Protein Alignment wit and acvr1ba

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_005162281.1
• Gene: acvr1ba / 30183
• ZFINID: ZDB-GENE-980526-527
• Length: 519
• Species: Danio rerio
• Alignment Length: 512
• Identity: 139/512 - (27%)
• Similarity: 218/512 - (42%)
• Gaps: 120/512 - (23%)

  Fly   105 CSQSECTSSAPTSKTSSLYYCCCSGGVCNA------------------QYSVVEPA-PLELGSNE 150
            |:.:.|.|:.         |.|.:.|.|.|                  :.|:|.|. |:...|.:
Zfish    34 CNCTACESTG---------YVCETDGACMASTSYINGQEEQQVRICIPRVSLVPPGQPIYCLSAK 89

  Fly   151 G---------------RTSITNRATEKQHQSFLASTMLGLAGG---------LTA---------- 181
            |               ...|.|.::..|.|  ..|.:.|:|.|         |.|
Zfish    90 GLLNTHCCYTDFCNSINLQIPNGSSTGQTQ--YLSNVWGIADGKGGSWGPVELVAVIAGPVFLFC 152

  Fly   182 --LTIGIFLAVQYCRTAKEKPEPE-ESP-------------------LAPSGPGYSSNL---RNV 221
              |.:|:.|...:.|....:...: |.|                   |:.||.|....|   |.|
Zfish   153 LLLIVGVLLFQHHQRNYNHRQRLDVEDPSCDHLYLAKDKTLQDLIFDLSTSGSGSGLPLFVQRTV 217

  Fly   222 -DNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYD 285
             ..:.|..::|.|::|.|.:|.....:|||||:.....:.:..|..||...::....:|.:...|
Zfish   218 ARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFIAAD 282

  Fly   286 ERCTMDGRMEYQ--LVLSLAPLGCLQDWLIANTLTFSECCGMLR---SITRGISHLHTELRLGDQ 345
            .:   |.....|  ||......|.|.|:|...::|..   ||::   |...|::|||.|: ||.|
Zfish   283 NK---DNGTWTQLWLVSDYHEHGSLFDYLNHYSVTIE---GMIKLSLSAASGLAHLHMEI-LGTQ 340

  Fly   346 HKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSI---NEVGTLRYM 407
            .||.:||||:.::|:||:.:.:|.|||.|.|::          ..::.:|..|   ..|||.|||
Zfish   341 GKPGIAHRDLKSKNILVKKNGTCAIADLGLAVR----------HESITDTIDIAPNQRVGTKRYM 395

  Fly   408 APELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFD 472
            |||:|:..:|::..: |.|..|:||||||.||:|.||:    .|.....|:.||...|.|.||.:
Zfish   396 APEVLDETINMKHFD-SFKCADIYALGLVYWEIARRCN----AGGIHEDYQLPYYDLVPSDPSIE 455

  Fly   473 QMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMS 529
            :|:.:|...:.||..|..|....|.:|:.....:||..:..||||:|..::.:.::|
Zfish   456 EMRKVVCDQRLRPNVPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQLS 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	8/50 (16%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	100/307 (33%)
acvr1ba	XP_005162281.1	TFP_LU_ECD_ALK4	31..103	CDD:467066	14/77 (18%)
		TGF_beta_GS	192..219	CDD:462503	7/26 (27%)
		STKc_TGFbR1_ACVR1b_ACVR1c	225..512	CDD:271045	100/308 (32%)