDVTVI 179

  Fly   151 -GRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYCR---TAKEKPEPE-------- 203
             ..||..::........||...:||      |:|| .|:...:.:   .::.|.:||
  Fly   180 TADTSSISKMLVAVLGPFLVIALLG------AVTI-FFIRRSHRKRLAASRTKQDPEAYLVNDEL 237

  Fly   204 ----------------ESPLAPSGPGYSSNLRN--VDNMNLIGMLGSGKYGTVMKGLLHDQEVAV 250
                            .|..:.||.|....::.  ...:.||..:|.||||.|.:|..|.:.:||
  Fly   238 LRATSAGDSTLREYLQHSVTSGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAV 302

  Fly   251 KIYPEEHHQYYVNERNIYALPLMECPALLSYFGYD----ERCTMDGRMEYQLVLSLAPLGCLQDW 311
            ||:.....:.:..|..||:..|:....:|.:.|.|    ..||     :..|:....|||.|.|.
  Fly   303 KIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCT-----QLWLMTHYYPLGSLFDH 362

  Fly   312 LIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFA 376
            |..|.|:.::...:..||..|:.|||||: .|.|.||.:||||:.::|:||.::.||.|||||.|
  Fly   363 LNRNALSHNDMVWICLSIANGLVHLHTEI-FGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLA 426

  Fly   377 LKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVA 441
            :    :.....|::.:....   :|||.||||||:|:.:::| :|..:|::.|:||.|||||||.
  Fly   427 V----THSHVTGQLDLGNNP---KVGTKRYMAPEVLDESIDL-ECFEALRRTDIYAFGLVLWEVC 483

  Fly   442 TR---CSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDT 503
            .|   |.       ....||.|:...|...|||:.|:.:|.....||..|..|...:....:...
  Fly   484 RRTISCG-------IAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKL 541

  Fly   504 CEDCWDHDADARLTSLCAEERMQEMST 530
            .::||..:.|.||.:|..::.:.::::
  Fly   542 MKECWHQNPDVRLPALRIKKTIHKLAS 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	21/107 (20%)
		STYKc	226..517	CDD:214568	102/297 (34%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	102/306 (33%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	22/96 (23%)
		TM_EGFR-like	182..218	CDD:213052	10/42 (24%)
		TGF_beta_GS	247..274	CDD:285687	4/26 (15%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	104/317 (33%)
		TyrKc	276..553	CDD:197581	101/297 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445034
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940